DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment DNAJB12 and DnaJ-1

DIOPT Version :9

Sequence 1:	NP_001352009.1	Gene:	DNAJB12 / 54788	HGNCID:	14891	Length:	377	Species:	Homo sapiens
Sequence 2:	NP_523936.2	Gene:	DnaJ-1 / 38643	FlyBaseID:	FBgn0263106	Length:	334	Species:	Drosophila melanogaster

Alignment Length:	149	Identity:	58/149 - (38%)
Similarity:	72/149 - (48%)	Gaps:	37/149 - (24%)

- Green bases have known domain annotations that are detailed below.

Human   109 KDYYEILGVSRGASDEDLKKAYRRLALKFHPDKNHAPGATEAFKAIGTAYAVLSNPEKRKQYDQF 173
            ||:|:|||:.|.|||:::|||||:||||:|||||.:|.|.|.||.|..||.|||:.:||..:|.:
  Fly     3 KDFYKILGLERKASDDEIKKAYRKLALKYHPDKNKSPQAEERFKEIAEAYEVLSDKKKRDIFDNY 67

Human   174 GDD---KSQAARHGHG---------HGDFHRGFEADISPEDLFNMFFGGGFPSSNVHVYSNGRMR 226
            |:|   ..|....|.|         |||....|.......|.|..||.||
  Fly    68 GEDGLKGGQPGPDGGGQPGAYTYQFHGDPRATFAQFFGSSDPFGAFFTGG--------------- 117

Human   227 YTYQQRQDRRDNQGDGGLG 245
                      ||...||.|
  Fly   118 ----------DNMFSGGQG 126

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
DNAJB12	NP_001352009.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	45..92
		DnaJ	110..>236	CDD:333066	52/137 (38%)
		DUF1977	268..368	CDD:312722
DnaJ-1	NP_523936.2	DnaJ	1..333	CDD:223560	58/149 (39%)
		DnaJ	4..65	CDD:278647	36/60 (60%)
		DnaJ_C	157..320	CDD:199909
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165154093
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0714
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.740