Protein Alignment TRPM4 and Trpm

DIOPT Version :10

• Sequence 1: XP_047294948.1
• Gene: TRPM4 / 54795
• HGNCID: 17993
• Length: 1371
• Species: Homo sapiens
• Sequence 2: NP_001401007.1
• Gene: Trpm / 36694
• FlyBaseID: FBgn0265194
• Length: 2056
• Species: Drosophila melanogaster
• Alignment Length: 1335
• Identity: 344/1335 - (25%)
• Similarity: 575/1335 - (43%)
• Gaps: 295/1335 - (22%)

Human   242 PMCPQFLRLSDRTDPAAVYSLVTRTWGFRAPNLVVSVLGGSGGPVLQTWLQDLLRRGLVRAAQST 306
            |...|::|||..|.|..:..|.|:.|....|.|:::|.||.....||..|:..:|:||::||::|
  Fly   113 PTKAQYVRLSFDTRPELLVQLFTKEWNLELPKLLITVQGGKANFDLQAKLKKEIRKGLLKAAKTT 177

Human   307 GAWIVTGGLHTGIGRHVGVAVRDHQMASTGGTKVVAMGVAPWGVVRNRDTLINPKGSFPARYRWR 371
            ||||.|||.:||:.:.||.|:.......||  :||::|:||||:|.....|:......|..
  Fly   178 GAWIFTGGTNTGVTKQVGDALLLEGQQRTG--RVVSIGIAPWGIVERNHELLGHNREVPCH---- 236

Human   372 GDPEDGVQFP------LDYNYSAFFLVDDGTHGCLGGENRFRLRLESYISQ----------QKTG 420
                 .:..|      |:..::.|.|||:||....|.|...|.:||.:||.          .||.
  Fly   237 -----SISSPRSKLAVLNNRHAYFLLVDNGTQAKYGAELILRRKLEKFISNLKLHPSKNHWLKTN 296

Human   421 VGGTGIDIPVLLLLIDGDEKMLTRI-ENATQA-QLPCLLVAGSGGAADCLA-------------- 469
            |  |....||:.|:|:|....:..: |..|.: .:|.::..|||.|||.||
  Fly   297 V--THSSTPVVCLVIEGGTNTIRAVLEYVTDSPPVPVVVCDGSGRAADLLAFVHKYASDGEEQPV 359

Human   470 -ETLEDTLAPGSGGARQGEARDRIRRFFPKG--DLEVLQAQVERIMTRKELLTVY----SSEDGS 527
             |::.|.|.            ..|::.|..|  ..|.|..::.:....|.|:||:    ..|..:
  Fly   360 LESMRDYLI------------GTIQKTFEVGLDQSEKLYQELLQCTRNKNLITVFRIQEKPEGEA 412

Human   528 EEFETIVLKALVKACGSSEASAYLDELRLAVAWNRVDIAQSELFRGDIQWRSFHLEASLMDALLN 592
            :|.:..:|.||.|    |:..:..::|.||:.|||||||:||:|....:|.:..|:.::|.||.:
  Fly   413 QELDQTILTALFK----SQHLSPPEQLSLALTWNRVDIARSEIFVYGQEWPNGALDEAMMQALEH 473

Human   593 DRPEFVRLLISHGLSLGHFLTPMRLAQLYSA--APSNSLIRNLLDQASHSAGTKAPALKGGAAEL 655
            ||.:||:||:.:|:|:..|||..||.:||:.  .|:|:|...|.|...|..       ||....|
  Fly   474 DRIDFVKLLLENGVSMKKFLTIPRLEELYNTKHGPANTLGYILRDVRPHIP-------KGYIYTL 531

Human   656 RPPDVGHVLRMLLG-----------------KMC-----APRYPSGGAWDPHPGQGFGESMYLLS 698
            .  |:|.|:..|:|                 |:.     |.|..|...:..:.|   ..|:.|::
  Fly   532 H--DIGLVINKLMGGAYRSYYTRRKFRPIYAKVMNSYANACRKSSTYQYQRYAG---ANSLSLVT 591

Human   699 DKATSPLSLDAGLGQAPWSDLLLWALLLNRAQMAMYFWEMGSNAVSSALGACLLLRVMARL---- 759
              ...|.:.:..|.:.|:::||:||:|..|.|||:..|..|..|::.:|.:|.|.:.||..
  Fly   592 --GLLPFTSEMALFEFPFNELLIWAVLTKRQQMALLMWTHGEEALAKSLVSCKLYKAMAHEAAED 654

Human   760 EPDAEEAARRKDLAFKFEGMGVDLFGECYRSSEVRAARLLLRRCPLWGDATCLQLAMQADARAFF 824
            :.|.|.....:..|.:||..|..|....||....:|.|||......|.:.:||.||:.|:.||..
  Fly   655 DLDTEIYEELRSYAKEFESKGNKLLDFSYRQDAEKAQRLLTCELHSWSNQSCLSLAVAANHRALL 719

