DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Mast3 and dop

DIOPT Version :9

Sequence 1:	XP_006509770.2	Gene:	Mast3 / 546071	MGIID:	2683541	Length:	1336	Species:	Mus musculus
Sequence 2:	NP_001261884.1	Gene:	dop / 39686	FlyBaseID:	FBgn0267390	Length:	2139	Species:	Drosophila melanogaster

Alignment Length:	1767	Identity:	659/1767 - (37%)
Similarity:	861/1767 - (48%)	Gaps:	468/1767 - (26%)

- Green bases have known domain annotations that are detailed below.

Mouse     5 SLLRR----------RGLQKELSLPRRGRGLSPSSQSPCL--------LSPGSPCSPCSPSLGLQ 51
            :|||:          |.:..|.|...|.|..|....:|||        |:...|..|  |..|..
  Fly   202 ALLRKISYQQHTNSLRAVSGETSNLLRMRHSSLGKSAPCLTGNYFRHELTAPLPVQP--PGFGAS 264

Mouse    52 PWS----CRSG-----------------------------------------NRKSLVVGTPSPT 71
            |..    .|||                                         :|.|||..:.:..
  Fly   265 PLGGHNISRSGSCAGIGLAKHHHHHHLHGVVMRGSAGGGAGSGGGSSSGVAHHRLSLVTNSAAVA 329

Mouse    72 L---SRPLSPLSVPTAGNSPLDSPRNFSAAAAISFPFARSHLSHGDRADGRRWSLASLPSSGYGT 133
            .   ||..||.|.     ||:||||..|.......|..|.....|..|||||||:||||||||||
  Fly   330 AAGGSRTHSPYSA-----SPVDSPRLNSPMPFAFAPIKRIASCRGVVADGRRWSVASLPSSGYGT 389

Mouse   134 NTPSSTVSSSSSSRERLHQL-----PFQPTADE---------LRFLSKH---------------- 168
            ...||.:||..||:|.|:||     |....||.         ...|.:|
  Fly   390 TPGSSNLSSQCSSQEGLNQLAHNIPPGVQEADAAAVAAGACCAEHLKQHCPKHCALLLAVSQKQL 454

Mouse   169 ----------------------------------------------FRSSESVVDEDGGR-SPRL 186
                                                          ..||.|...:.||| ||..
  Fly   455 TPQPPKPTQLQPQKSMTAACVNCCAELSVTCGGQQAGGGAANGGSSANSSGSSAMQVGGRMSPYF 519

Mouse   187 RPRSRSLSPGRTSGTFDNEIVMMNHVYRERFPKATAQMEGRLQDFLAAFAPGDRLALADG--VLG 249
            ||||||||....|...||||.:||.:|:|||||||.|||.||:.|:.........:..|.  ::.
  Fly   520 RPRSRSLSSPSRSPIVDNEIAVMNTLYKERFPKATQQMEERLKLFINENKSAACNSFRDSQPIVR 584

Mouse   250 FIHHQIVELARDCLAKSGEALVTSRYFLEMQDKLERLLQDAHERSD--SAEVGFIVQLVRKLLII 312
            |:|||::|:|||||.||...|:||:||.|:.:.|||||.:..|:|.  :||:..:   ::|||:|
  Fly   585 FVHHQVLEMARDCLHKSEAKLITSQYFYELSENLERLLVETKEKSPEAAAELNGV---IKKLLLI 646

Mouse   313 ISRPARLLECLEFDPEEFYHLLEAAEGQAREDQGVKTDLPRYIIRQLGLAKDPLEEIQPLNDLDE 377
            |||||||||||||||:|||.|||||||.|:....:|.|:|:|||.:|||.:||:.|:|  .:|.|
  Fly   647 ISRPARLLECLEFDPQEFYELLEAAEGHAKAMPVIKADIPQYIIHKLGLNRDPIAELQ--QELRE 709

Mouse   378 SQ------------PPAPG------SP-------------------------------------- 386
            :|            |..||      ||
  Fly   710 TQQMCSEQVTVDADPLHPGGSLLLNSPLTSAAKQLSSLALDAIAMDSGSGTATPQQPPQTPVATC 774

Mouse   387 --------------ESRG-----LGGPSRRK------------------------PCESDFETIK 408
                          |.:|     :||.|..|                        |.|:||:.:|
  Fly   775 DTAPSFALAISQMNEEKGGSSSAVGGGSSSKVAGAEGITGGSAATATGSGAQQPSPQENDFDIVK 839

