Protein Alignment CROT and ChAT

DIOPT Version :10

• Sequence 1: NP_001137407.1
• Gene: CROT / 54677
• HGNCID: 2366
• Length: 640
• Species: Homo sapiens
• Sequence 2: NP_477004.5
• Gene: ChAT / 42249
• FlyBaseID: FBgn0000303
• Length: 721
• Species: Drosophila melanogaster
• Alignment Length: 704
• Identity: 194/704 - (27%)
• Similarity: 324/704 - (46%)
• Gaps: 135/704 - (19%)

Human     6 AKSTEERTFQYQDSLPSLPVPSLEESLKKYLESVTRTCYQIRGLDPDAKRGFLDLTREGIQVKPF 70
            |:|.:|  |.:.|:||.:|||:|:|::..|          ||.|:                  |.
  Fly    76 AESVDE--FGFPDTLPKVPVPALDETMADY----------IRALE------------------PI 110

Human    71 ANQEEYKKTEEIVQKFQS--GIGEKLHQKLLERAKGKRNWLEEWWLNVAYLDVRIPSQLNVNFAG 133
            ....:.::|:|::::|.:  |||.:|||.||::.:.:.||...:|||..|:|:|||..:|.|
  Fly   111 TTPAQLERTKELIRQFSAPQGIGARLHQYLLDKREAEDNWAYYYWLNEMYMDIRIPLPINSN--- 172

Human   134 PAAHFEHYWPPKE----------GTQLERGSITLWHNLNYWQLLRKEKVPVHKVG----NTPLDM 184
            |...|    ||:.          ..:|..|.      |::.::|...::|:.:..    |.||.|
  Fly   173 PGMVF----PPRRFKTVHDVAHFAARLLDGI------LSHREMLDSGELPLERAASREKNQPLCM 227

Human   185 NQFRMLFSTCKVPGITRDS--IMNYFRTESEGRSPNHIVVLCRGRAF--VFDVIHEGCLVTPPEL 245
            .|:..|..:|:.||:.:||  :.:..|...|.|   |:||:||.:.:  |......|.| :..|:
  Fly   228 AQYYRLLGSCRRPGVKQDSQFLPSRERLNDEDR---HVVVICRNQMYCVVLQASDRGKL-SESEI 288

Human   246 LRQLTYIHKKCHSEPDGP-GIAALTSEERTRWAKAREYLIGLDPENLALLEKIQSSLLVYSMED- 308
            ..|:.|:.......|..| .:..||:|.|:.||:.|| ::..|..|...||.|:::.:|..:::
  Fly   289 ASQILYVLSDAPCLPAKPVPVGLLTAEPRSTWARDRE-MLQEDERNQRNLELIETAQVVLCLDEP 352

Human   309 ------------SSPHV---TPEDYSEIIAAILIGDPTV-----RWGDKSYNLISFSNGVFGCNC 353
                        ::|.|   ...|.:.:...::.|..:.     ||.||:..||..::|.:|...
  Fly   353 LAGNFNARGFTGATPTVHRAGDRDETNMAHEMIHGGGSEYNSGNRWFDKTMQLIICTDGTWGLCY 417

Human   354 DHAPFDAMIMVNISYYVDEKIFQNEGRWKGSEKVRDIPLPEELIFIVDEKVLNDINQAKAQYLRE 418
            :|:..:.:.:|.:...:.:||.::.....|..: ..:|.||.|.:.|..::.....||.....:.
  Fly   418 EHSCSEGIAVVQLLEKIYKKIEEHPDEDNGLPQ-HHLPPPERLEWHVGPQLQLRFAQASKSVDKC 481

Human   419 ASDLQIAAYAFTSFGKKLTKNKMLHPDTFIQLALQLAYYRLHGHPGCCYETAMTRHFYHGRTETM 483
            ..||....|.:.|:||...|:..:.||.:||||||||:|:|:|.....||:|.||.|.|||.:.:
  Fly   482 IDDLDFYVYRYQSYGKTFIKSCQVSPDVYIQLALQLAHYKLYGRLVATYESASTRRFLHGRVDCI 546

Human   484 RSCTVEAVRWCQSM-QDPSVNL-----RERQQKMLQ-----------------AFAKHNKMMKDC 525
            |:.:.||:.|.::| |....|:     ||.:::..:                 |.|:..::|...
  Fly   547 RAASTEALEWAKAMCQGEGANVPLESDREDEEESRKVKFSIYSKDHLRELFRCAVARQTEVMVKN 611

Human   526 SAGKGFDRHLLGLLLIAKEEGLPVPELFTDPLFSKSGGGGNFVLSTSLV--------GYLRVQGV 582
            ..|.|.|..||||...:.|....:.|||.|..:..|   ..|:||||.|        ||    |.
  Fly   612 ILGNGIDIPLLGLREASIEVTGEMHELFKDESYIIS---QCFLLSTSQVACSTDSFMGY----GP 669

Human   583 VVPMVHNGYGFFYHIRDDRFVVACSAWKSCPETDAE---KLVQLTFCAFHDMIQ 633
            |.|   .|||..|:...::.|...||:.||.:|.|.   |.:|.:.....|::|
  Fly   670 VTP---RGYGCSYNPHPEQIVFCVSAFYSCEDTSASRYAKSLQDSLDIMRDLLQ 720

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CROT	NP_001137407.1	Carn_acyltransf	23..622	CDD:459926	184/674 (27%)
ChAT	NP_477004.5	Carn_acyltransf	92..710	CDD:459926	184/674 (27%)