Protein Alignment CROT and whd

DIOPT Version :10

• Sequence 1: NP_001137407.1
• Gene: CROT / 54677
• HGNCID: 2366
• Length: 640
• Species: Homo sapiens
• Sequence 2: NP_001163111.1
• Gene: whd / 36109
• FlyBaseID: FBgn0261862
• Length: 782
• Species: Drosophila melanogaster
• Alignment Length: 655
• Identity: 189/655 - (28%)
• Similarity: 307/655 - (46%)
• Gaps: 81/655 - (12%)

Human    14 FQYQDSLPSLPVPSLEESLKKYLESVTRTCYQIRGLDPDAKRGFLDLTREGIQVKPFANQEEYKK 78
            :.:|.|||.||:||:::::.:||.|                            |:|..:.|.|.:
  Fly   165 YSFQGSLPRLPLPSVKDTMTRYLRS----------------------------VRPLLDDENYTR 201

Human    79 TEEIVQKFQSGIGEKLHQKLLERAKGKRNWLEEWWLNVAYLDVRIPSQLNVNFAGPAAHFEHYWP 143
            .|.:.::|:..||:||...|:.::....|::.:||....||..|.|..:|.||.|..|.|.:.
  Fly   202 MERLAKEFEQTIGKKLQWYLILKSWWSTNYVSDWWEEYVYLRGRSPLCVNSNFYGTDAIFMNL-- 264

Human   144 PKEGTQLERGSITLWHNLNYWQLLRKEKV-PVHKVGNTPLDMNQFRMLFSTCKVPGITRDSIMNY 207
              ...|..|.:..:...||:.:|:..::: |:...|..||...|:...|:|.:|||:..|.|::|
  Fly   265 --TDKQAARAANVISLLLNFRRLIEHQELQPIMVQGMIPLCSWQYERTFNTARVPGLETDRIIHY 327

Human   208 FRTESEGRSPNHIVVLCRGRAFVFDVIHEGCLVTPPELLRQLTYIHKKCHSEPDG-PGIAALTSE 271
                   |..||||||.:|..:...:.::|.::.|.||..|:..|.|...:..:| ..:||||:.
  Fly   328 -------RDSNHIVVLHKGCYYKMLIYYKGRILRPCELQVQIEEILKGKATPVEGEEHLAALTAW 385

Human   272 ERTRWAKARE--YLIGLDPENLALLEKIQSSLLVYSMEDSSPH----VTPEDYSEIIAAILIGDP 330
            .|::||:||.  :..|:   |...|..|:|:..|.|::| .|.    ..||........:|.|:.
  Fly   386 NRSKWAEARNTFFSWGV---NQTSLRTIESAAFVLSLDD-EPFEFDLARPELLDNFGKKLLHGNG 446

Human   331 TVRWGDKSYNLISFSNGVFGCNCDHAPFDAMIMVNI--SYYVDEKI---FQNEGRWKGSEKVRDI 390
            ..||.||.:.:...:||..|.|.:|...||.|..::  :..||:.:   :...|..||:...:.
  Fly   447 YNRWFDKCFTVCVGTNGRVGFNAEHTWSDAAIASHMWENLIVDDLVSDGYDETGNTKGTPAFQP- 510

Human   391 PLPEELIFIVDEKVLNDINQAKAQYLREASDLQIAAYAFTSFGKKLTKNKMLHPDTFIQLALQLA 455
            |.|..|.:.: :..|..|.:|.....:..:::.:.......:||...|...:.||.:||:|||||
  Fly   511 PTPTRLTWDL-KPCLAQIEEATIDVTKLINEVNLRILVHQDYGKGFMKKCRISPDAYIQMALQLA 574

Human   456 YYRLHGHPGCCYETAMTRHFYHGRTETMRSCTVEAVRWCQSMQDPSVNLRERQQKMLQAFAKHNK 520
            |||..|.....||.:|||.|..|||||:|.||:|:..|.::||:|:....||.:.|..|..:|..
  Fly   575 YYRDAGRFSLTYEASMTRLFREGRTETVRPCTIESSAWVKAMQNPNTTNDERVKMMQAACDRHQL 639

Human   521 MMKDCSAGKGFDRHLLGLLLIAKEEGLPVPELFTDPLFSKSGGGGNFVLSTSLVGY--------- 576
            ..:|...|:|.||||..|.:::|.  |.|...|.:.:.|:.     :.||||...:
  Fly   640 GYQDAMCGRGIDRHLFCLYVVSKY--LEVDSPFLNEVLSEP-----WRLSTSQTPHGQTPKMDLK 697

Human   577 -----LRVQGVVVPMVHNGYGFFYHIRDDRFV-VACSAWKSCPETDAEKLVQLTFCAFHDMIQLM 635
                 :...|...|:..:|||..|.|..:..: ...||..:|.:||..:..|....|..| |:.|
  Fly   698 KHPNCISAGGGFGPVADDGYGVSYIIAGENLIFFHISAKTTCQQTDVHRFAQNISQALSD-IRSM 761

Human   636 NSTHL 640
            ...|:
  Fly   762 FEQHM 766

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CROT	NP_001137407.1	Carn_acyltransf	23..622	CDD:459926	179/626 (29%)
whd	NP_001163111.1	CPT_N	1..47	CDD:465132
		Carn_acyltransf	174..753	CDD:459926	180/630 (29%)