Protein Alignment ATRX and atrx

DIOPT Version :9

• Sequence 1: NP_000480.3
• Gene: ATRX / 546
• HGNCID: 886
• Length: 2492
• Species: Homo sapiens
• Sequence 2: XP_021336651.1
• Gene: atrx / 323299
• ZFINID: ZDB-GENE-030912-11
• Length: 2053
• Species: Danio rerio
• Alignment Length: 2551
• Identity: 1271/2551 - (49%)
• Similarity: 1569/2551 - (61%)
• Gaps: 561/2551 - (21%)

Human     1 MTAEPMSESKLNTLVQKLHDFLAHSSEESEETSSPPRLAMNQNTDKISGSGSNSDMM---ENSKE 62
            ||.:....|||||||.|||:||.||          |.:....:.|..||..:.:|:.   |...|
Zfish     1 MTTDICRSSKLNTLVTKLHEFLGHS----------PDIESIDSQDISSGKMATNDVNIADEKMNE 55

Human    63 EGTSSSEKSKSSGSSRSKRKPSIVTKYVESDDEKPLDDETVNEDASNENSENDITMQSLPKGTVI 127
            .| .|||.:|.| |||||||||.|||:. :.||....:|:..|..::::.::.:.:..||:|||:
Zfish    56 PG-CSSEITKPS-SSRSKRKPSFVTKHT-ALDESECANESGGEPCADDSMQSSLDISKLPQGTVV 117

Human   128 VQPEPVLNEDKDDFKGPEFRSR-SKMKTENLKKRGEDGLHGIVSCTACGQQVNHFQKDSIYRHPS 191
            |:||||.||.||:|:|||||:: .|.|.|..:||.:|.|..|.:||||||||||||||||::||:
Zfish   118 VKPEPVANETKDEFRGPEFRNKGGKAKEEGARKRPDDQLQEIFNCTACGQQVNHFQKDSIFQHPA 182

Human   192 LQVLICKNCFKYYMSDDISRDSDGMDEQCRWCAEGGNLICCDFCHNAFCKKCILRNLGRKELSTI 256
            |.|||||:|||||||||||:|.:|||||||||||||||:|||:|.||||||||||||||||||.|
Zfish   183 LHVLICKSCFKYYMSDDISKDDEGMDEQCRWCAEGGNLMCCDYCSNAFCKKCILRNLGRKELSEI 247

Human   257 MDENNQWYCYICHPEPLLDLVTACNSVFENLEQLLQQNKKKIKVDSEKS---NKVYEHTSRFSPK 318
            |.|.::|:||||.||||.|.|..|..|..|||    .:.:|.|.:.:|:   .:.::|..|   :
Zfish   248 MSEQSKWHCYICCPEPLQDHVKTCEKVLLNLE----SSSRKPKGEHDKTKREERKHKHVKR---E 305

Human   319 KTSSNCNGEEKKLDDSCSGSVTYSYSALIVPKEMIKKAKKLIETTANMNSSYVKFLKQATDNSEI 383
            ||:  .||::...|.  :|::|:|...|.||||::||.|||||||..:|.::|:||:|.:...|
Zfish   306 KTA--VNGQDYASDG--AGTLTFSCKTLTVPKELVKKTKKLIETTNGLNRTFVQFLQQTSKGQE- 365

Human   384 SSATKLRQLKAFKSVLADIKKAHLALEEDLNSEF--RAMDAVNKEK------NTKEHKVIDAKF- 439
            :||...|.||||||||||:||||.||||.|.:||  :.:...|.|:      .:.|:.|:::..
Zfish   366 ASAVSYRHLKAFKSVLADLKKAHAALEESLENEFESKGLKFQNGEEQRPSNSQSVENAVVNSNHT 430

