DRSC/TRiP Functional Genomics Resources

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Protein Alignment INO80 and Etl1

DIOPT Version :10

Sequence 1:NP_060023.1 Gene:INO80 / 54617 HGNCID:26956 Length:1556 Species:Homo sapiens
Sequence 2:NP_609320.2 Gene:Etl1 / 34311 FlyBaseID:FBgn0032157 Length:844 Species:Drosophila melanogaster


Alignment Length:1117 Identity:295/1117 - (26%)
Similarity:463/1117 - (41%) Gaps:337/1117 - (30%)


- Green bases have known domain annotations that are detailed below.


Human   219 KAKLKKVKKKRRRDEELSSEESPRRHHH-----QTKVFAKFSHDAPPPGTKKKHLSIEQLNARRR 278
            |:.|..:::.|......|...||.|...     :.:|.|....|.....|.||           .
  Fly    19 KSSLSDLRQFRINKNASSVVASPSRTERVPGKKRIQVMADSDSDGNDSQTPKK-----------T 72

Human   279 KVWLSIVKKELPKANKQKASAR------------NLFLTNSRKLAHQCMKEVRRAALQAQKNCKE 331
            |:.|::.:||    .:..|:|:            :|..||         .:|..:....::||| 
  Fly    73 KLELTVKEKE----ERYMAAAKISPHFDTMAIQESLSRTN---------WDVAASVRYLRENCK- 123

Human   332 TLPRARR--LTKEMLL---------YWKKYEKVEKEHRKRAEKEALEQRKLDEEMREAKRQQRKL 385
              |:...  |.|..|.         .:...:..:.:..|:::.:..:....|.||......|||.
  Fly   124 --PKGHNGPLAKSKLKPRSNGISGGNFSDNDHSDDDDVKQSKDQVYDSDDSDSEMSTKMTGQRKK 186

Human   386 NFLITQTELYAHFMSRKRDMGHDGIQEEILRKLEDSSTQRQ----IDIGGGVVVNITQEDYDSNH 446
            .|............|.|.......:....:|...|.|..||    |.:.|. ::|..||..:..:
  Fly   187 VFQFMNEASLIELQSVKTLSEKKALAIIDVRPFSDWSDLRQKLESIRMSGD-LLNYAQELINKQN 250

Human   447 FKAQALKNAENAYHIHQARTRSFDEDAKESRAAALRAANKSGTGFGESYSLANPSIRAGEDIPQP 511
            ..|..|....|                   ..:.|..|..:|.|.                :.||
  Fly   251 TVAAILSKCNN-------------------MVSRLEKAISNGAGI----------------VEQP 280

Human   512 TIFNG--KLKGYQLKGMNWLANLYEQGINGILADEMGLGKTVQSIALLAHLAERENIWGPFLIIS 574
            .:.:.  :|..||:.|:|||..:::|.:|||||||||||||:|.||.||:|.|........||:.
  Fly   281 KLLSSGLQLADYQIIGLNWLTVMHKQEMNGILADEMGLGKTIQVIAFLAYLKENGLSQAAHLIVV 345

Human   575 PASTLNNWHQEFTRFVPKFKVLPYWGNPHDRKVIR-RFWSQKTLYTQDAPFHVVITSYQLV---V 635
            |:|||:||..|.:|:.|:..|..|.|:..:|:.:| ||  .|..:|   .|.|::|:|.:|   .
  Fly   346 PSSTLDNWEAEISRWCPELVVEKYHGSQDERRRMRGRF--AKDGFT---GFDVLLTTYHIVGSTP 405

Human   636 QDVKYFQRVKWQYMVLDEAQALKSSSSVRWKILLQFQCRNRLLLTGTPIQNTMAELWALLHFIMP 700
            ::.|.|:..|..|::.|||..||:.::.|:..|:....|.|:||||||:||.:.||.:||.|:||
  Fly   406 EERKMFRVCKLDYVIFDEAHMLKNMTTQRYANLITINARMRILLTGTPLQNNLLELISLLCFVMP 470

Human   701 TLF-DSHEEFNEWFSKDIESHAENK--SAIDENQLSRLHMILKPFMLRRIKKDVENELSDKIEIL 762
            ..| .|.|:....|:|..:|..:..  |...|.|:.|...|:|||:|||:||||...|..|:.::
  Fly   471 KFFAKSIEDIKSLFAKKGKSDGDQDEVSQFQETQIQRAKRIMKPFVLRRLKKDVLKNLPKKLSLV 535

