DRSC/TRiP Functional Genomics Resources

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Protein Alignment CDHR2 and cdh-12

DIOPT Version :10

Sequence 1:NP_060145.3 Gene:CDHR2 / 54825 HGNCID:18231 Length:1310 Species:Homo sapiens
Sequence 2:NP_001360600.1 Gene:cdh-12 / 190583 WormBaseID:WBGene00022103 Length:2893 Species:Caenorhabditis elegans


Alignment Length:1396 Identity:300/1396 - (21%)
Similarity:499/1396 - (35%) Gaps:404/1396 - (28%)


- Green bases have known domain annotations that are detailed below.


Human    13 ALVVSVAANV--------APKFLANMTSVILPEDLPVGAQAFWLVAEDQDNDPLTYGMSGPNAYF 69
            |.|..|..|:        ||||..:..|..:|.|.|:|.....:.|.|:|:||:.|...|.....
 Worm  1729 AKVAEVTVNINPTISNAHAPKFTRDHYSGTVPLDAPIGFPIVTMEAFDEDDDPVQYTFKGTGCAD 1793

Human    70 FAVTPKTGEVKLASALDYETLYTFKVTISVSDPYIQVQREMLVIVEDRND---------NAPVFQ 125
            ......:|.|....|:...|..:.:.|:.|||.....:..:.::|::..:         :||.|.
 Worm  1794 QLGIDNSGRVAYKVAMKDRTTGSLECTVVVSDGEHSAETMLTLLVQENEEVETPQKPPNHAPTFS 1858

Human   126 NTAFSTSINETLPVGSV-VFSVLAVDKDMGSAGMVVYSIEKVIPSTGDSEHLFRILANGSIVLNG 189
            ...::.    |:|..|. :.:|:|.|.|   ..::.:|||..     :..:||.:.::|.|.:.|
 Worm  1859 MAEYTF----TIPQNSTDLGTVMATDPD---GDLIDFSIEPT-----EYRNLFHVDSSGRIFVRG 1911

Human   190 SLSYNNKSAFYQLELKACDLGGMYHNTFTIQCSLPVFLSISVV---DQPDLDP--------QFVR 243
            .|....    |...:.|.|.|...         |..|:::.|:   .|..|||        ||.:
 Worm  1912 PLEQQR----YSFLVVAEDRGSPI---------LSSFVNVKVLVEATQEQLDPEASSPQHFQFSQ 1963

Human   244 EFYSASVAEDAAKGTSVLTVEAVDGDKGINDPVIYSISYSTRPG-WFDIGADGVIRVNGSLDREQ 307
            ..||..|......|:.|..|:.|    |:.|    .||||...| :..|.:||.:.|     .:.
 Worm  1964 AVYSWRVESGLPVGSIVGFVKPV----GVTD----GISYSFISGDYLAIDSDGRVAV-----VKP 2015

Human   308 LLEADEEVQLQ------VTATETHLNIYGQEAKVSIWVTVRVMDV------------NDHKPEFY 354
            |.|...:|.:.      :..|...:.:...||...|...|....|            ::..|...
 Worm  2016 LTETVNDVVIAMKNGEILAETRIFVGVEPSEATTRILGPVTTTQVPSTEAPATSTQSSEESPSSR 2080

Human   355 NCSLPACTFTPEEAQVNFTGYVDEHASPRI----------PIDDLTMVVYD----------PDKG 399
            ...||  |..|              |:|||          |.:|::||..:          |.:.
 Worm  2081 TSELP--TLPP--------------ATPRITSRPSQLTLAPTEDISMVSTEQGPTLAPIDLPTRA 2129

Human   400 SNGTFL------LSLGGPDAEAFSVSPERAVGSASVQVLVRVSALVDYERQTAMAVQVVATDSVS 458
            ..|..:      .:...|...|||:..:...|             ::.|.:..:|||   ..|..
 Worm  2130 VTGRVIPLDSGRFTFTSPIYSAFSLEGDFKSG-------------IELEIKPTLAVQ---GSSEP 2178

