DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment KIF1A and Kif3C

DIOPT Version :9

Sequence 1:	NP_001366560.1	Gene:	KIF1A / 547	HGNCID:	888	Length:	1816	Species:	Homo sapiens
Sequence 2:	NP_651939.4	Gene:	Kif3C / 43820	FlyBaseID:	FBgn0039925	Length:	649	Species:	Drosophila melanogaster

Alignment Length:	781	Identity:	219/781 - (28%)
Similarity:	330/781 - (42%)	Gaps:	219/781 - (28%)

- Green bases have known domain annotations that are detailed below.

Human     5 SVKVAVRVRPFNSREMSRDSKCIIQMSGSTTTIVNPKQPKETPKSFSFDYSYWSHTSPEDINYAS 69
            ::||.||.||.|..|..|:.:.|::::....::.||.......|.|.||..|...|..|
  Fly     4 NIKVVVRCRPMNQTEKERNCQNIVEINEFAVSVTNPSARISQQKKFIFDSVYNMKTDTE------ 62

Human    70 QKQVYRDIGEEMLQHAFEGYNVCIFAYGQTGAGKSYTMMGKQE-KDQQGIIPQLCEDLFSRINDT 133
              .:|.::...:::...||||..||||||||.||::||.|.:. .:..||||:..:.:|.||:.|
  Fly    63 --VIYDEMCYSLVESTIEGYNGTIFAYGQTGCGKTHTMQGDENFSNSTGIIPKCFDHIFERISMT 125

Human   134 TNDNMSYSVEVSYMEIYCERVRDLLNPKNKG----NLRVREHPLLGPYVEDLSKLAVTSYNDIQD 194
            |  |:.|...|:|:|||.||:||||| ||:.    |..::|.|.:|..|..|:...|.:.|...|
  Fly   126 T--NVRYLALVTYLEIYNERIRDLLN-KNENTNVINHFLKELPGIGVSVPTLTTQPVVNANQCYD 187

Human   195 LMDSGNKARTVAATNMNETSSRSHAVFNIIFTQK------RHDAETNITTEKVSKISLVDLAGSE 253
            .:..|||.|..|||.||:.|||||.:|.|...|.      ..||...|..   .|:|||||||||
  Fly   188 WLHFGNKNRVTAATLMNKNSSRSHTIFTITLEQSPFLNSIGSDAFGGICR---GKLSLVDLAGSE 249

Human   254 RADSTGAKGTRLKEGANINKSLTTLGKVISALAEMDSGPNKNKKKKKTDFIPYRDSVLTWLLREN 318
            |...|||:|.||||.:.||.||:.||.|||:|.:           .|...:|:|||.||.||:::
  Fly   250 RQRKTGAQGDRLKEASQINLSLSALGNVISSLVD-----------GKAKHVPFRDSKLTRLLQDS 303

Human   319 LGGNSRTAMVAALSPADINYDETLSTLRYADRAKQIRCNAVINEDPNNKLIRELKDEVTRLRDLL 383
            ||||::|.|::.:||.||:||||:||||||.|||.|.....|||||.:..:|:.::|:..|:.:|
  Fly   304 LGGNTKTLMISCISPTDIHYDETISTLRYASRAKNISNKPKINEDPKDARLRQYQNEILYLKRML 368

Human   384 Y--AQGLGDITDTNTVPGGPKYVSDLENNNLNRGGTVNEAPDPLSTVTNALVGMSPSSSLSALSS 446
            .  .|.:....|.|.:...|..:  :::.|:|            ||....::.:..:...|
  Fly   369 QESQQIINKNNDPNKIIKSPLKI--IQHTNMN------------STKNVQIIDLGRNCKAS---- 415

Human   447 RAASVSSLHERILFAPGSEEAIERLKETEKIIAELNETWEEKLRRTEAIRMEREALLAEMGVAMR 511
                                    .|....|:.:.|
  Fly   416 ------------------------FKTNNSILTKPN----------------------------- 427

Human   512 EDGGTLGVFSPKKTPHLVNLNEDPLMSECLLYYIKDGITRVGREDGERRQDIVLSGHFIKEEHCV 576
                         .|.:.:..|..|.:...:..||..:  :|   |||..|..|     ||:|.
  Fly   428 -------------FPLIQSKEEVQLQARSRIDLIKRSL--IG---GERIHDFEL-----KEKHM- 468

Human   577 FRSDSRGGSEAVVTLEPCEGADTYVNGKKVTEPSILRSGNRIIMGKSHVFRFNHPEQARQERERT 641
                                |..|...:.::..:|..|                         |.
  Fly   469 --------------------ARKYAAQRHLSAIAIALS-------------------------RV 488

Human   642 PCAETPAEPVDWAFAQRELLEKQGIDMKQEMEQRLQELEDQYRREREEATYLLEQQRLDYESKLE 706
            .|.:            |:||:.....:.||:     ::::.|.|:.:|...:||.:..|..|:.
  Fly   489 KCED------------RDLLQGHYATITQEI-----DIKNDYIRKCKEKIKMLEMEVSDLNSEF- 535

Human   707 ALQKQMDSRYYPEVNEEEEEPEDEVQWTERECELALWAFRKW---------KWYQFTSLRDLLWG 762
                |:|          .|:..||::...|:.:.....|.|:         .|...|.|::.||.
  Fly   536 ----QLD----------REDYLDEIRNLGRQVKFHQQLFLKFSSNPGKFDRNWTPDTILQNSLWN 586

Human   763 N 763
            :
  Fly   587 D 587

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
KIF1A	NP_001366560.1	None
Kif3C	NP_651939.4	Motor_domain	3..339	CDD:277568	152/359 (42%)
Kif3C	NP_651939.4	Kinesin	10..339	CDD:278646	149/353 (42%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910