DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment INO80 and dom

DIOPT Version :10

Sequence 1:NP_060023.1 Gene:INO80 / 54617 HGNCID:26956 Length:1556 Species:Homo sapiens
Sequence 2:NP_001286676.1 Gene:dom / 45655 FlyBaseID:FBgn0020306 Length:3233 Species:Drosophila melanogaster


Alignment Length:1510 Identity:408/1510 - (27%)
Similarity:634/1510 - (41%) Gaps:413/1510 - (27%)


- Green bases have known domain annotations that are detailed below.


Human    82 GETSGAGSSGMLNTYSLNG---------------------VLQSESKCDKGNLYNFSKLKK---- 121
            |.|.|..:||.|.:.:|.|                     |:|..|:..:..|:...:|.|    
  Fly   484 GLTPGTPTSGSLLSPALGGGSGTPNSAAQEFSFKAKQEVYVMQRISELQREGLWTERRLPKLQEP 548

Human   122 -----------------------SRKWLKS-------ILLSDESSEADSQSEDDDEEELNLSR-- 154
                                   .|||.|:       ::......:|.:....:..:||.|.|  
  Fly   549 SRPKAHWDYLLEEMVWLAADFAQERKWKKNAAKKCAKMVQKYFQDKATAAQRAEKAQELQLKRVA 613

Human   155 ----EEL----HNMLRLHKYKKLHQNKYSKDKELQQYQYYSAGLLSTYDPFYEQQRHLLGPKKKK 211
                .|:    .|:.:|.:||  ||.|. ::|..|....:.:.::...:.|.:|   |:....|.
  Fly   614 SFIAREVKSFWSNVEKLVEYK--HQTKI-EEKRKQALDQHLSFIVDQTEKFSQQ---LVEGMNKS 672

Human   212 FKEEKKLKAKLKKVKKKRRRDEELSSEESPRRHHHQTKVFAKFSHDAPPPGTKKKHLSIEQLNAR 276
            ..:...|.:. :....||..|::...|..   .....:..||...||  ...|::..::    |:
  Fly   673 VADTPSLNSS-RLTSPKRESDDDFRPESG---SEDDEETIAKAEEDA--ADVKEEVTAL----AK 727

Human   277 RRKVWLSIVKKELPKANKQKASARNLFLTNSRKLAHQCMKEVRRAALQAQ--KNCKETLPRARRL 339
            ..::.......:||..          :|.|..||    |||.:.:|::.:  .:..::...|:..
  Fly   728 ESEMDFDDFLNDLPPG----------YLENRDKL----MKEEQSSAIKTETPDDSDDSEFEAKEA 778

Human   340 TKEMLLYWKKYEKVEKE--HRKRA-EKEALEQRKLDEEMREAKRQQ------RKLNFLITQTELY 395
            :.:......|.|:.|:|  |:|.. |.||.....:::.:.:.|.:|      |||  .....|| 
  Fly   779 SDDDENTISKQEEAEQEIDHKKEIDELEADNDLSVEQLLAKYKSEQPPSPKRRKL--APRDPEL- 840

Human   396 AHFMSRKRDMGHDGIQEEILRKLEDSSTQRQIDIGGGVVVNITQEDYDSNHFKAQALKNAENAYH 460
                    |...|....:...:.||::|:.:.|: ..|..:...|:.|......::|        
  Fly   841 --------DSDDDSTAVDSTEESEDAATEDEEDL-STVKTDTDMEEQDEQEDGLKSL-------- 888

Human   461 IHQARTRSFDEDAKESRAAALRAANKSGTG---FGESYSLANPSIRAGEDI-------PQPTIFN 515
                   ..|.||....|.:...|..||..   ..::.:||......|..:       |.|.:..
  Fly   889 -------MADADATSGAAGSGSTAGASGNKDDMLNDAAALAESLQPKGNTLSSTNVVTPVPFLLK 946

