Protein Alignment TRPM7 and Trpm

DIOPT Version :10

• Sequence 1: NP_060142.3
• Gene: TRPM7 / 54822
• HGNCID: 17994
• Length: 1865
• Species: Homo sapiens
• Sequence 2: NP_001401007.1
• Gene: Trpm / 36694
• FlyBaseID: FBgn0265194
• Length: 2056
• Species: Drosophila melanogaster
• Alignment Length: 1827
• Identity: 627/1827 - (34%)
• Similarity: 910/1827 - (49%)
• Gaps: 386/1827 - (21%)

Human     4 KSWIESTLTKRECVYIIPSSKDPHRCLPGCQICQQLVRCFCGRLVKQHACFTASLAMKYSDVKLG 68
            :||||:...||||:..||..||.             .:|.||:....|.......:....|:
  Fly    39 RSWIETNFQKRECIKFIPCPKDD-------------TKCCCGQAQITHQTIPGIESGSPGDL--- 87

Human    69 DHFNQAIEEWSVEKHTEQSPTDAYGVINFQGGSHSYRAKYVRLSYDTKPEVILQLLLKEWQMELP 133
                     |...|||...||||||.|.||||:|..:|:|||||:||:||:::||..|||.:|||
  Fly    88 ---------WLPTKHTRPQPTDAYGTIEFQGGAHPTKAQYVRLSFDTRPELLVQLFTKEWNLELP 143

Human   134 KLVISVHGGMQKFELHPRIKQLLGKGLIKAAVTTGAWILTGGVNTGVAKHVGDALKEHASRSSRK 198
            ||:|:|.||...|:|..::|:.:.|||:|||.||||||.|||.||||.|.|||||.....:.:.:
  Fly   144 KLLITVQGGKANFDLQAKLKKEIRKGLLKAAKTTGAWIFTGGTNTGVTKQVGDALLLEGQQRTGR 208

Human   199 ICTIGIAPWGVIENRNDLVGRDVVAPYQTLLNPLSKLNVLNNLHSHFILVDDGTVGKYGAEVRLR 263
            :.:|||||||::|..::|:|.:...|..::.:|.|||.||||.|::|:|||:||..|||||:.||
  Fly   209 VVSIGIAPWGIVERNHELLGHNREVPCHSISSPRSKLAVLNNRHAYFLLVDNGTQAKYGAELILR 273

Human   264 RELEKTINQQRIHAR---------IGQGVPVVALIFEGGPNVILTVLEYLQESPPVPVVVCEGTG 319
            |:|||.|:..::|..         .....|||.|:.|||.|.|..||||:.:|||||||||:|:|
  Fly   274 RKLEKFISNLKLHPSKNHWLKTNVTHSSTPVVCLVIEGGTNTIRAVLEYVTDSPPVPVVVCDGSG 338

Human   320 RAADLLAYIHKQTEEGGNLP--DAAEPDIISTIKKTFNFGQNEALHLFQTLMECMKRKELITVFH 382
            |||||||::||...:|...|  ::....:|.||:|||..|.:::..|:|.|::|.:.|.|||||.
  Fly   339 RAADLLAFVHKYASDGEEQPVLESMRDYLIGTIQKTFEVGLDQSEKLYQELLQCTRNKNLITVFR 403

Human   383 I---GSDEHQDIDVAILTALLKGTNASAFDQLILTLAWDRVDIAKNHVFVYGQQWLVGSLEQAML 444
            |   ...|.|::|..|||||.|..:.|..:||.|.|.|:|||||::.:|||||:|..|:|::||:
  Fly   404 IQEKPEGEAQELDQTILTALFKSQHLSPPEQLSLALTWNRVDIARSEIFVYGQEWPNGALDEAMM 468

Human   445 DALVMDRVAFVKLLIENGVSMHKFLTIPRLEELYNTKQGPTNPMLFHLVRDVKQGNLPPGYKITL 509
            .||..||:.|||||:||||||.|||||||||||||||.||.| .|.:::|||:. ::|.||..||
  Fly   469 QALEHDRIDFVKLLLENGVSMKKFLTIPRLEELYNTKHGPAN-TLGYILRDVRP-HIPKGYIYTL 531

Human   510 IDIGLVIEYLMGGTYRCTYTRKRFRLIYNSLGGNNRRSGRNTSSSTPQLRKSHESFGNRADKKEK 574
            .||||||..||||.||..|||::||.||                     .|...|:.|...|...
  Fly   532 HDIGLVINKLMGGAYRSYYTRRKFRPIY---------------------AKVMNSYANACRKSST 575