Human   459 QNFSVAMVTIHLRDINDHRPTFPQSLYVLTVPEHSATGSVVTDSIHATDPDTGAWGQITYSLLPG 523
            .:||:...|:         |.|      || ||    |.::                        
 Worm  2179 PSFSIEDTTL---------PFF------LT-PE----GKLI------------------------ 2199

Human   524 NGADLFQVDPVSGTVTVRNGELLDRESQAVYYLTLQATDGGNLSSSTTLQIHLLDINDNAP---- 584
                :|:.               |||....|..|:.|...|.::.: .|.:.:||:|||.|    
 Worm  2200 ----MFEA---------------DRERHESYLFTIVAKAQGQMARA-RLNVTILDVNDNYPRFQA 2244

Human   585 ---VVSGSYNIFVQEEEGNVSVTIQAHDNDEPGTNNSRLLFNLLPGPYSHNFSLDPDTGLLRNLG 646
               .|..|..:.:    |:....::|.|.|:...|......|   .|:   .|:|...||||..|
 Worm  2245 HPDAVGISRTMHL----GSPIYQLKAVDLDKFPDNQVTYSLN---SPW---ISIDSREGLLRVNG 2299

Human   647 PLDREAIDPALEGRIVLTVLVSDCGEPVLGTKVNVTITVEDINDNLPIFNQSSYNFT--VKEEDP 709
              |.:|...:|:    |||...|.|:|.|.::.::.|.:  ...|:|.|.::....|  ..:..|
 Worm  2300 --DLQAAPESLD----LTVEAQDSGKPPLKSETHLRILI--FKQNIPKFLETPLEVTQIPTKMAP 2356

Human   710 GVLVGVVKAWDADQTEANNRISFSLSGSGANYFMIR---GLVLGAGWAEGYLRLPPDVSLDYETQ 771
            |..:..:.|  .......:.|.:.|..:....|.|:   .|||.        |.|    ||.|..
 Worm  2357 GAHIKTLLA--GPTVSEQDTILYRLVDTVNGLFEIKHAGELVLA--------RRP----LDNEAG 2407

Human   772 PVFNLTVSAENPDPQGGETIV-DVCVNVKDVNDNPPTLDVASLRGI---RVAENGSQHGQVAVVV 832
            ..:.|.|:|||  .:|.:.:| .:.|..:..:.|.|:......:.:   :|.||...|..|..|.
 Worm  2408 REYQLNVTAEN--SKGTDWVVLPIFVEGRLSSTNTPSTSCQFQQKVYRAQVMENSGAHDAVVRVQ 2470

Human   833 A--------SDVDTSAQLEIQLVNILCTKAGVDVGSLCWGWFSVAANGSVYINQSKAIDYEACDL 889
            |        :....|.:.||.                       :.:|.:|  .::.:|.|....
 Worm  2471 AGCQKKFRYAFHTQSKEFEID-----------------------SQSGQIY--TTEPLDRETKST 2510

Human   890 VTLVVRACD----LATDPGFQAYSNNGS-----LLITIEDVNDNAPYF---LPENKTFVIIPE-- 940
            ..|.|...:    ..:|...:..|:..|     :::|:.|.|||||.|   ||::....::.:  
 Worm  2511 YFLTVNVIEQNRKRQSDVQVEQLSSKLSPWQTLVVVTVLDDNDNAPVFLHMLPDSTLAAVVDQNA 2575

Human   941 -LVLPNREVASVRARDDD--SGNNGVILFSILRVDFISKDGATIPFQGVFSIFTSSEADVFAGSI 1002
             |:.|   |..::|||.|  .||                    :.|:     ....|||.|    
 Worm  2576 NLMSP---VTHLQARDLDVLPGN--------------------LKFE-----LEGPEADSF---- 2608

