DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment DNAJB12 and DnaJ-H

DIOPT Version :9

Sequence 1:	NP_001352009.1	Gene:	DNAJB12 / 54788	HGNCID:	14891	Length:	377	Species:	Homo sapiens
Sequence 2:	NP_001260431.1	Gene:	DnaJ-H / 34707	FlyBaseID:	FBgn0032474	Length:	440	Species:	Drosophila melanogaster

Alignment Length:	154	Identity:	51/154 - (33%)
Similarity:	71/154 - (46%)	Gaps:	40/154 - (25%)

- Green bases have known domain annotations that are detailed below.

Human   112 YEILGVSRGASDEDLKKAYRRLALKFHPDKNHAPGATEAFKAIGTAYAVLSNPEKRKQYDQFGDD 176
            |::|.|:..|:||::||.||:||.:||||||  |.|.:.||.|..||.|||:||||:.||::|..
  Fly     7 YDVLKVAPDATDEEIKKNYRKLAKEFHPDKN--PDAGDKFKEISFAYEVLSDPEKRRIYDRYGLK 69

Human   177 KSQAARHGHGHGDFHRGFEADISPEDLFNMFFGGGFPSSNV---------------------HVY 220
            ..|....|.          :|.|.      ||...||...|                     .:|
  Fly    70 GLQEGAEGF----------SDASE------FFAQWFPFDRVSSEGRGRRNGKVVVKVELTLEEIY 118

Human   221 SNG-RMRYTYQQRQDRRDNQGDGG 243
            ..| :.:..|.:::......||||
  Fly   119 VGGMKKKVEYNRQKLCSKCNGDGG 142

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
DNAJB12	NP_001352009.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	45..92
		DnaJ	110..>236	CDD:333066	47/145 (32%)
		DUF1977	268..368	CDD:312722
DnaJ-H	NP_001260431.1	DnaJ	1..363	CDD:223560	51/154 (33%)
		DnaJ	5..64	CDD:278647	32/58 (55%)
		DnaJ_C	106..329	CDD:199909	7/37 (19%)
		DnaJ_zf	134..197	CDD:199908	4/9 (44%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910