Human   440 -ETKARKGEKPCALEK-----KDISKSEAKLSRKQVDS------EHMHQNVPTEEQRTNKSTGGE 492
             .|..::.:..|:.:.     ::.::.::.|:..:::|      :...|:....|::.|:.....
Zfish   431 EPTPVKEDDLDCSTKNHNPVGEEETQQDSNLADVEMESPPHSPEKAQEQSEERSEEKENEEKENG 495

Human   493 HKKSDRK--------EEPQYEPANTSEDLDMDIVSVPSSVPEDIFENLET-AMEVQSSVDHQGDG 548
            .|:::.|        ||....||  .|.||.||||:|.||||::||.:|: |::.:::.|:..|.
Zfish   496 EKENEAKEQEIADNFEEGSVPPA--EESLDKDIVSIPPSVPEELFEMVESLAVKKENNDDNLTDS 558

Human   549 SSGTEQEVESSSVKLNISSKDNRGGIKS-KTTAKVTKELYVKLTPVSLSNSPIKGADCQEVPQDK 612
            |                .:|.|...::| |:..|:.|:|.||||||.|..:         :.:||
Zfish   559 S----------------DNKSNTEVVESKKSLTKLGKKLVVKLTPVPLKIT---------IKRDK 598

Human   613 DGYKSCGLNPKLEKCGLGQENSDNEHLVENEVSLLLEESDLRRSPRVKTTPLRRPTETNPVTSNS 677
            ...:|            ..|:.|.|.|.:.:        |.|||||:||||||:..|
Zfish   599 SREQS------------PSEDMDGEALKDGQ--------DSRRSPRMKTTPLRKSPE-------- 635

Human   678 DEECNETVKEKQKLSVPVRKKDKRNSSDSAIDNPKPNKLPKSKQSETVDQNSDSDEMLAILKEVS 742
                   .|.|:||:  :.|.|:: |||:.           .:||:     |||||:..:|:..:
Zfish   636 -------AKSKRKLN--MSKADEK-SSDAV-----------KEQSD-----SDSDEVPEVLQSAA 674

Human   743 RMSHSSSSDTDINEIHTNHKTLYDLKTQAGKDDKGKRKRKSSTSGSDFDTKKGKSAKSSIISKKK 807
            ....|..|:.:    :|:.|.....:..:....|.|.|||.....|:.|..:..||.....:|||
Zfish   675 LKDSSDESEPE----NTSPKRTKKRRLSSRSTAKPKTKRKLEEGSSESDDSEKPSAAKKRSAKKK 735

Human   808 RQTQSESSNYDSELEKEIKSMSKIGAARTTKKRIPNTKDFDSSEDEKHSKKGMDNQGHKNLKTSQ 872
            :..:|:|||::|:||||||.:||:.
Zfish   736 KGKESDSSNHNSDLEKEIKKLSKVD---------------------------------------- 760

Human   873 EGSSDDAERKQERETFSSAEGTVDKDTTIMELRDRLPKKQQASASTDGVDKLSGKEESFTSLEVR 937
                                                                |||::|
Zfish   761 ----------------------------------------------------SGKKKS------- 766

Human   938 KVAETKEKSKHLKTKTCKKVQDGLSDIAEKFLKKDQSDETSEDDKKQSKKGTEEKKKPSDFKKKV 1002
                                         |..|||: ||.|::.||..|:..|
Zfish   767 -----------------------------KSTKKDE-DEGSKEVKKGPKRSFE------------ 789

Human  1003 IKMEQQYESSSDGTEKLPEREEICHFPKGIKQIKNGTTDGEKKSKKIRDKTSKKKDELSDYAEKS 1067
                                                                             
Zfish   790 ----------------------------------------------------------------- 789

Human  1068 TGKGDSCDSSEDKKSKNGAYGREKKRCKLLGKSSRKRQDCSSSDTEKYSMKEDGCNSSDKRLKRI 1132
                                                                             
Zfish   790 ----------------------------------------------------------------- 789

