Protein Alignment CROT and CG5122

DIOPT Version :10

• Sequence 1: NP_001137407.1
• Gene: CROT / 54677
• HGNCID: 2366
• Length: 640
• Species: Homo sapiens
• Sequence 2: NP_609601.1
• Gene: CG5122 / 34703
• FlyBaseID: FBgn0032471
• Length: 1263
• Species: Drosophila melanogaster
• Alignment Length: 664
• Identity: 191/664 - (28%)
• Similarity: 302/664 - (45%)
• Gaps: 108/664 - (16%)

Human     3 NQLAKSTEERTFQYQDSLPSLPVPSLEESLKKYLESVTRTCYQIRGLDPDAKRGFLDLTREGIQV 67
            |...|..|.:.|      |:||   |::|:..||.|                            :
  Fly   657 NDPNKKPELKKF------PALP---LKQSIASYLSS----------------------------I 684

Human    68 KPFANQEEYKKTEEIVQKFQSGIGEKLHQKLLERAKGKRNWLEEWWLNVAYLDVRIPSQLNVNFA 132
            :||.|:||.|..:::.:||....|.||.|.|.|.|:|..|||...|...|||..:.|  |.| |:
  Fly   685 EPFLNEEELKVEQKVAKKFVDNEGAKLQQLLEEEAEGTDNWLTPRWTRSAYLTYQAP--LTV-FS 746

Human   133 GPAAHFEHYWPPKE----GTQLERGSITLWHNLNYWQLLRKEKVPVHKVGNTPLDMNQFRMLFST 193
            .|...|    |.:|    ...|...:..::....:.||:.:.|:||.::|...||.:||..:|.|
  Fly   747 SPGLSF----PIQEFKDTNDFLNFTAKAIYGMCEFKQLVDQNKIPVVQMGKHQLDNSQFGKIFGT 807

Human   194 CKVPGITRDSIMNYFRTESEGRSPNHIVVLCRGRAFVFDVIHEGCLVTPPELLRQLTYIHKKCHS 258
            .:.||...|:|..|       ...::|||:.....|...:..:...:.....||.......:|..
  Fly   808 VRKPGRFCDTIEQY-------NDADYIVVVYNNNYFKLPIYSQSGALLHAHTLRDALQDILECPI 865

Human   259 EPDGPGIAALTSEERTRWAKAREYLIGLDPE-NLALLEKIQSSLLVYSMEDSSPHVTPEDYSEII 322
            :. |.....||.:.|:.||:|  |.:...|. |...:|.|:.||.|..:::..|  ||:....|:
  Fly   866 KV-GKHFGLLTHDNRSNWAEA--YTVLCRPHGNADTVETIEQSLFVVCLDNCVP--TPKGEERIV 925

Human   323 AA--ILIG-----DPTVRWGDKSYNLISFSNGVFGCNCDHAPFDAMIMVNISYYVDEKIFQNEGR 380
            .|  :|.|     :...||.||:..||...||:.|...:|:|.|...:..:..:|..|:.:....
  Fly   926 QAHQLLHGGGVRQNSANRWMDKTIQLIVNPNGLAGFCYEHSPADCQPLAMLMDFVQLKVTEPNYG 990

Human   381 WKGSEKVRDIPLPEELIFIVDEKVLND----------IN----QAKAQYLREASDLQIAAYAFTS 431
            .:|.|              .|:||.::          ||    ||:....|..|.||:....|..
  Fly   991 CEGCE--------------ADKKVTSNLLKFQPVNECINLWLCQARRNIQRIVSQLQMNVINFEC 1041

Human   432 FGKKLTKNKMLHPDTFIQLALQLAYYRLHGHPGCCYETAMTRHFYHGRTETMRSCTVEAVRWCQS 496
            :||...|.:.|:||::||:||.||||.::|.....||:|..|.|:.|||||:||.:.|:..:..:
  Fly  1042 YGKCFIKAQGLNPDSYIQMALSLAYYSMYGKIPAQYESAHLRIFHEGRTETIRSTSNESKTFLLA 1106

Human   497 MQDPSVNLRERQQKMLQAFAKHNKMMKDCSAGKGFDRHLLGLLLIAKEEGLPVPELFTDPLFSKS 561
            ||....::.|:...:.:|...|.|::|:...|:|.||||.||..:|.|:|:|:||.|....:.:|
  Fly  1107 MQSEKASMSEKLAALQKAVDAHEKLIKEAINGQGIDRHLFGLQEMALEKGMPIPEFFRSKGYVRS 1171

Human   562 GGGGNFVLSTSLV-----GYLRVQGVVVPMVHNGYGFFYHIRDDRFVVACSAWKSCPETDAEKLV 621
               ..|.|.||.|     |::    ...|::.:|||..|:.::.:...|.||||||.|.:..:..
  Fly  1172 ---VTFQLFTSQVATSNEGFM----AYGPLLSDGYGVCYNPKESKITFAISAWKSCKEINTIRFA 1229

Human   622 QLTFCAFHDMIQLM 635
            :....:.:||.:|:
  Fly  1230 KAIKKSLNDMRKLI 1243

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CROT	NP_001137407.1	Carn_acyltransf	23..622	CDD:459926	183/629 (29%)
CG5122	NP_609601.1	PTZ00449	<299..668	CDD:185628	3/10 (30%)
		Carn_acyltransf	672..1234	CDD:459926	182/632 (29%)