Human   763 MYCQLTSRQKLLYQALKNKISIEDLLQSSMGSTQQAQNTTSSLMNLVMQFRKVCNHPELFERQET 827
            ....::|:||:.|..|      .|...::.|  :...::..:.:.::|:.|::.|||        
  Fly   536 EKVPMSSQQKIYYHEL------VDYYSNNKG--EVCSSSERAGIAIMMEMRRIANHP-------- 584

Human   828 WSPFHISLKPYHISKFIYRHGQIRVFNHSRDRWLRVLSPFAPDYIQRSLFHRKGINEESCFSFLR 892
                           .:.||                                            .
  Fly   585 ---------------LLMRH--------------------------------------------Y 590

Human   893 FIDISPAEMANLMLQGLLARWLALFLSLKASYRLHQLRSWGAPEGESHQRYLRNKDFLLGVNFPL 957
            |.|      ||  |:|...|     |:..:|::            :::::|:             
  Fly   591 FTD------AN--LRGFSKR-----LANASSFK------------KTNEQYI------------- 617

Human   958 SFPNLCSCPLLKSLVFSSHCKAVSGYSDQVVHQRRSATSSLRRCLLTELPSFLCVASPRVTAVPL 1022
             |..|                ||  .||..|:|                                
  Fly   618 -FEEL----------------AV--MSDFQVYQ-------------------------------- 631

Human  1023 DSYCNDRSAEYERRVLKEGGSLAAKQCLLNGAPELAADWLNRRSQFFPEPAGGLWSIRPQNGWSF 1087
                                       ::|            :.:|:.                 
  Fly   632 ---------------------------MMN------------KHEFYD----------------- 640

Human  1088 IRIPGKESLITDSGKLYALDVLLTRLKSQGHRVLIYSQMTRMIDLLEEYMVYRKHTYMRLDGSSK 1152
            ::||  ::||.||||...||.||.:||::|||||::||.|.|:|::|||:..||..:.||||::.
  Fly   641 VKIP--DNLICDSGKFLYLDTLLPKLKAEGHRVLLFSQFTMMLDIVEEYLRIRKFGFCRLDGATA 703

Human  1153 ISERRDMVADFQNRNDIFVFLLSTRAGGLGINLTAADTVIFYDSDWNPTVDQQAMDRAHRLGQTK 1217
            ::.|:|::.||...:.||||||||:|||:|||||||||.:.:|.|:||..|:||.||.||:||.:
  Fly   704 VNVRQDLITDFNGDDSIFVFLLSTKAGGVGINLTAADTCVIHDIDFNPYNDKQAEDRCHRMGQQR 768

Human  1218 QVTVYRLICKGTIEERILQRAKEKSEIQRMVISGGNFKPDTLKPKEVVSLLLDDEELEKKLRLRQ 1282
            .||:||||.:.||||.||..|:||.::::.:.|  |.|.:..:.:.||.||.....|:|.    |
  Fly   769 PVTIYRLISESTIEEGILMAAEEKLKLEKDITS--NEKGEVHEQRCVVKLLTTALGLDKD----Q 827

Human  1283 EEKRQQEETNRV 1294
            ||:......|.:
  Fly   828 EEQLNNSLNNSI 839

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
INO80NP_060023.1 Assembles INO80 complex module with putative regulatory components INO80E, INO80F, UCHL5, NFRKB, MCRS1 and IN80D. /evidence=ECO:0000269|PubMed:21303910 1..266 11/51 (22%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 46..87
Assembles INO80 complex module consisting of conserved components ACTR8, ACTL6A and YY1. /evidence=ECO:0000269|PubMed:21303910 212..526 62/340 (18%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 219..249 7/34 (21%)
HepA 298..>830 CDD:440319 157/567 (28%)
DEXQc_INO80 518..746 CDD:350760 96/234 (41%)
Assembles INO80 complex module consisting of conserved components INO80B, INO80C, ACTR5, RVBL1, RVBL2. /evidence=ECO:0000269|PubMed:21303910 521..1556 235/781 (30%)
SF2_C_SNF 1090..1225 CDD:350180 74/134 (55%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1283..1316 3/12 (25%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1388..1408
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1420..1461
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1499..1556
Etl1NP_609320.2 ComEA <192..233 CDD:441164 7/40 (18%)
HepA <276..795 CDD:440319 225/761 (30%)
Blue background indicates that the domain is not in the aligned region.

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