Human   575 MRHNHFIKTAQPYRPKIDTVMEEGKKKRTKDEIVDIDDPETKRFPYPLNELLIWACLMKRQVMAR 639
            .::       |.|.......:..|....|.         |...|.:|.|||||||.|.|||.||.
  Fly   576 YQY-------QRYAGANSLSLVTGLLPFTS---------EMALFEFPFNELLIWAVLTKRQQMAL 624

Human   640 FLWQHGEESMAKALVACKIYRSMAYEAKQSDLVDDTSEELKQYSNDFGQLAVELLEQSFRQDETM 704
            .:|.||||::||:||:||:|::||:||.:.||..:..|||:.|:.:|.....:||:.|:|||...
  Fly   625 LMWTHGEEALAKSLVSCKLYKAMAHEAAEDDLDTEIYEELRSYAKEFESKGNKLLDFSYRQDAEK 689

Human   705 AMKLLTYELKNWSNSTCLKLAVSSRLRPFVAHTCTQMLLSDMWMGRLNMRKNSWYKVILSILVPP 769
            |.:|||.||.:|||.:||.|||::..|..:||.|:|::|:|:|||.|..|||:.:||||.:.:|.
  Fly   690 AQRLLTCELHSWSNQSCLSLAVAANHRALLAHPCSQVILADLWMGGLRTRKNTNFKVILGLAMPF 754

Human   770 AILLLEYKTKAEMSHIPQSQDAH----QMTMDDS------------------------------- 799
            .|..|::|:|.|:..:||:::.|    .:..|||
  Fly   755 YIRQLDFKSKEELQQMPQTEEEHLENQNLDNDDSDRSQPDAESALLKAKRSISLRYRMGAGANNR 819

Human   800 -----------------ENNFQNITEEIPMEVFKEVRILDSNEGKNEMEIQMKSKKLPITRKFYA 847
                             ||...::|:....:..:...:.:.||.|....:::|       :|||.
  Fly   820 DKALLADTYSVRDTKVHENGKVSLTDSDTAQFREFFNLSEYNEVKQHQPLRLK-------KKFYE 877

Human   848 FYHAPIVKFWFNTLAYLGFLMLYTFVVLVQMEQLPSVQEWIVIAYIFTYAIEKVREIFMSEAGKV 912
            ||.|||.|||.:::||:.||::::|.|||:|||:|..|||..||||.|...||||||..||...:
  Fly   878 FYTAPITKFWADSIAYMFFLIMFSFTVLVKMEQMPRWQEWYSIAYITTLGFEKVREIISSEPVAI 942

Human   913 NQKIKVWFSDYFNISDTIAIISFFIGFGLRFGAKWNFANAYDNHVFVAGRLIYCLNIIFWYVRLL 977
            ..|..||..:.:|..|..|||.|.||...||.     .|..|     .||:|||::.|:||:|:|
  Fly   943 THKFSVWAWNMWNPCDGAAIILFVIGLAFRFR-----ENTMD-----IGRVIYCVDSIYWYLRIL 997

Human   978 DFLAVNQQAGPYVMMIGKMVANMFYIVVIMALVLLSFGVPRKAILYPHEAPSWTLAKDIV----- 1037
            :.|.||:..||.|.|:||||.||.|.||::|:||:||||.|:|||||::.|:|:|.|:::
  Fly   998 NILGVNKYLGPLVTMMGKMVKNMIYFVVLLAVVLMSFGVSRQAILYPNKQPTWSLIKEVIAGSIT 1062

Human  1038 ----------------------------------------------------------------- 1037
                                                                             
  Fly  1063 APGFLGALGHNTRSSYHRGYHTMGAPPVTTTAASTTTGSSSTVPAATTSTTAPIHNEHSNLTSGN 1127

Human  1038 -----FHPYWMIFGEVYAYEID-VCANDSVIPQICGPGTWLTPFLQAVYLFVQYIIMVNLLIAFF 1096
                 |.||:|::|||:|.:|| .|..|...|. |..|.|:||...::||.:..|:::|||||.|
  Fly  1128 LTNVTFQPYFMLYGEVFAGDIDPPCGEDPSQPG-CVTGHWVTPITMSMYLLIANILLINLLIAVF 1191