Human   825 AQDGVQSLLTQKWWGDMAS-TTPIWALVLAFFCPPLIYTRLITFRKSEE---EPTREELEFDMDS 885
            |....|.:|...|.|.:.: ....:.::|....|  .|.|.:.|:..||   .|..||...:..:
  Fly   720 AHPCSQVILADLWMGGLRTRKNTNFKVILGLAMP--FYIRQLDFKSKEELQQMPQTEEEHLENQN 782

Human   886 VINGEGPVGTADPAEKTPLGVPRQSGRPGCCGGRCGGR--------------------------- 923
            :.|.:......| ||...|...|........|.....|
  Fly   783 LDNDDSDRSQPD-AESALLKAKRSISLRYRMGAGANNRDKALLADTYSVRDTKVHENGKVSLTDS 846

Human   924 -----------------------RCLRRWFHFWGAPVTIFMGNVVSYLLFLLLFSRVLLVDFQPA 965
                                   |..::::.|:.||:|.|..:.::|:.||::||..:||..:..
  Fly   847 DTAQFREFFNLSEYNEVKQHQPLRLKKKFYEFYTAPITKFWADSIAYMFFLIMFSFTVLVKMEQM 911

Human   966 PPGSLELLLYFWAFTLLCEELRQGLSGGGGSLASGGPGPGHASLSQRLRLYLADSWNQCDLVALT 1030
            |... |.....:..||..|::|:        :.|..|    .:::.:..::..:.||.||..|:.
  Fly   912 PRWQ-EWYSIAYITTLGFEKVRE--------IISSEP----VAITHKFSVWAWNMWNPCDGAAII 963

Human  1031 CFLLGVGCRLTPGLYHLGRTVLCIDFMVFTVRLLHIFTVNKQLGPKIVIVSKMMKDVFFFLFFLG 1095
            .|::|:..|.......:||.:.|:|.:.:.:|:|:|..|||.|||.:.::.||:|::.:|:..|.
  Fly   964 LFVIGLAFRFRENTMDIGRVIYCVDSIYWYLRILNILGVNKYLGPLVTMMGKMVKNMIYFVVLLA 1028

Human  1096 VWLVAYGVATEGLLRPRDSDFPSILRRVF------------------------------------ 1124
            |.|:::||:.:.:|.|......|:::.|.
  Fly  1029 VVLMSFGVSRQAILYPNKQPTWSLIKEVIAGSITAPGFLGALGHNTRSSYHRGYHTMGAPPVTTT 1093

Human  1125 ---------------------------------------YRPYLQIFGQIPQEDMDVALMEHSNC 1150
                                                   ::||..::|::...|:|      ..|
  Fly  1094 AASTTTGSSSTVPAATTSTTAPIHNEHSNLTSGNLTNVTFQPYFMLYGEVFAGDID------PPC 1152

Human  1151 SSEPGFWAHPPGAQAGTCVSQYANWLVVLLLVIFLLVANILLVNLLIAMFSYTFGKVQGNSDLYW 1215
            ..:|.    .||     ||:  .:|:..:.:.::||:|||||:|||||:|:..|.:|...|...|
  Fly  1153 GEDPS----QPG-----CVT--GHWVTPITMSMYLLIANILLINLLIAVFNNIFNEVNSVSHQVW 1206

Human  1216 KAQRYRLIREFHSRPALAPPFIVISHLRLLLRQLCRRPRSPQPSSPALEHFRVYLSKEAERKLLT 1280
            ..||:.::.|:..:|.|.||||.:.|...||:...|:.:..:....  ...:::|.|:...:|..
  Fly  1207 MFQRFTVVMEYQQKPVLPPPFIALCHFYSLLKYCVRKAKGLEVQRD--NGLKLFLEKDDLERLYD 1269

Human  1281 WES------VHKENFLLARARDKR-ESDSERLKRTSQKV-DLALK---QLGHIREYEQRLKVLER 1334
            :|.      .|::..:|.::.|:| ::.:||::..|||: |:..|   |...::..|.||:.:|.
  Fly  1270 FEEECVEGFFHEQEIILNQSTDERVKNTTERVETMSQKIEDINQKENIQTATVQNIEFRLRKMEE 1334

Human  1335 EVQQCSRVLGWV----------AEALSRSALLPPG 1359
            ..:|....|..:          |:.|..|.:..||
  Fly  1335 SSEQILSHLAVIHRFMSTHTAGADDLRGSTINIPG 1369

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
TRPM4	XP_047294948.1	LSDAT_euk	246..514	CDD:476852	90/302 (30%)
		TRPV	<1008..1240	CDD:454755	72/306 (24%)
Trpm	NP_001401007.1	LSDAT_euk	116..392	CDD:465665	90/300 (30%)
		TRPV	<872..1227	CDD:454755	89/384 (23%)
		TRPM_tetra	1291..1346	CDD:465156	16/54 (30%)