DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment PPIA and cyp33

DIOPT Version :9

Sequence 1:	NP_066953.1	Gene:	PPIA / 5478	HGNCID:	9253	Length:	165	Species:	Homo sapiens
Sequence 2:	NP_523773.1	Gene:	cyp33 / 36984	FlyBaseID:	FBgn0028382	Length:	300	Species:	Drosophila melanogaster

Alignment Length:	163	Identity:	108/163 - (66%)
Similarity:	123/163 - (75%)	Gaps:	0/163 - (0%)

- Green bases have known domain annotations that are detailed below.

Human     3 NPTVFFDIAVDGEPLGRVSFELFADKVPKTAENFRALSTGEKGFGYKGSCFHRIIPGFMCQGGDF 67
            ||.|||||.:.|...||:...|.||.|||||||||.|.|.|:|:||||..|||:||.||||||||
  Fly   138 NPQVFFDIRIGGNDAGRIVMLLRADVVPKTAENFRQLCTHEQGYGYKGCSFHRVIPEFMCQGGDF 202

Human    68 TRHNGTGGKSIYGEKFEDENFILKHTGPGILSMANAGPNTNGSQFFICTAKTEWLDGKHVVFGKV 132
            |.:||||||||||:||.||||.|||...|.|||||:|.|||||||||||.||:|||.||||||.|
  Fly   203 TNNNGTGGKSIYGKKFNDENFNLKHNSFGTLSMANSGANTNGSQFFICTTKTDWLDNKHVVFGHV 267

Human   133 KEGMNIVEAMERFGSRNGKTSKKITIADCGQLE 165
            ..|..:|..|||.||::|..|:||.|..||:|:
  Fly   268 ISGAEVVRKMERCGSKSGTPSQKIVIYSCGELK 300

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
PPIA	NP_066953.1	cyclophilin_ABH_like	4..162	CDD:238907	104/157 (66%)
cyp33	NP_523773.1	RRM_PPIE	8..80	CDD:240793
cyp33	NP_523773.1	cyclophilin_ABH_like	139..297	CDD:238907	104/157 (66%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0652
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D563773at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.820