Human  1133 ELRERRNLSSKRNTKEIQSGSSSSDAEESSEDNKKKKQRTSSKKKAVIVKEKKRNSLRTSTKRKQ 1197
              |:||:...|..|||   .|||||.||..|                                ||
Zfish   790 --RKRRSQREKAKTKE---ESSSSDEEEEEE--------------------------------KQ 817

Human  1198 ADITSSSSSDIEDDDQNSIGEGSSDEQKIKPVTENLVLSSHTGFCQSSGDEALSKSVPVTVDDDD 1262
            ||              || || .||:|||||:.|: |::|..||.||||||...|:....|.|||
Zfish   818 AD--------------NS-GE-DSDQQKIKPILES-VIASIDGFHQSSGDEVELKNEASQVVDDD 865

Human  1263 DDNDPENRIAKKMLLEEIKANLSSDEDGSSDDE---PEEG-----KKRTGKQNEENPGDEEAKNQ 1319
            |  ||||||||:|||.:||||.||..|.|||||   .|:|     :|...|:.:|:..|||
Zfish   866 D--DPENRIAKRMLLAQIKANYSSGADSSSDDENADKEDGDSTKKEKDNAKKEDESDSDEE---- 924

Human  1320 VNSESDSDSE-ESKKPRYRHRLLRHKLTVSDGESGEEKKTKPKEHKEVKGRNRRKVSSEDSEDSD 1383
              :.|||.|: :.||...||||||.||::|:|||.||...|.|  ||.|.|.||||.|:||.|||
Zfish   925 --TTSDSGSDVDLKKGGRRHRLLRKKLSLSEGESDEENAVKNK--KETKKRGRRKVDSDDSADSD 985

Human  1384 FQE--------SGVSEEVSESEDEQRP---RTRSAKKAELEENQRSY-KQKKKRRRIKVQEDSSS 1436
            |:.        |.:||.|||.||:::.   :|||:||| .::.:||| |:||||||||||| |||
Zfish   986 FKHSRSDSSDASALSEAVSEDEDDEKSTKRKTRSSKKA-AKDKERSYKKEKKKRRRIKVQE-SSS 1048

Human  1437 ENKSNSEEEEEEKEEEEEEEEEEEEEEEDENDDSKSPGKGRKKIRKILKDDKLRTETQNALKEEE 1501
            ..||.                 |||.||.:.||..:| |||||||||:|||||||||::||||||
Zfish  1049 SGKSG-----------------EEEGEEGDEDDKGTP-KGRKKIRKIIKDDKLRTETRDALKEEE 1095

Human  1502 ERRKRIAEREREREKLREVIEIEDASPTKCPITTKLVLDEDEETKEPLVQVHRNMVIKLKPHQVD 1566
            :||||||||||.||||||.||::::|...|||||||||||||||||||||||||||.||||||||
Zfish  1096 DRRKRIAERERLREKLRETIEVKESSQVTCPITTKLVLDEDEETKEPLVQVHRNMVTKLKPHQVD 1160

Human  1567 GVQFMWDCCCESVKKTKKSPGSGCILAHCMGLGKTLQVVSFLHTVLLCDKLDFSTALVVCPLNTA 1631
            |||||||||||||:|.:||.|||||||||||||||||||:.|||||||:||:||||||||||||.
Zfish  1161 GVQFMWDCCCESVRKVEKSAGSGCILAHCMGLGKTLQVVTLLHTVLLCEKLNFSTALVVCPLNTV 1225

Human  1632 LNWMNEFEKWQEGLKDDEKLEVSELATVKRPQERSYMLQRWQEDGGVMIIGYEMYRNLAQGRNVK 1696
            |||:||||||||||||:|.|||:|||||||||||:|.||||||||||||:||||||||.||||:|
Zfish  1226 LNWLNEFEKWQEGLKDEESLEVTELATVKRPQERAYALQRWQEDGGVMIMGYEMYRNLTQGRNIK 1290

