Protein Alignment KIF1A and Khc-73

DIOPT Version :9

• Sequence 1: NP_001366560.1
• Gene: KIF1A / 547
• HGNCID: 888
• Length: 1816
• Species: Homo sapiens
• Sequence 2: NP_001261000.1
• Gene: Khc-73 / 36718
• FlyBaseID: FBgn0019968
• Length: 1957
• Species: Drosophila melanogaster
• Alignment Length: 1992
• Identity: 574/1992 - (28%)
• Similarity: 824/1992 - (41%)
• Gaps: 669/1992 - (33%)

Human     1 MAGASVKVAVRVRPFNSREMSRDSKCIIQMSGSTTTIVNP----KQPKETPKSFSFDYSYWSHTS 61
            ||...:||||||||||.||:..|:|||::|....|.:.||    |..::.||:|:||:.::| .:
  Fly     1 MASDKIKVAVRVRPFNRREIELDTKCIVEMEKQQTILQNPPPLEKIERKQPKTFAFDHCFYS-LN 64

Human    62 PEDINYASQKQVYRDIGEEMLQHAFEGYNVCIFAYGQTGAGKSYTMMGKQEKDQQGIIPQLCEDL 126
            |||.|:|||:.|:..:|..:|.:||:|||.|||||||||:||||||||.||  .:||||:||:.|
  Fly    65 PEDENFASQETVFDCVGRGILDNAFQGYNACIFAYGQTGSGKSYTMMGTQE--SKGIIPRLCDQL 127

Human   127 FSRINDTTNDNMSYSVEVSYMEIYCERVRDLLNPK-NKGNLRVREHPLLGPYVEDLSKLAVTSYN 190
            ||.|.:.:...:.|.|||||||||.|:|.|||:|| ||.:|:||||.::||||:.||:||||||.
  Fly   128 FSAIANKSTPELMYKVEVSYMEIYNEKVHDLLDPKPNKQSLKVREHNVMGPYVDGLSQLAVTSYQ 192

Human   191 DIQDLMDSGNKARTVAATNMNETSSRSHAVFNIIFTQKRHDAETNITTEKVSKISLVDLAGSERA 255
            ||.:||..|||:|||||||||..||||||||:::.||...|..|.::.||||::|||||||||||
  Fly   193 DIDNLMTEGNKSRTVAATNMNAESSRSHAVFSVVLTQILTDQATGVSGEKVSRMSLVDLAGSERA 257

Human   256 DSTGAKGTRLKEGANINKSLTTLGKVISALAEMDSGPNKNKKKKKTDFIPYRDSVLTWLLRENLG 320
            ..|||.|.|||||:||||||||||.|||.||:..:|    ||.....|:|||||||||||::|||
  Fly   258 VKTGAVGDRLKEGSNINKSLTTLGLVISKLADQSNG----KKSGNDKFVPYRDSVLTWLLKDNLG 318

Human   321 GNSRTAMVAALSPADINYDETLSTLRYADRAKQIRCNAVINEDPNNKLIRELKDEVTRLRDLL-Y 384
            |||||.|||.:||:..||:|||||||||||||:|..:||:|||||.::||||:.||..||.:| :
  Fly   319 GNSRTVMVATISPSADNYEETLSTLRYADRAKRIVNHAVVNEDPNARIIRELRHEVETLRSMLKH 383

Human   385 AQG--LGDITDTNTVPGGPKYVSDLENNNLNRGGTVNEAPDPLSTVTNALVGMSPSSSLSALSSR 447
            |.|  :||:.|
  Fly   384 ATGSPVGDVQD------------------------------------------------------ 394

Human   448 AASVSSLHERILFAPGSEEAIERLKETEKIIAELNETWEEKLRRTEAIRMEREALLAEMGVAMRE 512
                                  :|.|:|.::.::::||||||.:||.|:.||:..|.:||::::.
  Fly   395 ----------------------KLAESENLMKQISQTWEEKLVKTERIQNERQQALEKMGISVQA 437

Human   513 DGGTLGVFSPKKTPHLVNLNEDPLMSECLLYYIKDGITRVGREDGERRQDIVLSGHFIKEEHCVF 577
            .    |:...|...:|||||.||.::|.|:||:||.....||....::.||.|||..|:.||||.
  Fly   438 S----GIKVEKNKYYLVNLNADPSLNELLVYYLKDRTLIGGRTISGQQPDIQLSGLGIQPEHCVI 498

