DRSC/TRiP Functional Genomics Resources

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Protein Alignment ATRX and RAD26

DIOPT Version :10

Sequence 1:NP_000480.3 Gene:ATRX / 546 HGNCID:886 Length:2492 Species:Homo sapiens
Sequence 2:NP_012569.1 Gene:RAD26 / 853492 SGDID:S000003796 Length:1085 Species:Saccharomyces cerevisiae


Alignment Length:1407 Identity:313/1407 - (22%)
Similarity:533/1407 - (37%) Gaps:468/1407 - (33%)


- Green bases have known domain annotations that are detailed below.


Human  1102 RKRQDCSSSDTEKYSMKEDGCNSSDKRLKRIELRER--RNLSSKRNTKEIQSGSSSSDAEESSED 1164
            :::||.:..:..: |:|:.|.|.    |.:..|.|:  .::::..|.:.:|      ..|...|.
Yeast     4 KEQQDNAKLENNE-SLKDLGVNV----LSQSSLEEKIANDVTNFSNLQSLQ------QEETRLER 57

Human  1165 NKKKKQRTSSKKKAVIVKEKKRNSLRTSTKRKQAD-ITSSSSSDIEDDDQNSIGEGSSDEQKIKP 1228
            :|...||..:||..  :..|..|:.|.|.|:...| |.:..|.|||                   
Yeast    58 SKTALQRYVNKKNH--LTRKLNNTTRISVKQNLRDQIKNLQSDDIE------------------- 101

Human  1229 VTENLVLSSHTGFCQSSGDEALSKSVPVTVDDDDDDNDPENRIAKKMLLEEIKANLSSDEDGSSD 1293
                .||.                          |.:|.::||  |.|.|::       :.|:.:
Yeast   102 ----RVLK--------------------------DIDDIQSRI--KELKEQV-------DQGAEN 127

Human  1294 DEPEEGKKRTGKQNEENPGDEEAKNQVNSESDSDSEESKKPRYRHRLLR-HKLTVSDGESGEEKK 1357
            ...:||.:|        ||:.|                     :..|:| .|:|....::|....
Yeast   128 KGSKEGLQR--------PGETE---------------------KEFLIRTGKITAFGHKAGFSLD 163

Human  1358 TKPKEHKEVKGRNRRKVSSEDSEDSDFQESGVSEEVSESEDEQRPRTRSAKKAELEENQRSYKQK 1422
            |          .||....:::.:|.|| |....:.|....||                       
Yeast   164 T----------ANREYAKNDEQKDEDF-EMATEQMVENLTDE----------------------- 194

Human  1423 KKRRRIKVQEDSSSENKSNSEEEEEEKEEEEEEEEEEEEEEEDENDDSKSPGKGRKKIRKILKDD 1487
                         .:|.|:.:.:...||.|::|||        ||||         ||.|.|:|.
Yeast   195 -------------DDNLSDQDYQMSGKESEDDEEE--------ENDD---------KILKELEDL 229

Human  1488 KLRTETQNA------LKEEEERRKRIAEREREREKLREVIEIEDASPTKCPITTKLVLDEDEETK 1546
            :.|.:...|      |..:|..:|.:.:|....::..::.|.....|.                 
Yeast   230 RFRGQPGEAKDDGDELYYQERLKKWVKQRSCGSQRSSDLPEWRRPHPN----------------- 277

Human  1547 EPLVQVHRNMVIKLKPHQVDGVQFMWDCCCESVKKTKKSPGSGCILAHCMGLGKTLQVVSFL--- 1608
              :.....|...|: |.::..:.|.:...|............|.|:...||||||:||::|:   
Yeast   278 --IPDAKLNSQFKI-PGEIYSLLFNYQKTCVQWLYELYQQNCGGIIGDEMGLGKTIQVIAFIAAL 339

Human  1609 -HTVLLCDKLDFSTALVVCPLNTALNWMNEFEKW------------QEGLKDDEKLEVSE----- 1655
             |:.||.     ...|:|||......|.|||:.|            ..|:..|:|.::.|     
Yeast   340 HHSGLLT-----GPVLIVCPATVMKQWCNEFQHWWPPLRTVILHSMGSGMASDQKFKMDENDLEN 399

Human  1656 LATVKRPQERSYMLQRWQE-----------------------DGGVMIIGYEMYRNLAQGRNVKS 1697
            |....:|.:.||  :.|:.                       ||.::|..|       .|..:.|
Yeast   400 LIMNSKPSDFSY--EDWKNSTRTKKALESSYHLDKLIDKVVTDGHILITTY-------VGLRIHS 455

Human  1698 RKLKEIFNKALVDPGPDFVVCDEGHILKNEASAVSKAMNSIRSRRRIILTGTPLQNNLIEYHCMV 1762
            .||.::        ...:.|.||||.::|..|.:|.....:::..||||:|||:||||.|...:.
Yeast   456 DKLLKV--------KWQYAVLDEGHKIRNPDSEISLTCKKLKTHNRIILSGTPIQNNLTELWSLF 512