Mouse   409 LISNGAYGAVYLVRHRDTRQRFAIKKINKQNLILRNQIQQVFVERDILTFAENPFVVGMFCSFET 473
            |||||||||||||:|:.||||||:|||||.|||||||::|||.|||||:||:|||||.|:|||||
  Fly   840 LISNGAYGAVYLVKHKTTRQRFAMKKINKNNLILRNQVEQVFAERDILSFADNPFVVSMYCSFET 904

Mouse   474 RRHLCMVMEYVEGGDCATLLKNMGPLPVDMARMYFAETVLALEYLHNYGIVHRDLKPDNLLITSL 538
            ::|||:||||||||||.|||||:||||.||||.||||||||:||||:||||||||||||||||:|
  Fly   905 KKHLCLVMEYVEGGDCGTLLKNIGPLPADMARFYFAETVLAVEYLHSYGIVHRDLKPDNLLITAL 969

Mouse   539 GHIKLTDFGLSKIGLMSMATNLYEGHIEKDAREFVDKQVCGTPEYIAPEVIFRQGYGKPVDWWAM 603
            ||||||||||||:||||:|||||||:|:.:.|:|.||||.|||||||||||.|||||||||||:|
  Fly   970 GHIKLTDFGLSKMGLMSLATNLYEGYIDSETRQFSDKQVYGTPEYIAPEVILRQGYGKPVDWWSM 1034

Mouse   604 GVILYEFLVGCVPFFGDTPEELFGQVVSDEIMWPEGDE-ALPLDAQDLITRLLRQSPMDRLGT-G 666
            |:||||||:|||||||:|.||||...|:|:|.||:.:: .:..:|:|:|::||:|:|.||||| .
  Fly  1035 GIILYEFLIGCVPFFGETTEELFAHTVNDDIEWPDSEDWPVQAEAKDIISQLLQQNPRDRLGTQS 1099

Mouse   667 GTHEVKQHPFFLALDWAGLLRHKAEFVPQLEAEDDTSYFDTRSERYRH-LGSED-DETNDE---- 725
            |..|:|:|.:||.:||..|||.||||||||..:|||||||||.:||.| ||.|| |:|:|.
  Fly  1100 GALEMKEHEYFLGMDWNSLLRQKAEFVPQLSHDDDTSYFDTRMDRYNHDLGGEDTDDTDDTPVFG 1164

Mouse   726 ESSTEIPQFSSCSHRFSKVYSSSEFLAVQPT--------PTFAERS---------------FSED 767
            ..::..||:....:.:|:..:.:.....:||        |:.|:.:               ....
  Fly  1165 SFNSYTPQYRKQHYSWSRHATPTSTDGAKPTGPPPLSSLPSRAQETPAATVGATSTGALPKLKSG 1229

Mouse   768 REDGWGQSLGDRGRRLSAD---------LRLRSWTPASSCQPSSCQTDRGPSPSLLS--TISLDV 821
            ...|.|...|......|.|         .:||....:|||.......|....|.||.  ||..|.
  Fly  1230 MGSGSGSGSGSGSGSASHDGVVNKFLNTPQLRKLDLSSSCLKVPSTPDADYLPELLHNVTIGNDA 1294

Mouse   822 ---MPKFAFSSEDEGASSGPAD----PQKPVFILGEPDPPPPT--------TPVTPKPCNLSADT 871
               |.|......:.||:.....    |.....|:..|..||||        ||.|....:.|..|
  Fly  1295 ELRMLKHYLQQPNPGATQRMQQRHSMPPNTTTIISTPATPPPTQTQATMAATPPTATVGSFSRST 1359

Mouse   872 AVLSHA-------RLRSNSTG--ARHSTPR--------PLDAGRG--RRLGGSRDPGP----EKP 913
            ...|..       ::.....|  ||...||        .:.||..  ..:...|:..|    .:|
  Fly  1360 PESSQTDSDDFSPQINRKRKGVCARDILPRFSISIEDETISAGSSSTENMNLPREQSPLALQHQP 1424

Mouse   914 RASPGGSGG---------RVPKSASVSALSLIITADDGSGGP----LMSPLSPRSLSSNPSSRDS 965
            ::..|.:.|         .:.||||...|||:.:.|:.....    :.||....:.||..||||:
  Fly  1425 KSMDGSTSGSSVKHHRSRSIVKSASALGLSLMTSLDNSQLAAQLCGIQSPGGGGNGSSTASSRDT 1489