Human   578 RSDSRGGSEAVVTLEPCEGADTYVNGKKVTEPSILRSGNRIIMGKSHVFRFNHPEQARQERERTP 642
            ..:..|     :.:||.:||..:|||....|.:.|::|:||:.|..|.||.|.|    :....:.
  Fly   499 TIEDSG-----LYMEPVQGARCFVNGSAAVEKTPLQNGDRILWGNHHFFRVNSP----KSNNTSM 554

Human   643 CA---ETPAEPVDWAFAQRELLEKQGIDMKQEMEQRLQELEDQYRREREEATYLLEQQRLDYESK 704
            ||   :|||:.:|:.||:.|:::.:  .....::..:..||.|:..:::.|   ||:||.:||.:
  Fly   555 CASEPQTPAQLIDYNFARDEIMQNE--LSNDPIQTAIARLERQHEEDKQVA---LEKQRQEYERQ 614

Human   705 LEALQKQMDSRYYPEVNEEEEEPEDEV-----------------QWTERECELALWAFRKWKWYQ 752
            .:.|:..:.    |........|.|.:                 :|.:...|:    ||:
  Fly   615 FQQLRNILS----PSTPYAPYAPYDPLRMGKITPNTPTSQMRVEKWAQERDEM----FRR----- 666

Human   753 FTSL----RDLLWGNAIFLKEANAISVELKKKVQFQFVLLTDTLYSPLPPDLLPPEAAKDRETRP 813
              ||    .|::..|:: ::|||.::.|::||.:|...|       .:||..|.|    :|....
  Fly   667 --SLGQLKTDIMRANSL-VQEANFLAEEMEKKTKFSVTL-------QIPPANLSP----NRRRGA 717

Human   814 F---PRTIVAVEVQDQKNGATHYWTLEKLRQRLDLMREMYDRAAEVPSSVIEDCDNVVTGGDPFY 875
            |   |..:|     .:.|..:..||:|||..:|..|||||.          |..:.|:.|.|
  Fly   718 FVSEPAILV-----KRTNSGSQIWTMEKLENKLIDMREMYQ----------EHKERVLNGLD--- 764

Human   876 DRFPWFRLVGSSAISGCNSYPLLNTCMSERMAALTPSPTFSSPDSDATEPAEEQSVGEEEEEEEE 940
                                                                             
  Fly   765 ----------------------------------------------------------------- 764

Human   941 EEDEEEEDLEDDVFPEHALCDGRDPFYDRPPLFSLVGRAFVYLSNLLYPVPLVHRVAIVSEKGEV 1005
                     ||:..|:       ||||:.....:|:|.|.::|..|.:.|.|.:...|:|::|||
  Fly   765 ---------EDNAKPQ-------DPFYESQENHNLIGVANIFLEVLFHDVKLDYHTPIISQQGEV 813

Human  1006 KGFLRVAVQAISADEEAPDYGSGVRQSGTAKISFDDQHFEKFQSESCPVVGMSRSGTSQEELRIV 1070
            .|.|:|.::.|:.  :.|                        |...|..|..| ||.|::|
  Fly   814 AGRLQVEIERIAG--QMP------------------------QDRMCESVSES-SGDSRDE---- 847

Human  1071 EGQGQGADVGPSADEVNNNTCSAVPPEGLLLDSSEKAALDGPLDAALDHLRLGNTFTFRVTVLQA 1135
                                                  .|.|:|..      .|..|.|||:..|
  Fly   848 --------------------------------------YDDPVDPT------SNQITCRVTIKCA 868

Human  1136 SSISAEYAD-IFCQFNFIHRHDE-------AFSTEPLKNTGRGPPLGFYHVQNIAVEVTKSFIEY 1192
            |.:....:: :|||:.| ..|.|       |.||...:|.    ...|.|.|:..|.:.:.|:|:
  Fly   869 SGLPLSLSNFVFCQYTF-WGHQEMVVPVINAESTAHDQNM----VFKFEHTQDFTVTINEEFLEH 928

Human  1193 IKSQPIVFEVFGHYQQHPFPPLCKDVLSPLRPSRRHFPRVMPLSKPVPATKLSTLTRPCPGPCHC 1257
            .....:..||:||...........:|......:|....|...||:.:.
  Fly   929 CIEGALSIEVWGHRSAGFSKTKGWEVEQQQAKARSLVDRWAELSRKIE----------------- 976

Human  1258 KYDLLVYFEICELEANGDYIPAVVDHRGGMPCMGTFLLHQGIQRRITV----------------- 1305
                 ::.||.||..||:|.|..|.:|..:...|.:.|.||.|||:.|
  Fly   977 -----LWVEIHELNDNGEYSPVEVTNRNEVLTGGIYQLRQGQQRRVNVRVKPVQNSGTLPIICQS 1036

