Protein Alignment ATRX and ISW2

DIOPT Version :10

• Sequence 1: NP_000480.3
• Gene: ATRX / 546
• HGNCID: 886
• Length: 2492
• Species: Homo sapiens
• Sequence 2: NP_014948.1
• Gene: ISW2 / 854480
• SGDID: S000005831
• Length: 1120
• Species: Saccharomyces cerevisiae
• Alignment Length: 1246
• Identity: 271/1246 - (21%)
• Similarity: 452/1246 - (36%)
• Gaps: 408/1246 - (32%)

Human  1346 TVSDGESGEEKKTKPKEHKEVKGRNRRKVSSEDSE---DSDFQESGVSEEVSESE---DEQRPRT 1404
            |..:.:..:.|.:|.:...||      .|.:.||:   .||....|.|||:|:.|   .|.||
Yeast     3 TQQEEQRSDTKNSKSESPSEV------LVDTLDSKSNGSSDDDNIGQSEELSDKEIYTVEDRP-- 59

Human  1405 RSAKKAELEENQRSYKQKKKRRRIKVQEDSSSENKSNSEEEEEEKEEEEEEEEEEEEEEEDENDD 1469
                       ...:.|:||:..:.|                          :.:..:::|::|.
Yeast    60 -----------PEYWAQRKKKFVLDV--------------------------DPKYAKQKDKSDT 87

Human  1470 SKS-----------------PGKGRKKIRKILK---DDKLRTETQNALKEEEERRKRIAERERER 1514
            .|.                 ..|..|.|:|:||   .|..:....::......|..|..|:|
Yeast    88 YKRFKYLLGVTDLFRHFIGIKAKHDKNIQKLLKQLDSDANKLSKSHSTVSSSSRHHRKTEKE--- 149

Human  1515 EKLREVIEIEDASPTKCPITTKLVLDEDEETKEPLVQVHRNMVI-----------KLKPHQVDGV 1568
                     |||         :|:.||:||    :|..::..:.           ||:.:||.|:
Yeast   150 ---------EDA---------ELMADEEEE----IVDTYQEDIFVSESPSFVKSGKLRDYQVQGL 192

Human  1569 QFMWDCCCESVKKTKKSPGSGCILAHCMGLGKTLQVVSFLHTVLLCDKLDFSTALVVCPLNTALN 1633
            .::     .|:.:.|.|.    |||..||||||||.:|||..:....::: ...|::.|.:|..|
Yeast   193 NWL-----ISLHENKLSG----ILADEMGLGKTLQTISFLGYLRYVKQIE-GPFLIIVPKSTLDN 247

Human  1634 WMNEFEKWQEGLK-------DDEKLEVSELATVKRPQERSYMLQ-RWQEDGGVMIIGYEMYRNLA 1690
            |..||.||...:.       .|.:.::          .|:.:|: |:.    |:|..|||   :.
Yeast   248 WRREFLKWTPNVNVLVLHGDKDTRADI----------VRNIILEARFD----VLITSYEM---VI 295

Human  1691 QGRNVKSRKLKEIFNKALVDPGPDFVVCDEGHILKNEASAVSKAMNSIRSRRRIILTGTPLQNNL 1755
            :.:|...|...:            ::|.||.|.:|||.||:|:.:....|:.|:::|||||||||
Yeast   296 REKNALKRLAWQ------------YIVIDEAHRIKNEQSALSQIIRLFYSKNRLLITGTPLQNNL 348

Human  1756 IEYHCMVNFIKENLLGSIKEFRNRFINPIQNGQCADSTMVDVRVMKKRAHILYEMLAGCVQRKDY 1820
            .|...::||:..::.|..:.|...|   .||....|..:|        ...|:.:|...:.|:..
Yeast   349 HELWALLNFLLPDIFGDSELFDEWF---EQNNSEQDQEIV--------IQQLHSVLNPFLLRRVK 402

Human  1821 TALTKFLPPKHEYVLAVRMTSIQCKLYQYYLDHLTGVGNNSEGGR-GKAGAKLFQDFQMLSRIWT 1884
            ..:.|.|.||.|..:.|.||.:|.:.|:..|:......|.:.|.| ||  .:|......|.:...
Yeast   403 ADVEKSLLPKIETNVYVGMTDMQIQWYKSLLEKDIDAVNGAVGKREGK--TRLLNIVMQLRKCCN 465

Human  1885 HPWCLQLDYISKENKGYFDEDSMDEFIASDSDETSMSLSSDDYTKKKKKGKKGKKDSSSSGSGSD 1949
            ||:..:
Yeast   466 HPYLFE----------------------------------------------------------- 471

