DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment ATRX and ISW2

DIOPT Version :9

Sequence 1:NP_000480.3 Gene:ATRX / 546 HGNCID:886 Length:2492 Species:Homo sapiens
Sequence 2:NP_014948.1 Gene:ISW2 / 854480 SGDID:S000005831 Length:1120 Species:Saccharomyces cerevisiae


Alignment Length:1246 Identity:271/1246 - (21%)
Similarity:452/1246 - (36%) Gaps:408/1246 - (32%)


- Green bases have known domain annotations that are detailed below.


Human  1346 TVSDGESGEEKKTKPKEHKEVKGRNRRKVSSEDSE---DSDFQESGVSEEVSESE---DEQRPRT 1404
            |..:.:..:.|.:|.:...||      .|.:.||:   .||....|.|||:|:.|   .|.||  
Yeast     3 TQQEEQRSDTKNSKSESPSEV------LVDTLDSKSNGSSDDDNIGQSEELSDKEIYTVEDRP-- 59

Human  1405 RSAKKAELEENQRSYKQKKKRRRIKVQEDSSSENKSNSEEEEEEKEEEEEEEEEEEEEEEDENDD 1469
                       ...:.|:||:..:.|                          :.:..:::|::|.
Yeast    60 -----------PEYWAQRKKKFVLDV--------------------------DPKYAKQKDKSDT 87

Human  1470 SKS-----------------PGKGRKKIRKILK---DDKLRTETQNALKEEEERRKRIAERERER 1514
            .|.                 ..|..|.|:|:||   .|..:....::......|..|..|:|   
Yeast    88 YKRFKYLLGVTDLFRHFIGIKAKHDKNIQKLLKQLDSDANKLSKSHSTVSSSSRHHRKTEKE--- 149

Human  1515 EKLREVIEIEDASPTKCPITTKLVLDEDEETKEPLVQVHRNMVI-----------KLKPHQVDGV 1568
                     |||         :|:.||:||    :|..::..:.           ||:.:||.|:
Yeast   150 ---------EDA---------ELMADEEEE----IVDTYQEDIFVSESPSFVKSGKLRDYQVQGL 192

Human  1569 QFMWDCCCESVKKTKKSPGSGCILAHCMGLGKTLQVVSFLHTVLLCDKLDFSTALVVCPLNTALN 1633
            .::     .|:.:.|.|.    |||..||||||||.:|||..:....::: ...|::.|.:|..|
Yeast   193 NWL-----ISLHENKLSG----ILADEMGLGKTLQTISFLGYLRYVKQIE-GPFLIIVPKSTLDN 247

Human  1634 WMNEFEKWQEGLK-------DDEKLEVSELATVKRPQERSYMLQ-RWQEDGGVMIIGYEMYRNLA 1690
            |..||.||...:.       .|.:.::          .|:.:|: |:.    |:|..|||   :.
Yeast   248 WRREFLKWTPNVNVLVLHGDKDTRADI----------VRNIILEARFD----VLITSYEM---VI 295

Human  1691 QGRNVKSRKLKEIFNKALVDPGPDFVVCDEGHILKNEASAVSKAMNSIRSRRRIILTGTPLQNNL 1755
            :.:|...|...:            ::|.||.|.:|||.||:|:.:....|:.|:::|||||||||
Yeast   296 REKNALKRLAWQ------------YIVIDEAHRIKNEQSALSQIIRLFYSKNRLLITGTPLQNNL 348

Human  1756 IEYHCMVNFIKENLLGSIKEFRNRFINPIQNGQCADSTMVDVRVMKKRAHILYEMLAGCVQRKDY 1820
            .|...::||:..::.|..:.|...|   .||....|..:|        ...|:.:|...:.|:..
Yeast   349 HELWALLNFLLPDIFGDSELFDEWF---EQNNSEQDQEIV--------IQQLHSVLNPFLLRRVK 402

Human  1821 TALTKFLPPKHEYVLAVRMTSIQCKLYQYYLDHLTGVGNNSEGGR-GKAGAKLFQDFQMLSRIWT 1884
            ..:.|.|.||.|..:.|.||.:|.:.|:..|:......|.:.|.| ||  .:|......|.:...
Yeast   403 ADVEKSLLPKIETNVYVGMTDMQIQWYKSLLEKDIDAVNGAVGKREGK--TRLLNIVMQLRKCCN 465

Human  1885 HPWCLQLDYISKENKGYFDEDSMDEFIASDSDETSMSLSSDDYTKKKKKGKKGKKDSSSSGSGSD 1949
            ||:..:                                                           
Yeast   466 HPYLFE----------------------------------------------------------- 471

