back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment KIF1A and klp2

DIOPT Version :10

Sequence 1:	XP_047300774.1	Gene:	KIF1A / 547	HGNCID:	888	Length:	1825	Species:	Homo sapiens
Sequence 2:	NP_593458.1	Gene:	klp2 / 2543360	PomBaseID:	SPAC664.10	Length:	817	Species:	Schizosaccharomyces pombe

Alignment Length:	367	Identity:	133/367 - (36%)
Similarity:	193/367 - (52%)	Gaps:	57/367 - (15%)

- Green bases have known domain annotations that are detailed below.

Human     5 SVKVAVRVRP-----------FNSREMSRDS-KCIIQMSGSTTTIVNPKQPKETPKSFSFDYSYW 57
            :::|..||||           |..:.....: :.:.|..||:.|....||     .:|:||..:.
pombe   473 NIRVFCRVRPPLGDGESAQIAFPDQNSEASTIEIVAQAPGSSLTGNGIKQ-----YAFNFDRVFS 532

Human    58 SHTSPEDI-NYASQKQVYRDIGEEMLQHAFEGYNVCIFAYGQTGAGKSYTMMGKQEKDQQGIIPQ 121
            ..|:.||: |..||          ::|.|.:|||||||||||||:||::||     ....|:||.
pombe   533 PETTNEDVFNELSQ----------LIQSAMDGYNVCIFAYGQTGSGKTHTM-----SSNTGMIPS 582

Human   122 LCEDLFSRINDTTNDNMSYSVEVSYMEIYCERVRDLL---NPKNKG--NLRVREHPLLG-PYVED 180
            ....:::|..........|.:|..::|||.|.:.|||   |.:.||  .|.:......| ..:.:
pombe   583 SVRMIYNRSTSLKERGWEYRMEGQFLEIYNETIIDLLASGNEEEKGKKKLEIYHDTKAGRTTITN 647

Human   181 LSKLAVTSYNDIQDLMDSGNKARTVAATNMNETSSRSHAVFNIIFTQKRHDAETNITTEKV--SK 243
            ::...:.:...:..|:|..:|.|:|||||.||.|||||:||.:      |...:|.||.:.  |.
pombe   648 ITSEPLDTPEQVTWLLDQASKNRSVAATNANEHSSRSHSVFML------HLNGSNSTTGETCRST 706

Human   244 ISLVDLAGSERADSTGAKGTRLKEGANINKSLTTLGKVISALAEMDSGPNKNKKKKKTDFIPYRD 308
            ::|:|||||||..|:.:.|.||||...|||||:.||.||.||.   ||       |:..:||||:
pombe   707 LNLIDLAGSERLSSSQSVGERLKETQAINKSLSCLGDVIHALG---SG-------KEGTYIPYRN 761

Human   309 SVLTWLLRENLGGNSRTAMVAALSPADINYDETLSTLRYADR 350
            |.||.||:.:|||||:|.|...:||...:..|||.:||:|.:
pombe   762 SKLTNLLQYSLGGNSKTLMFVNISPLKQHVPETLCSLRFATK 803

Known Domains:

Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 592.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.