Protein Alignment KIF1A and klp8

DIOPT Version :10

• Sequence 1: XP_047300774.1
• Gene: KIF1A / 547
• HGNCID: 888
• Length: 1825
• Species: Homo sapiens
• Sequence 2: NP_594675.1
• Gene: klp8 / 2542849
• PomBaseID: SPAC144.14
• Length: 511
• Species: Schizosaccharomyces pombe
• Alignment Length: 543
• Identity: 153/543 - (28%)
• Similarity: 246/543 - (45%)
• Gaps: 143/543 - (26%)

Human     1 MAGASVKVAVRVRPFNSREMSRDSKCIIQMS--GSTTTIVNPKQPKE---------TPKSFSFDY 54
            |:.|:|:|.|||||.:.||:|:.::.::.:.  ..|.||..||...:         .|::|:||.
pombe     1 MSTANVRVIVRVRPKSLRELSKSAEDLLSVDSHNKTVTITPPKHGLKHSRHKNRVNGPRTFAFDE 65

Human    55 SYWSHTSPEDINYASQKQVYRDIGEEMLQHAFEGYNVCIFAYGQTGAGKSYTMMGKQEKDQQGII 119
            .: :.::||..|.:.|:.||...|..:::...||:|.|...|||.|.||:|:::|.  :.|.|||
pombe    66 CF-APSAPESKNLSGQEDVYESTGPLLVKSILEGFNSCFITYGQKGTGKTYSVVGL--RGQPGII 127

Human   120 PQLCEDLFSRIN--DTTNDNMSYSVEVSYMEIYCERVRDLLNPKNKGN------LRVREHPLLGP 176
            |.:.|.:|..|:  ...:.|.:.:|.:|..||..|...|||.|....:      :.|::..|.|.
pombe   128 PHISESIFEEIDKLKKKSPNTTITVSISLAEIIEETPYDLLQPNVNSSHTPGETVFVQKDSLTGY 192

Human   177 YVEDLSKLAVTSYNDIQDLMDSGNKARTVAATNMNETSS------RSHAVFNIIFTQKRHDAETN 235
            ::..||:..|.|..:|...:       .:||.|:....|      :.|:||:::..|:..|.:|.
pombe   193 HLHGLSEFEVGSAQEIDAFL-------RLAAKNIRTELSDISGVRKGHSVFSLVVQQRIIDPKTR 250

Human   236 ITTEKVSKISLVDLA----GSERADSTGAKGTRLKEGANINKSLTTLGKVISALAEMDSGPNKNK 296
            .:.:|.|::.::|||    ||:|.:|..:     .|.::.||||:.|.:||:||.
pombe   251 HSLKKASRLQIIDLASFSKGSQRNESISS-----FESSSNNKSLSVLNRVIAALT---------- 300

Human   297 KKKKTDFIPYRDSVLTWLLRENLGGNSRTAMVAALSPADINYDETLSTLRYADRAKQIRCNAVIN 361
            .||....|||:|||||.||::.||||.||.|:..:||.|  :|:|.|.|||::.|::|:..:.||
pombe   301 SKKNDVLIPYKDSVLTTLLQDALGGNCRTIMLTCVSPCD--FDDTFSALRYSEAARRIKNISNIN 363

Human   362 ----EDPNNKLIRELKDEVTRLRDLLYAQGLGDITDTNTVPGGPKYVSDLENNNLNRGGTVNEAP 422
                ...||:  .||.|.:|.|.                        ||.|  .|.|
pombe   364 CKEAYSTNNE--GELDDILTTLE------------------------SDRE--QLRR-------- 392

Human   423 DPLSTVTNALVGMSPSSSLSALSSRAASVSSLHERILFAPGSEEAIERLKETEKIIAELNETWEE 487
                                            ||            |..::..|.|.|:...:||
pombe   393 --------------------------------HE------------EHSQKLLKFIEEIRNDYEE 413

Human   488 KLRRTEAIRMEREALLAEMGVAM 510
               |..|:..:..||.|.:.:|:
pombe   414 ---RIHALESQNSALKAHLRLAV 433

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
KIF1A	XP_047300774.1	KISc_KIF1A_KIF1B	4..361	CDD:276816	124/385 (32%)
		Kinesin_assoc	358..549	CDD:465047	28/157 (18%)
		FHA_KIF1A	525..639	CDD:438778
		ERM_helical	658..>711	CDD:466641
		KIF1B	839..886	CDD:463574
		DUF3694	1275..1431	CDD:463599
		PH_KIFIA_KIFIB	1706..1808	CDD:269939
klp8	NP_594675.1	KISc	5..354	CDD:276812	121/375 (32%)