Human   516 GKLKGYQLKGMNWLANLYEQGINGILADEMGLGKTVQSIALLAHLAERENIWGPFLIISPASTLN 580
            ..|:.||..|::||..:.|:.:|||||||||||||:|:||||||||..:..|||.||:.|:|.:.
  Fly   947 HSLREYQHIGLDWLVTMNERKLNGILADEMGLGKTIQTIALLAHLACAKGNWGPHLIVVPSSVML 1011

Human   581 NWHQEFTRFVPKFKVLPYWGNPHDRKVIRRFWSQKTLYTQDAPFHVVITSYQLVVQDVKYFQRVK 645
            ||..||.::.|.||:|.|:|:..:||:.|..|      |:...|||.||||:|||||.:.|:|.|
  Fly  1012 NWEMEFKKWCPGFKILTYYGSQKERKLKRVGW------TKPNAFHVCITSYKLVVQDQQSFRRKK 1070

Human   646 WQYMVLDEAQALKSSSSVRWKILLQFQCRNRLLLTGTPIQNTMAELWALLHFIMPTLFDSHEEFN 710
            |:|::|||||.:|:..|.||::||.|....||||||||:||.:.|||:|:||:||.:|.||.||.
  Fly  1071 WKYLILDEAQNIKNFKSQRWQLLLNFSTERRLLLTGTPLQNDLMELWSLMHFLMPYVFSSHREFK 1135

Human   711 EWFSKDIESHAENKSAIDENQLSRLHMILKPFMLRRIKKDVENELSDKIEILMYCQLTSRQKLLY 775
            ||||..:....|.....:|..::|||.:::||:|||:||:||.::..|.|.::.|:|::||:.||
  Fly  1136 EWFSNPMTGMIEGNMEYNETLITRLHKVIRPFLLRRLKKEVEKQMPKKYEHVITCRLSNRQRYLY 1200

Human   776 QALKNKISIEDLLQSSMGSTQQAQNTTSSLMNLVMQFRKVCNHPELFERQETWSPFHISLKPYHI 840
            :...::....:.||:         ....|::|::||.|||||||.:||.:.|.|||.:....:|.
  Fly  1201 EDFMSRAKTRETLQT---------GNLLSVINVLMQLRKVCNHPNMFEARPTISPFQMDGITFHT 1256

Human   841 SKFIYRHGQIRVFNHSRDRWLRVL-----------------------------------SPFAPD 870
            .:.:....:...|.......|.:|                                   :|..|:
  Fly  1257 PRLVCDIMEYDPFTQINLETLNLLLLHLEQTMTAYVSHKSRLLAPPRKLIEDIDTAPLPAPRCPN 1321

Human   871 YIQRSLFHRKGINEESCFSFLRF------IDISPA---------EMANLMLQG-LLARWLALF-- 917
            ...|  ||   |...|.....|.      :..|||         .|.||:..| :|.|..|..  
  Fly  1322 GKYR--FH---IRVRSAELAQRIKLNAVKVGASPAMRLEGSKIMPMRNLLPSGRVLKRVSASINP 1381

Human   918 -----------------------------LSLKASYRLHQLRSW-GAPEGESHQRYLRN-KDFL- 950
                                         ||:.::.:|...||. .||......:.::: |.|. 
  Fly  1382 VNMALKPVVINSVVTTTSSSTTASSPTGALSVLSNSKLLGARSQINAPTPAKVAKTMQDGKPFFY 1446

Human   951 ---------LGVNFPLSFPNLCSC----------------------PLLKSLVFSSHCK------ 978
                     .|....|:.....|.                      |::|.|  ::|.|      
  Fly  1447 LTPATNSGAAGARLTLTSKTTASASTTTSRTTVTASTTSGQQLIRDPIVKDL--ATHVKSTVQKQ 1509

Human   979 --------------AVSGYSDQ------------------VVHQRRS------------------ 993
                          |...|..|                  ::::||:                  
  Fly  1510 SIANGKTEPEEETEAEDPYKVQELIQMRKEQRLAALKRMAMINRRRTDATPIYGEDCREAIQRCM 1574

