Protein Alignment KIF1A and unc-104

DIOPT Version :10

• Sequence 1: XP_047300774.1
• Gene: KIF1A / 547
• HGNCID: 888
• Length: 1825
• Species: Homo sapiens
• Sequence 2: NP_001022041.2
• Gene: unc-104 / 174144
• WormBaseID: WBGene00006831
• Length: 1628
• Species: Caenorhabditis elegans
• Alignment Length: 1856
• Identity: 879/1856 - (47%)
• Similarity: 1154/1856 - (62%)
• Gaps: 298/1856 - (16%)

Human     4 ASVKVAVRVRPFNSREMSRDSKCIIQMSGSTTTIVNPKQPKETPKSFSFDYSYWSHTSPEDINYA 68
            :||||||||||||.||:|..|||::|::|:||||......||. .||:||:||||. :..|.::.
 Worm     2 SSVKVAVRVRPFNQREISNTSKCVLQVNGNTTTINGHSINKEN-FSFNFDHSYWSF-ARNDPHFI 64

Human    69 SQKQVYRDIGEEMLQHAFEGYNVCIFAYGQTGAGKSYTMMGK-QEKDQQGIIPQLCEDLFSRIND 132
            :|||||.::|.|||:|||||||||||||||||:||||||||| .:.|:.||||:||.|||:||::
 Worm    65 TQKQVYEELGVEMLEHAFEGYNVCIFAYGQTGSGKSYTMMGKANDPDEMGIIPRLCNDLFARIDN 129

Human   133 TTNDNMSYSVEVSYMEIYCERVRDLLNPKNKGNLRVREHPLLGPYVEDLSKLAVTSYNDIQDLMD 197
            ..:.::.|||||||||||||||:|||||.:.|||||||||||||||:||:|:||.||:||.:|||
 Worm   130 NNDKDVQYSVEVSYMEIYCERVKDLLNPNSGGNLRVREHPLLGPYVDDLTKMAVCSYHDICNLMD 194

Human   198 SGNKARTVAATNMNETSSRSHAVFNIIFTQKRHDAETNITTEKVSKISLVDLAGSERADSTGAKG 262
            .|||||||||||||.|||||||||.|:.|||||.|::|:.|||.||||||||||||||:||||:|
 Worm   195 EGNKARTVAATNMNSTSSRSHAVFTIVLTQKRHCADSNLDTEKHSKISLVDLAGSERANSTGAEG 259

Human   263 TRLKEGANINKSLTTLGKVISALAEMDSGPNKNKKKKKTDFIPYRDSVLTWLLRENLGGNSRTAM 327
            .||||||||||||||||.|||.|||    .:..|||.....||||||||||||||||||||:|||
 Worm   260 QRLKEGANINKSLTTLGLVISKLAE----ESTKKKKSNKGVIPYRDSVLTWLLRENLGGNSKTAM 320

Human   328 VAALSPADINYDETLSTLRYADRAKQIRCNAVINEDPNNKLIRELKDEVTRLRDLLYAQGLGDIT 392
            :|||||||||:||||||||||||||||.|.||:|||||.||||||.:||.:||.:|..:|: |:|
 Worm   321 LAALSPADINFDETLSTLRYADRAKQIVCQAVVNEDPNAKLIRELNEEVIKLRHILKDKGI-DVT 384

Human   393 DTNTVPG----GPKYVSDLENNNLNRGGTVNEAPDPLSTVTNALVGMSPSSSLSALSSRAASVSS 453
            |....||    |||.                                               .:.
 Worm   385 DVQETPGKHKKGPKL-----------------------------------------------PAH 402

Human   454 LHERILFAPGSEEAIERLKETEKIIAELNETWEEKLRRTEAIRMEREALLAEMGVAMREDGGTLG 518
            :||:          :|:|:|:||::||:.:|||:||..||.||.:||..|.:||:|..|||.|||
 Worm   403 VHEQ----------LEKLQESEKLMAEIGKTWEQKLIHTEEIRKQREEELRDMGLACAEDGTTLG 457

Human   519 VFSPKKTPHLVNLNEDPLMSECLLYYIKDGITRVGREDGERRQDIVLSGHFIKEEHCVFRSDSRG 583
            ||||||.||||||||||||||||:||:|:|:|.|||.:.|.|.||:|||..|.|.||.|.::.
 Worm   458 VFSPKKLPHLVNLNEDPLMSECLIYYLKEGVTSVGRPEAEHRPDILLSGEAILELHCEFINED-- 520

Human   584 GSEAVVTLEPCEGADTYVNGKKVTEPSILRSGNRIIMGKSHVFRFNHPEQARQERERTPCAETPA 648
             ....:|::|  .|..|:|||:||.|::|.:|:|:|:|:.||||:|.|::|||.|..  .|....
 Worm   521 -GNVTLTMKP--NASCYINGKQVTTPTVLHTGSRVILGEHHVFRYNDPQEARQSRHN--LAAIAE 580

