DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment LRRN3 and Fili

DIOPT Version :9

Sequence 1:	NP_001093128.1	Gene:	LRRN3 / 54674	HGNCID:	17200	Length:	708	Species:	Homo sapiens
Sequence 2:	NP_001369108.1	Gene:	Fili / 5740472	FlyBaseID:	FBgn0085397	Length:	789	Species:	Drosophila melanogaster

Alignment Length:	398	Identity:	112/398 - (28%)
Similarity:	188/398 - (47%)	Gaps:	38/398 - (9%)

- Green bases have known domain annotations that are detailed below.

Human     8 IHVLLGLAITTLVQAVDKKVDCPRLCTCEIRPWFTPRSIYMEA-STVDCNDLGLLTFPARLPANT 71
            |.|||.|.:|.::...:....||..|.|          :..|| |...|.|..|...|.:|...|
  Fly    21 IPVLLLLLLTLVILPPETTAFCPSKCQC----------LGGEANSRALCVDAALEDVPIQLNPET 75

Human    72 QILLLQTNNIAKIEYSTDFPVNLTGLDLSQNNLSSVTNINVKKMPQLLSVYLEENKLTELPEKCL 136
            :.:.|..|.|..:|:|..|.:.|..||||||.:.::.:.|.:...:|.::.|..|.::.|.:...
  Fly    76 KYINLTVNRIRTLEFSLPFYMKLEILDLSQNIIETLGSKNFEYQSELRTLNLSRNLVSSLHKHAF 140

Human   137 SELSNLQELYINHNLLSTISPGAFIGLHNLLRLHLNSNRLQMINSKWFDALPNLEILMIGENPII 201
            ..|:||..|.::.|.:.|:.|.|...|.:|:.|.|.:|.:..:....|..:..||:|:...|.::
  Fly   141 KGLTNLLLLDLSFNRIETVHPTALSDLASLVELDLTNNNIVSLEDNCFKGMNTLEVLVFRNNRLL 205

Human   202 RIKDMN------------------------FKPLINLRSLVIAGINLTEIPDNALVGLENLESIS 242
            .:...|                        |:.|..|.:|.:.|..::|:..:|..||.:|:.:.
  Fly   206 DVPASNLWHLHALKSLDMSLNLVEFVRNDSFEGLKELLALSVQGNVMSELDLSAFEGLISLKHLD 270

Human   243 FYDNRLIKVPHVALQKVVNLKFLDLNKNPINRIRRGDFSNMLHLKELGINNMPELISIDSLA-VD 306
            ..||.|..||...|.|:.||.:|:|..|..:::....|.|:.||:||.::.:..|..|||.| ||
  Fly   271 LSDNNLTMVPTQQLSKLSNLTYLNLGGNRFSQLPAVAFLNLFHLRELHLSRLDFLQRIDSRAFVD 335

Human   307 NLPDLRKIEATNNPRLSYIHPNAFFRLPKLESLMLNSNALSALYHGTIESLPNLKEISIHSNPIR 371
            | ..|:.:...|||:||.|....|...|.:..:.:.||:|..||.... .:..|:::.:..||::
  Fly   336 N-THLQTLHLNNNPQLSDIPMRLFQGNPNILEVYMQSNSLQTLYSAQF-PVDQLQKLYLGDNPLQ 398

Human   372 CDCVIRWM 379
            |:|.:.|:
  Fly   399 CNCSLLWL 406

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
LRRN3	NP_001093128.1	LRRNT	28..72	CDD:214470	12/44 (27%)
		LRR 1	70..91		6/20 (30%)
		leucine-rich repeat	72..93	CDD:275380	6/20 (30%)
		LRR	<75..355	CDD:227223	87/304 (29%)
		LRR 2	93..114		8/20 (40%)
		leucine-rich repeat	94..117	CDD:275380	8/22 (36%)
		LRR 3	117..138		4/20 (20%)
		leucine-rich repeat	118..141	CDD:275380	5/22 (23%)
		LRR 4	141..162		7/20 (35%)
		leucine-rich repeat	142..165	CDD:275380	7/22 (32%)
		LRR 5	165..186		5/20 (25%)
		leucine-rich repeat	166..189	CDD:275380	5/22 (23%)
		LRR 6	189..210		6/44 (14%)
		leucine-rich repeat	190..213	CDD:275380	7/46 (15%)
		LRR 7	213..234		5/20 (25%)
		leucine-rich repeat	214..237	CDD:275380	7/22 (32%)
		LRR 8	237..258		7/20 (35%)
		leucine-rich repeat	238..261	CDD:275380	8/22 (36%)
		LRR 9	261..282		6/20 (30%)
		leucine-rich repeat	262..285	CDD:275380	6/22 (27%)
		LRR 10	285..304		8/18 (44%)
		leucine-rich repeat	286..310	CDD:275380	11/24 (46%)
		LRR 11	310..332		8/21 (38%)
		leucine-rich repeat	311..333	CDD:275380	8/21 (38%)
		LRR 12	335..358		5/22 (23%)
		leucine-rich repeat	336..359	CDD:275380	5/22 (23%)
		PCC	341..>442	CDD:188093	11/39 (28%)
		Ig	437..513	CDD:325142
		fn3	526..593	CDD:306538
Fili	NP_001369108.1	leucine-rich repeat	75..97	CDD:275378	7/21 (33%)
		leucine-rich repeat	98..121	CDD:275380	8/22 (36%)
		LRR_8	120..180	CDD:404697	17/59 (29%)
		leucine-rich repeat	122..145	CDD:275380	5/22 (23%)
		leucine-rich repeat	146..169	CDD:275380	7/22 (32%)
		LRR	<161..>354	CDD:227223	55/193 (28%)
		leucine-rich repeat	170..193	CDD:275380	5/22 (23%)
		leucine-rich repeat	194..217	CDD:275380	5/22 (23%)
		leucine-rich repeat	218..265	CDD:275380	9/46 (20%)
		leucine-rich repeat	266..289	CDD:275380	8/22 (36%)
		leucine-rich repeat	290..313	CDD:275380	6/22 (27%)
		leucine-rich repeat	314..338	CDD:275380	11/24 (46%)
		LRR_8	337..397	CDD:404697	16/60 (27%)
		leucine-rich repeat	339..360	CDD:275380	8/20 (40%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		mtm8524
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24373
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	3.010