Human  1097 NNVYLQVKAISNIVWKYQRYHFIMAYHEKPVLPPPLIILSHIVSLFCCICKRRKKD---KTSDGP 1158
            ||::.:|.::|:.||.:||:..:|.|.:|||||||.|.|.|..||. ..|.|:.|.   :..:|.
  Fly  1192 NNIFNEVNSVSHQVWMFQRFTVVMEYQQKPVLPPPFIALCHFYSLL-KYCVRKAKGLEVQRDNGL 1255

Human  1159 KLFLTEEDQKKLHDFEEQCVEMYFNEKDDKFHSGSEERIRVTFERVEQMCIQIKEVGDRVNYIKR 1223
            ||||.::|.::|:||||:|||.:|:|::...:..::||::.|.||||.|..:|:::..:.|....
  Fly  1256 KLFLEKDDLERLYDFEEECVEGFFHEQEIILNQSTDERVKNTTERVETMSQKIEDINQKENIQTA 1320

Human  1224 SLQSLDSQIGHLQD-----LSALTV------------DTLKTLTAQKASEASKVHN--------- 1262
            ::|:::.::..:::     ||.|.|            |.|:..|.....|..::..
  Fly  1321 TVQNIEFRLRKMEESSEQILSHLAVIHRFMSTHTAGADDLRGSTINIPGEMQRMRTISISDTEGG 1385

Human  1263 ------------------------------EITRELSISKHLAQ-----NLIDDG--------PV 1284
                                          ::|.....::.|.:     .:.|:|        |.
  Fly  1386 SGPGGNGGGGGGGGAIVPLGLGAGLNLNSLQVTTRRRFNRSLTEVRPDAYIFDEGTHFEVVPLPE 1450

Human  1285 RP-SVWKKHGVVN----TLSSSLPQGDLE-----SNNPFHCNILMKDDKDPQCNIFGQDLPAVPQ 1339
            .| .|.|....:|    ..:|...:.|.:     |..|..|..:   .:.|...: .||..|..:
  Fly  1451 EPDEVVKSREALNEQVVRKASMQSEADSDIYIPVSQRPSTCETV---KRTPYVTV-RQDTGASTE 1511

Human  1340 RKEFNFP----------EAGSSSGALFP----SAVSPPELRQRLHGVELLKIFNKNQK------- 1383
            .|:...|          ..|.:|....|    .|.....||||     .:.:..:|.:
  Fly  1512 SKDTLTPMGNNDDDQTLVGGDNSDDATPDINFEAARHRALRQR-----TVSLCRRNSETYSLTGA 1571

Human  1384 -LGSSSTSIPHLSSPPTKFFVSTPSQPSCKSHLETGTKDQETVCSKATEGDNTEFGAFVGHRDSM 1447
             :..|..|:..|:|...:....|.|:|.       ..||.......|..|
  Fly  1572 DINRSHISLNQLASLSRRQMSLTQSEPD-------SDKDAPIAQGSAHPG--------------- 1614

Human  1448 DLQRFKETSNKIKILSNNNTSENTLKRV-SSLAGFTD-----CHRTSIPVHSKQAEKIS-RRPST 1505
                        |.:.:...|.|.|.:: |.....||     ||..:.|..|..:.|.| .||.|
  Fly  1615 ------------KSVLHAKPSRNILLKLHSEYTSITDELESVCHMIASPTVSLPSNKASLDRPKT 1667

Human  1506 EDTHEVDSKAALIPDWLQDRPSNREMPSE-----EGTLNGLTSPFKPAMDTNYYYS-AVERNNLM 1564
            | ....::.|.|....|::...|..|..|     .|:::.....|:..:..:|.:. .:.|...:
  Fly  1668 E-MSRAEAAALLEKKHLKECEENDYMILEGLIESRGSIDASAQGFEIGVSIDYSHRYPLRRETAV 1731

Human  1565 RLSQSIP 1571
            .||.|.|
  Fly  1732 ELSPSKP 1738

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
TRPM7	NP_060142.3	LSDAT_euk	106..371	CDD:465665	136/275 (49%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	544..575		4/30 (13%)
		TRPV	<722..1172	CDD:454755	197/580 (34%)
		TRPM_tetra	1194..1249	CDD:465156	17/71 (24%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1386..1407		5/20 (25%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1492..1511		7/19 (37%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1524..1543		4/23 (17%)
		Alpha_kinase_ChaK1_TRMP7	1580..1818	CDD:341221
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1836..1865
Trpm	NP_001401007.1	LSDAT_euk	116..392	CDD:465665	136/275 (49%)
		TRPV	<872..1227	CDD:454755	141/372 (38%)
		TRPM_tetra	1291..1346	CDD:465156	14/54 (26%)