Human  1950 NDVEVIKVWNSRSRGGGEGNVDETGNNPSVSLKLEESKATSSSNPSSPAPDWYKDFVTDADAEVL 2014
                           |.|                             |.|.:      ..|..::
Yeast   472 ---------------GAE-----------------------------PGPPY------TTDEHLI 486

Human  2015 EHSGKMVLLFEILRMAEEIGDKVLVFSQSLISLDLIEDFLELASREKTEDKDKPLIYKGEGKWLR 2079
            .:||||::|.::|:..:|.|.:||:|||....||::||:.                      :.|
Yeast   487 FNSGKMIILDKLLKRLKEKGSRVLIFSQMSRLLDILEDYC----------------------YFR 529

Human  2080 NIDYYRLDGSTTAQSRKKWAEEFNDETNVRGRLFIISTKAGSLGINLVAANRVIIFDASWNPSYD 2144
            :.:|.|:||||:.:.|.:..:|:| :.|....:|:::|:||.||||||.|:.||:||:.|||..|
Yeast   530 DFEYCRIDGSTSHEERIEAIDEYN-KPNSEKFVFLLTTRAGGLGINLVTADTVILFDSDWNPQAD 593

Human  2145 IQSIFRVYRFGQTKPVYVYRFLAQGTMEDKIYDRQVTKQSLSFRVVDQQQVERHFTMNELTELYT 2209
            :|::.|.:|.||.|.|:||||:.:..:|:|:.:|...|..|...|:.|.      |..:...|..
Yeast   594 LQAMDRAHRIGQKKQVHVYRFVTENAIEEKVIERAAQKLRLDQLVIQQG------TGKKTASLGN 652

Human  2210 FEPDLLD------DPNSEKKKKRDTPMLPKDTILAE----------------LLQIHK----EHI 2248
            .:.||||      ....|||..:.|.....|.||.:                |..:.|    |:.
Yeast   653 SKDDLLDMIQFGAKNMFEKKASKVTVDADIDDILKKGEQKTQELNAKYQSLGLDDLQKFNGIENQ 717

Human  2249 VGYHEHDSLLDHKEEEELTE------EERKAAWAEYEAE----------KKGLTMRFNIPTGTNL 2297
            ..|..:......|..:::.|      .||:.....|..:          .|..:.:...|.....
Yeast   718 SAYEWNGKSFQKKSNDKVVEWINPSRRERRREQTTYSVDDYYKEIIGGGSKSASKQTPQPKAPRA 782

Human  2298 PPVSFNSQTPYIPFNLGALSA-------------------------------------------- 2318
            |.|.......:.|..|.||..                                            
Yeast   783 PKVIHGQDFQFFPKELDALQEKEQLYFKKKVNYKVTSYDITGDIRNEGSDAEEEEGEYKNAANTE 847

Human  2319 --MSNQQLEDLINQGREKVVEATNSVTAVRIQPLEDIISAVWKENMNLSEAQVQALALSRQASQE 2381
              ..:::|:..|.:.:||:..|.:......::..|.|..|....|.....|.:.|.|...:...|
Yeast   848 GHKGHEELKRRIEEEQEKINSAPDFTQEDELRKQELISKAFTNWNKRDFMAFINACAKYGRDDME 912

Human  2382 -----LDVKRRE--AIYNDVLTKQQMLISCVQRILMNRRLQQQYNQQQQQQMTYQQA-------T 2432
                 :|.|..|  .:|..:..::...|:..::.|.|..|.::.|::.:.|.|..:.       .
Yeast   913 NIKKSIDSKTPEEVEVYAKIFWERLKEINGWEKYLHNVELGEKKNEKLKFQETLLRQKIEQCKHP 977

Human  2433 LGHLMMPKPPN 2443
            |..|::..|||
Yeast   978 LHELIIQYPPN 988

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
ATRXNP_000480.3 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..146
ADDz_ATRX 167..270 CDD:277252
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 445..516
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 535..576
PxVxL motif 581..594
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 593..614
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 649..956
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 968..1479 27/155 (17%)
Interaction with DAXX 1189..1326
SNF2_N 1563..1889 CDD:278600 94/334 (28%)
DEXDc 1588..1750 CDD:238005 48/169 (28%)
DEGH box 1719..1722 2/2 (100%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1913..2000 3/86 (3%)
Interaction with MECP2. /evidence=ECO:0000269|PubMed:17296936 2010..2280 88/301 (29%)
HELICc 2017..2163 CDD:238034 54/145 (37%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 2462..2492
ISW2NP_014948.1 PLN03142 1..1093 CDD:215601 271/1246 (22%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
10.910

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