Human  1763 NFIKENLLGSIKEFRNRFINPIQNGQCADSTMVDVRVMKKRAHILYEMLAGCVQRKDYTALTKFL 1827
            :||....||::..|:.:|:.||..|..|::|.:.|:...|.|..|.::::..:.|:....:.|.|
Yeast   513 DFIFPGKLGTLPVFQQQFVIPINIGGYANATNIQVQTGYKCAVALRDLISPYLLRRVKADVAKDL 577

Human  1828 PPKHEYVLAVRMTSIQCKLYQYYLDHLTGVGNNSEGGRGKAGAKLFQDFQMLSRIWTHPWCLQLD 1892
            |.|.|.||..::|..|...|..:| |.:.:.....|.|.    .|| ...:|.:|..||     |
Yeast   578 PQKKEMVLFCKLTKYQRSKYLEFL-HSSDLNQIQNGKRN----VLF-GIDILRKICNHP-----D 631

Human  1893 YISKENKGYFDEDSMDEFIASDSDETSMSLSSDDYTKKKKKGKKGKKDSSSSGSGSDNDVEVIKV 1957
            .:.::.|.:                      :.||...|:                         
Yeast   632 LLDRDTKRH----------------------NPDYGDPKR------------------------- 649

Human  1958 WNSRSRGGGEGNVDETGNNPSVSLKLEESKATSSSNPSSPAPDWYKDFVTDADAEVLEHSGKMVL 2022
                                                                       ||||.:
Yeast   650 -----------------------------------------------------------SGKMQV 655

Human  2023 LFEILRMAEEIGDKVLVFSQSLISLDLIEDFLELASREKTEDKDKPLIYKGEGKWLRNIDYYRLD 2087
            :.::|.:..:.|.|.|:|:||...||::|:|:      .|:|.|           |.:::|.|:|
Yeast   656 VKQLLLLWHKQGYKALLFTQSRQMLDILEEFI------STKDPD-----------LSHLNYLRMD 703

Human  2088 GSTTAQSRKKWAEEFNDETNVRGRLFIISTKAGSLGINLVAANRVIIFDASWNPSYDIQSIFRVY 2152
            |:|..:.|:...:.||:|:   ..:|:::|:.|.||:||..|||:||||..||||.|:|:..|.:
Yeast   704 GTTNIKGRQSLVDRFNNES---FDVFLLTTRVGGLGVNLTGANRIIIFDPDWNPSTDMQARERAW 765

Human  2153 RFGQTKPVYVYRFLAQGTMEDKIYDRQVTKQSLSFRVVDQQQVERHFTMNELTELYTFEPD---L 2214
            |.||.:.|.:||.:..|::|:|||.||:.||.|:.|::...:.:|.|.::||.:|::...:   .
Yeast   766 RIGQKREVSIYRLMVGGSIEEKIYHRQIFKQFLTNRILTDPKQKRFFKIHELHDLFSLGGENGYS 830

Human  2215 LDDPNSEKKKKRDTPMLPKDTILAELLQIHKEHIVGYHEHDSLLDHKEEEE--LTEEERKAAWAE 2277
            .::.|.|.:|..:.....|.....:..|:  .::.|..:.:|..:.||::|  .||::|..    
Yeast   831 TEELNEEVQKHTENLKNSKSEESDDFEQL--VNLSGVSKLESFYNGKEKKENSKTEDDRLI---- 889

Human  2278 YEAEKKGLTMRFNIPTGTNLPPVSFNSQTPYIPFNLGALSAMSNQQLEDLINQGREKV-VEATNS 2341
                 :||     :...:||..|..:...    .|..|.|:.||     :|.:...:| :||.|:
Yeast   890 -----EGL-----LGGESNLETVMSHDSV----VNSHAGSSSSN-----IITKEASRVAIEAVNA 935

Human  2342 VTAVR--IQPLEDIISAVW----------------KENM--------NLSEAQVQALALSRQASQ 2380
            :...|  |....:|.:..|                |..:        |::::|.:|   |::|.|
Yeast   936 LRKSRKKITKQYEIGTPTWTGRFGKAGKIRKRDPLKNKLTGSAAILGNITKSQKEA---SKEARQ 997

Human  2381 ELDVKRREAIYNDVLT-KQQMLISCVQRILMNRR--LQQQYN 2419
            |        .|:|.:| .:...|:...:.|.|.|  ||:|.|
Yeast   998 E--------NYDDGITFARSKEINSNTKTLENIRAYLQKQNN 1031

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
ATRXNP_000480.3 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..147
ADDz_ATRX 167..270 CDD:277252
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 445..516
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 535..576
PxVxL motif 581..594
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 593..616
PTZ00108 <642..857 CDD:240271
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 649..956
PTZ00121 <791..1438 CDD:173412 60/339 (18%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 968..1479 72/380 (19%)
Interaction with DAXX 1189..1326 25/137 (18%)
HepA <1543..2191 CDD:440319 172/691 (25%)
DEXHc_ATRX 1560..1803 CDD:350826 75/286 (26%)
DEGH box 1719..1722 2/2 (100%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1913..2000 3/86 (3%)
Interaction with MECP2. /evidence=ECO:0000269|PubMed:17296936 2010..2280 84/274 (31%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 2462..2492
RAD26NP_012569.1 HepA <222..792 CDD:440319 178/748 (24%)
CSB_WHD 1019..1080 CDD:439329 7/13 (54%)
Blue background indicates that the domain is not in the aligned region.

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