Human  1003 QPVTSLDSTLQGTYQVTVQARDRPSLGPF-LEATTT---------LNLF--TVDQSYRSRLQFST 1055
                .|:|| .|..|: .::.::..:..| |:||.|         ||::  :||.:. .:|..:|
 Worm  2609 ----FLNST-NGLVQL-AKSLEKSDVEHFELQATVTDGKHAVHVPLNIYVLSVDTNV-VQLTKNT 2666

Human  1056 PKEEVGANRQAINAALTQA----TRTTVYIVDIQDIDSAARARPHSYLDAYFVFP----NGSALT 1112
            |..::  :..|:...||:.    ||..|....:.|.......:.|     .||:.    :...::
 Worm  2667 PHSDI--DPSAVERKLTEILGMDTRILVAQPFVSDDGKTDMKKSH-----VFVYSLDNLSQKPIS 2724

Human  1113 LDELSVMIRNDQDSL--TQLLQLGLVVLGSQESQESDLSKQLISVIIGLGVALLLVLVIMTMAFV 1175
            .|||..::....|.|  .|:..:.|:..|:....    .:.|::|:       |||::|..:.|:
 Worm  2725 RDELKRLLMAHSDGLHPLQISSVSLLSTGNAAGN----GQFLLTVV-------LLVVLIALLLFI 2778

Human  1176 CVRKSYNRKLQAMKAAKEARKTAAGVMPSAPAIPGTNMYNTERANPMLNLPNKDLGLEYLSPSND 1240
            |.        ..|..||...:..||||      .|..|.|:..:.|.   |.....:..|:..|.
 Worm  2779 CA--------LIMCCAKRRARNTAGVM------EGAYMINSVGSGPR---PYDVENISRLTAQNV 2826

Human  1241 LDSVSVNSLDDNSVDVDKNSQEIKEHRPPHT 1271
            |....:....::.:|:..|..:|...|...|
 Worm  2827 LAGRPLPDPQEHRIDMSSNDTDIALERDDTT 2857

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CDHR2NP_060145.3 Cadherin_repeat 32..120 CDD:206637 21/96 (22%)
Cadherin_repeat 129..236 CDD:206637 24/110 (22%)
Cadherin_repeat 246..349 CDD:206637 27/121 (22%)
Cadherin_repeat 372..476 CDD:206637 23/129 (18%)
Cadherin_repeat 485..582 CDD:206637 17/96 (18%)
Cadherin_repeat 589..691 CDD:206637 26/101 (26%)
Cadherin_repeat 699..804 CDD:206637 24/110 (22%)
CA <864..926 CDD:214520 14/70 (20%)
Cadherin_repeat 935..1044 CDD:206637 26/125 (21%)
Mediates interaction with USH1C and MYO7B and is required for proper localization to microvilli tips and function in microvilli organization. /evidence=ECO:0000269|PubMed:24725409 1180..1310 20/92 (22%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1259..1310 4/13 (31%)
cdh-12NP_001360600.1 Cadherin_repeat 385..479 CDD:206637
Cadherin_repeat 487..576 CDD:206637
Cadherin_repeat 946..1044 CDD:206637
Cadherin_repeat 1054..1142 CDD:206637
Cadherin_repeat 1152..1247 CDD:206637
Cadherin_repeat 1562..1641 CDD:206637
Cadherin_repeat 1677..1739 CDD:206637 4/9 (44%)
myxo_dep_M36 <1723..1985 CDD:468355 67/280 (24%)
Cadherin_repeat 1861..1943 CDD:206637 23/106 (22%)
Cadherin_repeat <2174..2238 CDD:206637 23/127 (18%)
Cadherin_repeat 2251..2332 CDD:206637 26/96 (27%)
Cadherin_repeat 2347..>2419 CDD:206637 21/87 (24%)
Cadherin_repeat 2451..2554 CDD:206637 22/127 (17%)
Blue background indicates that the domain is not in the aligned region.

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