Human   649 EPVDWAFAQRELLEKQGIDMKQEMEQRLQELEDQYRREREEATYLLEQQRLDYESKLEALQKQMD 713
            :|:||.:||:|||:|||||:|.:||:::.|:|.|||||:.|....:..|..:|||.:|.||||:|
 Worm   581 QPIDWKYAQQELLDKQGIDLKADMEKKMLEMESQYRREKVELEQKMYHQTREYESMIENLQKQVD 645

Human   714 -SRYY----PEVNEEE--------EEPEDEVQWTERECELALWAFRKWKWYQFTSLRDLLWGNAI 765
             ::.|    ..:.|.|        |.|| |::||..:..:.|.|..||:::||||:||.||||||
 Worm   646 LAQSYISGGGSIWEGERMLTSSLLEFPE-ELKWTSDQKRVVLKAAIKWRYHQFTSVRDDLWGNAI 709

Human   766 FLKEANAISVELKKKVQFQFVLLTDTLYSPLPPDLLPPEAAKDRETRPFPRTIVAVEVQDQKNGA 830
            |:||||||||||||||||||.|||||:|||||||||||  .:|...||:|:|:||::|||.||||
 Worm   710 FVKEANAISVELKKKVQFQFALLTDTMYSPLPPDLLPP--GEDLTLRPYPKTVVAIQVQDLKNGA 772

Human   831 THYWTLEKLRQRLDLMREMYDRAAEVPSSVIEDCDNVVTGGDPFYDRFP-----WFRLVGSSAIS 890
            ||||::|||:|||:.||..|:....|             .|.|....:|     |
 Worm   773 THYWSIEKLKQRLEDMRIFYNSELSV-------------AGTPVDVPYPPVAEGW---------- 814

Human   891 GCNSYPLLNTCMSERMAALTPSPTFSSPDSDATEPAEEQSVGEEEEEEEEEEDEEEEDLEDDVFP 955
                           :|||..:.....||....|...:.          .|.|.|....:.|...
 Worm   815 ---------------LAALNRNSARLIPDRQRLEAMRDM----------YETDAEMSPADGDPMM 854

Human   956 EHALCDGRDPFYDRPPLFSLVGRAFVYLSNLLYPVPLVHRVAIVSEKGEVKGFLRVAVQAISADE 1020
            :..:  |.||||||.|.|.:||||||||:|||:.|||:|:||:|:|||||||:|:||::.:..|
 Worm   855 DALM--GTDPFYDRFPWFRMVGRAFVYLNNLLHNVPLIHKVAVVNEKGEVKGYLKVAIEPVQKD- 916

Human  1021 EAPDYGSGVRQSGTAKISFDDQHFEKFQSESCPVVGMSRSGTSQEELRIVEGQGQGADVGPSADE 1085
            |..:...||||  |||:.|..:.|.|.....
 Worm   917 EVINQKKGVRQ--TAKLHFRKEDFLKSHKNG---------------------------------- 945

Human  1086 VNNNTCSAVPPEGLLLDSSEKAALDGPLDAALDHLRLGNTFTFRVTVLQASSISAEYADIFCQFN 1150
                            ::|:..||..|     :|::....|.|||.||||..::..|:|:|||||
 Worm   946 ----------------ETSDSDALAFP-----EHMQEEVEFCFRVVVLQAIDVADTYSDVFCQFN 989

Human  1151 FIHRHDEAFSTEPLKNTGRGPPLGFYHVQNIAVEVTKSFIEYIKSQPIVFEVFGHYQ----QHPF 1211
            |:|||||||||||:||:  ..||.|.|.||:.::::|:|:.|:...||:||||||:|    |..|
 Worm   990 FLHRHDEAFSTEPMKNS--KSPLTFEHTQNLHIKMSKTFLHYLHHFPIIFEVFGHFQPKSEQFNF 1052

Human  1212 ----PPLCKDVLSPL---RPSRRHFPRVMPLSKPVPATKLSTLTRPCPGPCHCKYDLLVYFEICE 1269
                ..|.:.:.:.|   :||       :.:|.||.:.|.:...:........|:||||:|||||
 Worm  1053 ERQNSALGRRLSTKLTFQQPS-------LVISTPVKSKKANAPIQNNNASVKSKHDLLVWFEICE 1110

Human  1270 LEANGDYIPAVVDHRGGMPCMGTFLLHQGIQRRITVTLLHETGSHIRWKEVRELVVGRIRNTPE- 1333
            |..||:|:|.:|||..|:|..|.|||||||||||.:|:.||.| .::||:.:||||||||..||
 Worm  1111 LANNGEYVPTIVDHAQGLPTHGIFLLHQGIQRRIKITICHEKG-ELKWKDCQELVVGRIRAGPEW 1174