Mouse   966 SPSRDPSPVCGSLRPPIVIHSSGKKYGFSLRAIRVYMGDSDVYTVHHVVWSVEEGSPAQEAGLRA 1030
            ||.|:.||:..:|:|||:|....:.:||::..||||.||:|.||:||:|.:|:|||||.|||||.
  Fly  1490 SPCRELSPLVTNLKPPIIIRRGPRGFGFTVHTIRVYYGDTDFYTMHHLVMAVDEGSPAFEAGLRP 1554

Mouse  1031 GDLITHINGESVLGLVHMDVVELLLKSGNKISLRTTALENTSIKVGPARKNVAKGRMA-----RR 1090
            .|||||:|||:|.||.|..|::|||..|..::||.|.||:|||:.|..::::.:.::|     |:
  Fly  1555 ADLITHVNGEAVQGLFHTQVLQLLLSGGEHVTLRATPLEHTSIQSGGRKRDLMQSKLAKKGVNRQ 1619

Mouse  1091 SKRSRRRETQDRRKSLFKRISK-------------------PS--------SVLHTS--RSFSSG 1126
            .|:::|...:.|:.|||:|||.                   ||        |..|:|  :|.::.
  Fly  1620 KKQTKREHDKKRKTSLFRRISSKRANAEMQQYSAGTSSPTTPSARNLSPLDSSYHSSCCQSAANS 1684

Mouse  1127 LQHSLSSSESLPGSPTHS-------------LSPSPTTPCRSPAPDAPTDTASPPNV------SP 1172
            ...|.|.|.|.|.:||.|             ::||..: .:.|:...||.....|:|      :|
  Fly  1685 SSQSTSPSSSSPNTPTGSSGSNHGGNAGSVAVAPSALS-VQLPSAPPPTQLVLLPHVGAVVGSNP 1748

Mouse  1173 SS--SSPASPATG-----HTRPSSLHGLAAKL----------GPPRHKSG--------------- 1205
            :|  :.|.|| ||     :.|||:||||..||          |...:.:|
  Fly  1749 TSVGNVPVSP-TGVVPQLYQRPSTLHGLKHKLHAATAVIAGGGNANNPAGGLKTLHTTNNNSLPN 1812

Mouse  1206 RRKSTSSIPPSPLACPPVPTP----PPRSPSPLP----GHIP-----IPARSPRLRRGQSADKLG 1257
            ||||...||.||||..|.|:|    |.||||||.    ||.|     ..:.||    |.:...|.
  Fly  1813 RRKSVGHIPLSPLARTPSPSPLPSSPTRSPSPLAFPLVGHQPGASNTTQSYSP----GSTLPTLQ 1873

Mouse  1258 LGTSERLDGDGGRRARGAEAELVVMRRLHLSERRDSFKKQEAVQEVSFDEEP---GPPRGVP--- 1316
            ...:......|..|.:.||....::||. ||.  |....:.|..::|    |   .||...|
  Fly  1874 TAVNANTKKAGFARTKSAEPSSPLLRRA-LSP--DRLHPRSAETKIS----PLCCSPPIKQPTHQ 1931

Mouse  1317 KIAVQGAEATPG 1328
            ::......:|||
  Fly  1932 RVVTTTWRSTPG 1943

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mast3	XP_006509770.2	DUF1908	88..368	CDD:370192	147/360 (41%)
		STKc_MAST	403..682	CDD:270760	206/280 (74%)
		PDZ_signaling	986..1063	CDD:238492	42/76 (55%)
dop	NP_001261884.1	DUF1908	344..702	CDD:286070	147/360 (41%)
		STKc_MAST	834..1115	CDD:270760	206/280 (74%)
		S_TKc	835..1110	CDD:214567	203/274 (74%)
		PDZ_signaling	1506..1587	CDD:238492	44/80 (55%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167844257
Domainoid	1	1.000	440	1.000	Domainoid score	I547
eggNOG	1	0.900	-	-		E1_KOG0606
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	994	1.000	Inparanoid score	I304
Isobase	1	0.950	-	0	Normalized mean entropy	S2004
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D164781at33208
OrthoFinder	1	1.000	-	-		FOG0001156
OrthoInspector	1	1.000	-	-		otm43472
orthoMCL	1	0.900	-	-		OOG6_100724
Panther	1	1.100	-	-	LDO	PTHR24356
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X479
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	14	13.800