Human  1697 SRKLKEIFNKALVDPGPDFVVCDEGHILKNEASAVSKAMNSIRSRRRIILTGTPLQNNLIEYHCM 1761
            |:||||.|.|.|||||||||:|||||:|||||||||||||||::|||::||||||||||||||||
Zfish  1291 SKKLKETFQKTLVDPGPDFVICDEGHVLKNEASAVSKAMNSIKTRRRVVLTGTPLQNNLIEYHCM 1355

Human  1762 VNFIKENLLGSIKEFRNRFINPIQNGQCADSTMVDVRVMKKRAHILYEMLAGCVQRKDYTALTKF 1826
            |||||||||||:||||||||||||||||||||:|||||||||||||||||||||||:||||||||
Zfish  1356 VNFIKENLLGSVKEFRNRFINPIQNGQCADSTLVDVRVMKKRAHILYEMLAGCVQRRDYTALTKF 1420

Human  1827 LPPKHEYVLAVRMTSIQCKLYQYYLDHLTGVGNNSEGGRGKAGAKLFQDFQMLSRIWTHPWCLQL 1891
            ||||||||||||::.||||||:|||||.||||:..|.|:|:||.|||||||||||||||||||||
Zfish  1421 LPPKHEYVLAVRLSPIQCKLYRYYLDHFTGVGSALESGKGRAGTKLFQDFQMLSRIWTHPWCLQL 1485

Human  1892 DYISKENKGYFDEDSMDEFIASDSDETSMSLSSDDYTKKKKKGKKGK-KDSSSSGSGSDNDVEVI 1955
            ||||||||||||||||:|||||:::|:||||:|:| .|.|:|.|:|: ||.||..|.|| |:|||
Zfish  1486 DYISKENKGYFDEDSMEEFIASETEESSMSLTSED-EKPKRKKKRGRGKDQSSDKSDSD-DLEVI 1548

Human  1956 KVWNSRSRGGGEGNVDETGNNPSVSLKLE--ESKATSSSNPSSPAPDWYKDFVTDADAEVLEHSG 2018
            |.||:.||||          ||....:.|  |....|:|.|.||:|:|||:||::.|||||.|||
Zfish  1549 KEWNTSSRGG----------NPEGRNRAEPVEEVRPSNSGPGSPSPEWYKEFVSEEDAEVLTHSG 1603

Human  2019 KMVLLFEILRMAEEIGDKVLVFSQSLISLDLIEDFLELASREKTEDKDKPLIYKGEGKWLRNIDY 2083
            ||||||||||:|||:.|||||||||||||||||||||||.|.|.|.|:.|  |||||||.|||||
Zfish  1604 KMVLLFEILRLAEEVDDKVLVFSQSLISLDLIEDFLELAGRAKEEGKESP--YKGEGKWFRNIDY 1666

Human  2084 YRLDGSTTAQSRKKWAEEFNDETNVRGRLFIISTKAGSLGINLVAANRVIIFDASWNPSYDIQSI 2148
            |||||||.|.:||||||:|||.:|||||||:|||:||||||||||||||||||||||||||||||
Zfish  1667 YRLDGSTNALTRKKWAEDFNDISNVRGRLFLISTRAGSLGINLVAANRVIIFDASWNPSYDIQSI 1731

Human  2149 FRVYRFGQTKPVYVYRFLAQGTMEDKIYDRQVTKQSLSFRVVDQQQVERHFTMNELTELYTFEPD 2213
            ||||||||.|.|||||||||||||:|||||||.|||||||||||||:||||||||||||||||||
Zfish  1732 FRVYRFGQVKTVYVYRFLAQGTMEEKIYDRQVAKQSLSFRVVDQQQIERHFTMNELTELYTFEPD 1796

