Protein Alignment PPAT and Prat

DIOPT Version :10

• Sequence 1: NP_002694.3
• Gene: PPAT / 5471
• HGNCID: 9238
• Length: 517
• Species: Homo sapiens
• Sequence 2: NP_524271.2
• Gene: Prat / 40935
• FlyBaseID: FBgn0004901
• Length: 546
• Species: Drosophila melanogaster
• Alignment Length: 529
• Identity: 315/529 - (59%)
• Similarity: 391/529 - (73%)
• Gaps: 30/529 - (5%)

Human     1 MELEEL-------GIREECGVFGCIASGEWPTQLDVPHVITLGLVGLQHRGQESAGIVTSDGSSV 58
            ||.|.:       |:..||||||.||.|:||||:|:.|||.||||.|||||||||||.||:|...
  Fly    36 MESESISASKELTGLTHECGVFGAIACGDWPTQMDIAHVICLGLVALQHRGQESAGIATSEGKCS 100

Human    59 PTFKSHKGMGLVNHVFTEDNLKKLYVSNLGIGHTRYATTGKCELENCQPFVVETLHGKIAVAHNG 123
            ..|..|||||:::.:|.:|::|||. .|||||||||:|.|...:.|||||.|.|.||.:|:||||
  Fly   101 KNFNVHKGMGMISTLFNDDSMKKLR-GNLGIGHTRYSTAGGSGVVNCQPFEVHTTHGALALAHNG 164

Human   124 ELVNAARLRKKLLRHGIGLSTSSDSEMITQLLAYTPPQEQD-DTPDWVARIKNLMKEAPTAYSLL 187
            ||||...||:::|..|:||||.||||:|.|.|...|....: |.|:|.|||::.|..||.:|||:
  Fly   165 ELVNNESLRREVLARGVGLSTHSDSELIAQSLCCAPEDVSELDGPNWPARIRHFMMLAPLSYSLV 229

Human   188 IMHRDVIYAVRDPYGNRPLCIGRLIPVSDINDKEKKTSETEGWVVSSESCSFLSIGARYYREVLP 252
            ||.:|.||||||.|||||||||:::|::..:.....| ..:|||||||||.||||||||.|||.|
  Fly   230 IMLKDKIYAVRDTYGNRPLCIGKIVPINAGHGNNLDT-PADGWVVSSESCGFLSIGARYVREVEP 293

Human   253 GEIVEISRHNVQTLDIISRSEGNPVAFCIFEYVYFARPDSMFEDQMVYTVRYRCGQQLAIEAPVD 317
            |||||:||...:|:||:.|.:...:||||||||||||.||:||.|||||||.:||:||..||||:
  Fly   294 GEIVELSRSGYRTVDIVERPDFKRMAFCIFEYVYFARGDSIFEGQMVYTVRLQCGRQLWREAPVE 358

Human   318 ADLVSTVPESATPAALAYAGKCGLPYVEVLCKNRYVGRTFIQPNMRLRQLGVAKKFGVLSDNFKG 382
            ||:||:||||.|.||..||.:.|:.:.||||:|||||||||||:.||||||||||||.||:|..|
  Fly   359 ADIVSSVPESGTAAAHGYARESGIEFAEVLCRNRYVGRTFIQPSTRLRQLGVAKKFGALSENVAG 423

Human   383 KRIVLVDDSIVRGNTISPIIKLLKESGAKEVHIRVASPPIKYPCFMGINIPTKEELIANKPEFDH 447
            ||:||:||||||||||.||||||:::||:|||||:||||::|||:|||||||:|||||||...|.
  Fly   424 KRLVLIDDSIVRGNTIGPIIKLLRDAGAREVHIRIASPPLQYPCYMGINIPTREELIANKLNPDQ 488

Human   448 LAEYLGANSVVYLSVEGLVSSVQEGIKFKKQKEKKHDIMIQENGNGLECFEKSGHCTACLTGKY- 511
            ||.::||:|:.||||||||.:||  :|.:...:.|.              :.:|||||||||:|
  Fly   489 LARHVGADSLAYLSVEGLVEAVQ--LKHRDAGDSKS--------------KGTGHCTACLTGEYP 537

Human   512 ---PVELEW 517
               |.||.|
  Fly   538 GGLPDELSW 546

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
PPAT	NP_002694.3	PurF	7..516	CDD:439804	310/513 (60%)
Prat	NP_524271.2	PurF	49..545	CDD:439804	310/513 (60%)