Human   994 -ATSSLRR-----------C----------LLTELPSF-------------LCVASPRVTAVPLD 1023
             ||.||:|           |          |...|.||             ..:..|.|.|..:.
  Fly  1575 QATRSLKRSTWQTRGYANCCTAMAHRNGWSLNHLLKSFEERCADLKPVFANFVIYVPSVCAPRIR 1639

Human  1024 SYCNDRSA---EYERRVLK-EGGSLAAKQCLLNGAPELAADWLNRRSQFFPEPAGGLWSIRPQNG 1084
            .|..:.|:   ::|:|:.. ...:|..|..||:..       ::..:..||:|            
  Fly  1640 RYVQNLSSTHWQHEQRIENIVDQALRPKLALLHPI-------ISEMTTKFPDP------------ 1685

Human  1085 WSFIRIPGKESLIT-DSGKLYALDVLLTRLKSQGHRVLIYSQMTRMIDLLEEYMVYRKHTYMRLD 1148
                      .||. |.|||..:|.||.:||..||||||::|||:|:|:||.::.|..|.|:|||
  Fly  1686 ----------RLIQYDCGKLQTMDRLLRQLKVNGHRVLIFTQMTKMLDVLEAFLNYHGHIYLRLD 1740

Human  1149 GSSKISERRDMVADFQNRNDIFVFLLSTRAGGLGINLTAADTVIFYDSDWNPTVDQQAMDRAHRL 1213
            ||:::.:|:.::..|.....||.|:||||:||:|||||.||||||||||||||:|.||.||.||:
  Fly  1741 GSTRVEQRQILMERFNGDKRIFCFILSTRSGGVGINLTGADTVIFYDSDWNPTMDAQAQDRCHRI 1805

Human  1214 GQTKQVTVYRLICKGTIEERILQRAKEKSEIQRMVISGGNFKPDTLKPKEVVSLLLDDEELEKKL 1278
            |||:.|.:|||:.:.|||..||::|.:|..:..|.|.||||.....|...:..|...::.     
  Fly  1806 GQTRDVHIYRLVSERTIEVNILKKANQKRMLSDMAIEGGNFTTTYFKSSTIKDLFTMEQS----- 1865

Human  1279 RLRQEEKRQQEETNR 1293
              .|:|..|::..|:
  Fly  1866 --EQDESSQEKSENK 1878

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
INO80NP_060023.1 Assembles INO80 complex module with putative regulatory components INO80E, INO80F, UCHL5, NFRKB, MCRS1 and IN80D. /evidence=ECO:0000269|PubMed:21303910 1..266 47/248 (19%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 46..87 2/4 (50%)
Assembles INO80 complex module consisting of conserved components ACTR8, ACTL6A and YY1. /evidence=ECO:0000269|PubMed:21303910 212..526 63/334 (19%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 219..249 4/29 (14%)
HepA 298..>830 CDD:440319 192/552 (35%)
DEXQc_INO80 518..746 CDD:350760 115/227 (51%)
Assembles INO80 complex module consisting of conserved components INO80B, INO80C, ACTR5, RVBL1, RVBL2. /evidence=ECO:0000269|PubMed:21303910 521..1556 310/985 (31%)
SF2_C_SNF 1090..1225 CDD:350180 75/135 (56%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1283..1316 3/11 (27%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1388..1408
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1420..1461
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1499..1556
domNP_001286676.1 HSA 543..614 CDD:214727 10/70 (14%)
HepA 692..>1235 CDD:440319 197/607 (32%)
DEXQc_SRCAP 949..1171 CDD:350761 115/227 (51%)
SF2_C_SNF 1685..1817 CDD:350180 76/153 (50%)
DISARM_DrmD_b <1702..>1936 CDD:468472 87/184 (47%)
HEC1 <1858..>2031 CDD:444066 5/28 (18%)
SP1-4_N 2486..>2819 CDD:425404
Blue background indicates that the domain is not in the aligned region.

Return to query results.
Submit another query.