Human  2214 LLDDPNSEKKKKRDTPMLPKDTILAELLQIHKEHIVGYHEHDSLLDHKEEEELTEEERKAAWAEY 2278
            .|||| ||||.||.|||||||.:|||||..:|:|||.||||||||||||||.|:||:||||||||
Zfish  1797 QLDDP-SEKKSKRATPMLPKDPVLAELLHSYKDHIVCYHEHDSLLDHKEEEALSEEDRKAAWAEY 1860

Human  2279 EAEKKGLTMRFNIPTGTNLPPVSFNSQTPYIPFNLGALSAMSNQQLEDLINQGREKVVEATNSVT 2343
            |||||||:||||.|:.:.:...:.||   |.|||:.||::||||||||||||||:||:||::::.
Zfish  1861 EAEKKGLSMRFNQPSYSQMGMGAPNS---YFPFNVAALASMSNQQLEDLINQGRQKVLEASSALK 1922

Human  2344 AVRIQPLEDIISAVWKENMNLSEAQVQALALSRQASQELDVKRREAIYNDVLTKQQMLISCVQRI 2408
            .|..:.||||::.|||||.:|.||||.::||.|||..||:||.|||||.|||:|||.|:..||::
Zfish  1923 TVPREALEDIVAQVWKENPSLPEAQVHSMALGRQAGFELEVKHREAIYRDVLSKQQTLMMYVQKV 1987

Human  2409 LMNRRLQQQYNQQQQQQMTYQQATLGHLMMPKPPNLIMNPSNYQQIDMRGMYQPVAGGMQPPPLQ 2473
            |.||::     |:||..|..|...|..|.|   .|.:..|.|  |:|:.|:||.:..      ||
Zfish  1988 LANRKV-----QEQQLAMARQGMLLNQLAM---QNGLTGPMN--QMDLLGLYQQLGA------LQ 2036

Human  2474 RAPPPMRSKNPGPSQG 2489
            ..|.|...||||||:|
Zfish  2037 GLPTPQLGKNPGPSKG 2052

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ATRX	NP_000480.3	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..146		62/147 (42%)
		ADDz_ATRX	167..270	CDD:277252	82/102 (80%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	445..516		15/89 (17%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	535..576		6/40 (15%)
		PxVxL motif	581..594		8/12 (67%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	593..614		4/20 (20%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	649..956		63/306 (21%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	968..1479		170/531 (32%)
		Interaction with DAXX	1189..1326		64/144 (44%)
		SNF2_N	1563..1889	CDD:278600	282/325 (87%)
		DEXDc	1588..1750	CDD:238005	137/161 (85%)
		DEGH box	1719..1722		2/2 (100%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1913..2000		40/89 (45%)
		Interaction with MECP2. /evidence=ECO:0000269|PubMed:17296936	2010..2280		229/269 (85%)
		HELICc	2017..2163	CDD:238034	123/145 (85%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	2462..2492		11/28 (39%)
atrx	XP_021336651.1	ADDz_ATRX	158..261	CDD:277252	82/102 (80%)
		Neuromodulin_N	<594..1151	CDD:331332	306/969 (32%)
		SNF2_N	1157..1483	CDD:306645	282/325 (87%)
		HELICc	1602..1746	CDD:238034	123/145 (85%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C194332680
Domainoid	1	1.000	597	1.000	Domainoid score	I1753
eggNOG	1	0.900	-	-		E2759_KOG1015
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H416
Inparanoid	1	1.050	1748	1.000	Inparanoid score	I638
NCBI	1	1.000	-	-
OMA	1	1.010	-	-		QHG39559
OrthoDB	1	1.010	-	-		D111318at33208
OrthoFinder	1	1.000	-	-		FOG0003310
OrthoInspector	1	1.000	-	-		oto50791
orthoMCL	1	0.900	-	-		OOG6_104269
Panther	1	1.100	-	-	LDO	PTHR46357
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4866
SonicParanoid	1	1.000	-	-		X2684
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
ZFIN	1	1.500	-	-
	19	19.300