Human  1334 --TDESLIDPNILSLNILSSGYIHPAQDDRQFLDSDIPRTFYQFEAAWDSSMHNSLLLNRVTPYR 1396
              .|    |.::|||.:....::..:.||         |||:|||||||||:|||.|||||:.|.
 Worm  1175 AGGD----DVDVLSLGLFPGTFMEFSMDD---------RTFFQFEAAWDSSLHNSPLLNRVSNYG 1226

Human  1397 EKIYMTLSAYIEMENCTQPAVVTKDFCMVFYSRDAKL-PASRSIRNLFGSGSLRASESNRVTGVY 1460
            ::||||||||:|::.|.||||||||.|::.|:||:|: .|||..|:|.| |..::.|.|||.|||
 Worm  1227 DQIYMTLSAYMELDGCAQPAVVTKDLCLLIYARDSKISAASRFCRSLVG-GISKSPEMNRVPGVY 1290

Human  1461 ELSLCHVADAGSPGMQRRRRRVLDTSVAYVRGEENLAGWRPRSDSLILDHQWELEKLSLLQEVEK 1525
            :|.|   .|....|..||:|||||||.|||||||||..||||.||||.:||||||||:.||:||:
 Worm  1291 QLCL---KDGSDSGAIRRQRRVLDTSSAYVRGEENLGQWRPRGDSLIFEHQWELEKLTRLQQVER 1352

Human  1526 TRHYLLLREKLETAQRPVPEALSPAFSEDSESHGSSSASSPLSAEGRPSPLEAPNERQRELAVKC 1590
            .|.:|.||::|: .::...||.:|.           |...|:.|......|:   |:.:.:..|.
 Worm  1353 VRLFLRLRDRLK-GKKNKGEARTPV-----------SPCDPVCAIPESIKLD---EKDKGIVGKV 1402

Human  1591 LRLLTH--TFNREYTHSHVCVSASESKLSEMSVTLLRDPSMSPLGVATLTPSSTCPSLVEGRYGA 1653
            |.|:..  ..|::        ..:.:|..|:|.....:...||:...:|..||....|:
 Worm  1403 LGLIRRKIPMNKD--------PPTGNKAQELSDESGSNSITSPVSDKSLIKSSRSSDLL------ 1453

Human  1654 TDLRTPQPCSRPASPEPELLPEAD-------SKKLPSPARATETDKEPQRLLVPDIQEIRVSPIV 1711
                    |.:.:..:..|....|       .|:..|.:|..:.:     :|||::.|.||..:|
 Worm  1454 --------CRQKSKSDQNLASNDDIVDNLGGMKRSLSGSRILQLN-----ILVPEVLEERVGVVV 1505

Human  1712 SKKGYLHFLEPHTSGWARRFVVVRRPYAYMYNSDKDTVERFVLNLATAQVEYSEDQQAMLKTPNT 1776
            |||||::|||..|.||.||:|:|||||..::..|:|.|.|.::|||.|::|:|||||||:|.|||
 Worm  1506 SKKGYMNFLEEKTQGWTRRWVIVRRPYILLFRDDRDLVIRGIINLANARIEHSEDQQAMVKVPNT 1570

Human  1777 FAVCTEHRGILLQAASDKDMHDWLYAFNPLLAGTIR 1812
            |:|||..||.|:|.....:|:|||||.|||:||.::
 Worm  1571 FSVCTNQRGFLMQMMPGDEMYDWLYAINPLMAGQMK 1606

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
KIF1A	XP_047300774.1	KISc_KIF1A_KIF1B	4..361	CDD:276816	257/357 (72%)
		Kinesin_assoc	358..549	CDD:465047	82/194 (42%)
		FHA_KIF1A	525..639	CDD:438778	60/113 (53%)
		ERM_helical	658..>711	CDD:466641	26/52 (50%)
		KIF1B	839..886	CDD:463574	12/51 (24%)
		DUF3694	1275..1431	CDD:463599	84/158 (53%)
		PH_KIFIA_KIFIB	1706..1808	CDD:269939	59/101 (58%)
unc-104	NP_001022041.2	KISc_KIF1A_KIF1B	2..354	CDD:276816	257/357 (72%)
		Kinesin_assoc	351..488	CDD:465047	82/194 (42%)
		FHA_KIF1	464..564	CDD:438757	55/104 (53%)
		Rcc_KIF21	595..652	CDD:425381	27/56 (48%)
		KIF1B	829..875	CDD:463574	15/57 (26%)
		DUF3694	1116..1260	CDD:463599	83/157 (53%)
		PH_KIFIA_KIFIB	1500..1602	CDD:269939	59/101 (58%)