Human  1306 ---------------------------TLLHETGSHIRWKE------------VRELVVGRIRNT 1331
                                       |:|.|     :|.|            ::.|:....:|.
  Fly  1037 IVNVAIGSVTVRSRLQRPLDSYQEEDLTVLRE-----KWSEALGRRRQYLDQQIQMLIKKEEKNE 1096

Human  1332 PETDESL-------------------------------------IDPNI----LSLN-------- 1347
            .|.:..|                                     ::|::    |:||
  Fly  1097 QERERELSLVHQWVSLTEERNAVLVPAPGSGIPGAPASWEPPSGMEPHVPVLFLNLNGDDLSAQN 1161

Human  1348 ------------ILSSGYIHPAQDDRTFYQFE------------AAWDSSMHNSLLLNRVTPYRE 1388
                        |||..:.|      .||..:            |:||||||:|..|||||...|
  Fly  1162 TNDELSVAGINSILSKEHGH------KFYTLQILQHLDKDVCCVASWDSSMHDSQALNRVTEANE 1220

Human  1389 KIYMTLSAYIEMENCTQPAVVTKDFCMVFYSRDA----KLPASRSIRN---LFGSGSLRASESNR 1446
            ::|:.|...:.:.:.....:|.:....:...:..    :|...|.:|.   ::.||......||.
  Fly  1221 RVYLILRTTVRLSHPAPMDLVLRKRLSINIKKGQTLTDRLKKFRLVRGENAIWQSGVTYEVVSNI 1285

Human  1447 VTGVYEL----SLCHVADAGSPGMQRRRRRVLDTSVA--------YVRG----EENLAGWRPRSD 1495
            .....||    ||..:|.:|.           |.|.:        |.||    |..|...|.|.:
  Fly  1286 PKASEELEDRESLAQLAASGD-----------DCSASDGETYIEKYTRGVSAVESILTLDRLRQN 1339

Human  1496 SLILDHQWELE-----KLSLLQEVEKTRHYLLLR-----EKLETAQRP---------------VP 1535
            ..:.    |||     .||:.:.|.......::|     |.|....|.               .|
  Fly  1340 VAVK----ELETAHGQPLSMRKTVSVPNFSQIMRFDASMESLLNVGRSESFADLNNSALGNKFTP 1400

Human  1536 EALSPA------FSEDSESHGSSSASSPLSAEGRPSP---------------------------- 1566
            ...|||      .|..|.....||..||..|.|..||
  Fly  1401 AGHSPAGAGGVIRSRHSFGGKGSSDDSPGKAFGIASPATSKLLGMRMTTLHEEPLGGHRSLDEEP 1465

Human  1567 ----------LEAPNERQRELAVKCLRLLTHTFNREYTHSHVCVSASESKLSEMSVTLLRDPSMS 1621
                      .|...|||:..::.....||.:...:   |.:.|| |.|..|.:|.|...:.:|.
  Fly  1466 EDSYSDSEYAAEYEQERQQNKSMATRSRLTASKTMD---SFMDVS-SHSNQSYLSYTSSANANMK 1526

Human  1622 PL-GVATLTPSSTCPSLVEGRYGATDL-------------------RTP--------QPCSRPAS 1658
            .| |:|||:.||:..|    .||:..:                   .||        .|.:|.|.
  Fly  1527 HLTGLATLSMSSSTSS----GYGSQAVSCNNLSNEDIASMRSMSIDETPDFDRVNSNSPPNRQAR 1587

Human  1659 PEPEL----------LPEADSKKLPS----PARATETDKEPQ 1686
            ..|.|          .||..:|||..    |....|:.:..|
  Fly  1588 VNPFLKDMPKAKIQEQPEQQAKKLQEAFTHPLEQLESSQNAQ 1629

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
KIF1A	NP_001366560.1	None
Khc-73	NP_001261000.1	KISc_KIF1A_KIF1B	4..359	CDD:276816	220/361 (61%)
		KISc	6..359	CDD:214526	220/359 (61%)
		Kinesin_assoc	356..468	CDD:292801	51/191 (27%)
		FHA	446..546	CDD:238017	42/104 (40%)
		KIF1B	741..786	CDD:289208	19/138 (14%)
		DUF3694	<1196..1252	CDD:289256	17/55 (31%)
		CAP_GLY	1786..1850	CDD:279625

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D76316at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100247
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.820