Protein Alignment GTPBP2 and CG2017

DIOPT Version :10

• Sequence 1: NP_061969.3
• Gene: GTPBP2 / 54676
• HGNCID: 4670
• Length: 602
• Species: Homo sapiens
• Sequence 2: NP_649603.3
• Gene: CG2017 / 40733
• FlyBaseID: FBgn0037391
• Length: 643
• Species: Drosophila melanogaster
• Alignment Length: 581
• Identity: 282/581 - (48%)
• Similarity: 385/581 - (66%)
• Gaps: 45/581 - (7%)

Human    45 NGRNRGGKANNPPY------------------------------LPPEAEDGNIEYKLKLVNPSQ 79
            ||.:.||.:::..|                              ||||.:.||:||||||||||:
  Fly    62 NGNSSGGGSSSSDYETDANANECSVVSGMPTERGNLIFDFEQGMLPPEPQLGNVEYKLKLVNPSK 126

Human    80 YRFEHLVTQMKWRLQEGRGEAVYQIGVEDNGLLVGLAEEEMRASLKTLHRMAEKVGADITVLRER 144
            .|||||||||||||:||.|||:|:|||.|.|.|.||::::|.|||.||.:||..:||..:|||.:
  Fly   127 QRFEHLVTQMKWRLREGNGEAIYEIGVSDAGYLQGLSDKDMNASLTTLKQMAHSLGASTSVLRRK 191

Human   145 EVDYDSDMPRKITEVLVRKVPDNQQFLDLRVAVLGNVDSGKSTLLGVLTQGELDNGRGRARLNLF 209
            .:    ...|.:.||||||:||:|..:::||||||..|:|||||||||||.|||||.||||||:|
  Fly   192 TI----AARRAVAEVLVRKIPDDQHNIEVRVAVLGGADAGKSTLLGVLTQDELDNGHGRARLNMF 252

Human   210 RHLHEIQSGRTSSISFEILGFNSKGEVVN--YSDSRTAEEICESSSKMITFIDLAGHHKYLHTTI 272
            ||:|||||||||.||.|.|||::.|.|||  |::..|||||.:.|||::||:|||||.:|:.||:
  Fly   253 RHMHEIQSGRTSCISHETLGFDALGNVVNYKYNEMMTAEEISDRSSKLVTFMDLAGHRRYMRTTV 317

Human   273 FGLTSYCPDCALLLVSANTGIAGTTREHLGLALALKVPFFIVVSKIDLCAKTTVERTVRQLERVL 337
            ..|:.|.|..|:|:|||.:|...||.|||.:..||.:|||::|:|.|:   |:.:.||::|..:|
  Fly   318 QALSGYSPHYAMLVVSAGSGCNDTTEEHLAIVRALDMPFFVLVTKTDI---TSPDATVQELCNLL 379

Human   338 KQPGCHKVPMLVTSEDDAVTAAQQFAQSPNVTPIFTLSSVSGESLDLLKVFLNILPPLTNSKEQE 402
            ...||.|||.:||:.|:|::|... ..|.|:.|||.:|:|:|..|:|:..||.:|.|..::.|::
  Fly   380 TTIGCRKVPFVVTNTDEAISAGSN-QISENIVPIFCVSNVTGTGLNLVTKFLYVLSPGISNAEKD 443

Human   403 ELMQQLTEFQVDEIYTVPEVGTVVGGTLSSGICREGDQLVVGPTDDGCFLELRVCSIQRNRSACR 467
            .|.|:..|||||||:.|.:||.||||.|..|:..|...:.:||..||.|..:.|.:|.||::.||
  Fly   444 RLEQESCEFQVDEIFRVSDVGPVVGGLLVQGVLTENMAMKIGPLPDGSFHPVTVNTIHRNKAPCR 508

Human   468 VLRAGQAATLALG-DFDRALLRKGMVMVSPEMN----PTICSVFEAEIVLLFHATTFRRGFQVTV 527
            |:||||:|:|:.. |.|...||.|||::....|    |.....|:|::.:|||||....|||.||
  Fly   509 VVRAGQSASLSFSMDQDVPTLRSGMVLLGDIGNSLDEPYGTFFFQAKVSVLFHATAIYVGFQTTV 573

Human   528 HVGNVRQTAVVEKIHAKDKLRTGEKAVVRFRFLKHPEYLKVGAKLLFREGVTKGIGHVTDV 588
            |:|::|||||:..|...::|.|.:.|.|.|.|:.||||::.|.::|||||.:||||.||.|
  Fly   574 HIGSIRQTAVIRGIMGGERLGTNDCASVMFEFVGHPEYVRPGMRILFREGTSKGIGVVTQV 634

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
GTPBP2	NP_061969.3	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	16..64		9/48 (19%)
		GTPBP1_like	174..394	CDD:206728	120/221 (54%)
		GTPBP_II	409..495	CDD:293895	42/86 (49%)
		GTPBP_III	501..588	CDD:294007	42/86 (49%)
CG2017	NP_649603.3	GTPBP1_like	217..436	CDD:206728	120/222 (54%)
		GTPBP_II	450..536	CDD:293895	42/85 (49%)
		GTPBP_III	547..634	CDD:294007	42/86 (49%)