Human  1950 NDVEVIKVWNSRSRGGGEGNVDETGNNPSVSLKLEESKATSSSNPSSPAPDWYKDFVTDADAEVL 2014
                           |.|                             |.|.:      ..|..::
Yeast   472 ---------------GAE-----------------------------PGPPY------TTDEHLI 486

Human  2015 EHSGKMVLLFEILRMAEEIGDKVLVFSQSLISLDLIEDFLELASREKTEDKDKPLIYKGEGKWLR 2079
            .:||||::|.::|:..:|.|.:||:|||....||::||:.                      :.|
Yeast   487 FNSGKMIILDKLLKRLKEKGSRVLIFSQMSRLLDILEDYC----------------------YFR 529

Human  2080 NIDYYRLDGSTTAQSRKKWAEEFNDETNVRGRLFIISTKAGSLGINLVAANRVIIFDASWNPSYD 2144
            :.:|.|:||||:.:.|.:..:|:| :.|....:|:::|:||.||||||.|:.||:||:.|||..|
Yeast   530 DFEYCRIDGSTSHEERIEAIDEYN-KPNSEKFVFLLTTRAGGLGINLVTADTVILFDSDWNPQAD 593

Human  2145 IQSIFRVYRFGQTKPVYVYRFLAQGTMEDKIYDRQVTKQSLSFRVVDQQQVERHFTMNELTELYT 2209
            :|::.|.:|.||.|.|:||||:.:..:|:|:.:|...|..|...|:.|.      |..:...|..
Yeast   594 LQAMDRAHRIGQKKQVHVYRFVTENAIEEKVIERAAQKLRLDQLVIQQG------TGKKTASLGN 652

Human  2210 FEPDLLD------DPNSEKKKKRDTPMLPKDTILAE----------------LLQIHK----EHI 2248
            .:.||||      ....|||..:.|.....|.||.:                |..:.|    |:.
Yeast   653 SKDDLLDMIQFGAKNMFEKKASKVTVDADIDDILKKGEQKTQELNAKYQSLGLDDLQKFNGIENQ 717

Human  2249 VGYHEHDSLLDHKEEEELTE------EERKAAWAEYEAE----------KKGLTMRFNIPTGTNL 2297
            ..|..:......|..:::.|      .||:.....|..:          .|..:.:...|.....
Yeast   718 SAYEWNGKSFQKKSNDKVVEWINPSRRERRREQTTYSVDDYYKEIIGGGSKSASKQTPQPKAPRA 782

Human  2298 PPVSFNSQTPYIPFNLGALSA-------------------------------------------- 2318
            |.|.......:.|..|.||..
Yeast   783 PKVIHGQDFQFFPKELDALQEKEQLYFKKKVNYKVTSYDITGDIRNEGSDAEEEEGEYKNAANTE 847

Human  2319 --MSNQQLEDLINQGREKVVEATNSVTAVRIQPLEDIISAVWKENMNLSEAQVQALALSRQASQE 2381
              ..:::|:..|.:.:||:..|.:......::..|.|..|....|.....|.:.|.|...:...|
Yeast   848 GHKGHEELKRRIEEEQEKINSAPDFTQEDELRKQELISKAFTNWNKRDFMAFINACAKYGRDDME 912

Human  2382 -----LDVKRRE--AIYNDVLTKQQMLISCVQRILMNRRLQQQYNQQQQQQMTYQQA-------T 2432
                 :|.|..|  .:|..:..::...|:..::.|.|..|.::.|::.:.|.|..:.       .
Yeast   913 NIKKSIDSKTPEEVEVYAKIFWERLKEINGWEKYLHNVELGEKKNEKLKFQETLLRQKIEQCKHP 977

Human  2433 LGHLMMPKPPN 2443
            |..|::..|||
Yeast   978 LHELIIQYPPN 988

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ATRX	NP_000480.3	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..147
		ADDz_ATRX	167..270	CDD:277252
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	445..516
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	535..576
		PxVxL motif	581..594
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	593..616
		PTZ00108	<642..857	CDD:240271
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	649..956
		PTZ00121	<791..1438	CDD:173412	23/97 (24%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	968..1479		27/155 (17%)
		Interaction with DAXX	1189..1326
		HepA	<1543..2191	CDD:440319	168/667 (25%)
		DEXHc_ATRX	1560..1803	CDD:350826	72/250 (29%)
		DEGH box	1719..1722		2/2 (100%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1913..2000		3/86 (3%)
		Interaction with MECP2. /evidence=ECO:0000269|PubMed:17296936	2010..2280		88/301 (29%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	2462..2492
ISW2	NP_014948.1	PLN03142	1..1093	CDD:215601	271/1246 (22%)