DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ATRX and atrx

DIOPT Version :9

Sequence 1:	NP_000480.3	Gene:	ATRX / 546	HGNCID:	886	Length:	2492	Species:	Homo sapiens
Sequence 2:	XP_002931858.1	Gene:	atrx / 100380046	XenbaseID:	XB-GENE-980568	Length:	2268	Species:	Xenopus tropicalis

Alignment Length:	2671	Identity:	1504/2671 - (56%)
Similarity:	1760/2671 - (65%)	Gaps:	582/2671 - (21%)

- Green bases have known domain annotations that are detailed below.

Human     1 MTAEPMSESKLNTLVQKLHDFLAHSSEESEETSSPPRLAMNQNTDKISGSGSNSDMMENSKEEGT 65
            |||||||||||||||:||||||||||||||:|:||.|.:::::..|:. |......|||:.:||
Frog     1 MTAEPMSESKLNTLVKKLHDFLAHSSEESEDTTSPTRQSVSRSAAKVK-SVHRLHPMENNMDEG- 63

Human    66 SSSEKSKSSGSSRSKRKPSIVTKYVESDDEKPLDDETVNEDASNENSENDITMQSLPKGTVIVQP 130
            |:|||.||.||||||||||.|.|||.||:| .:.||.||.|.|||||||::.|:|||.|||:|||
Frog    64 STSEKLKSLGSSRSKRKPSFVQKYVGSDEE-TVPDEVVNLDGSNENSENEVDMESLPIGTVVVQP 127

Human   131 EPVLNEDKDDFKGPEFRSRSKMKTENL--KKRGEDGLHGIVSCTACGQQVNHFQKDSIYRHPSLQ 193
            |||||||||||||||||||:|.|.:..  |||.||||||||:||||||||||||||||||||:|:
Frog   128 EPVLNEDKDDFKGPEFRSRNKPKPDITIPKKRTEDGLHGIVNCTACGQQVNHFQKDSIYRHPALK 192

Human   194 VLICKNCFKYYMSDDISRDSDGMDEQCRWCAEGGNLICCDFCHNAFCKKCILRNLGRKELSTIMD 258
            |||||.|:||||||||:||:||||||||||||||||||||:||||||||||||||||||||.|||
Frog   193 VLICKACYKYYMSDDINRDADGMDEQCRWCAEGGNLICCDYCHNAFCKKCILRNLGRKELSAIMD 257

Human   259 ENNQWYCYICHPEPLLDLVTACNSVFENLEQLLQQNKKKIKVDSEKSNKVYEHTSRFSPKKTSSN 323
            |..:|.||||.||||||.||||:||||||||||||||||:|.|:|| ||..||:...|.|:.||
Frog   258 EEMKWECYICRPEPLLDSVTACDSVFENLEQLLQQNKKKMKSDNEK-NKSNEHSQNDSDKRNSS- 320

Human   324 CNGEEKKLDDSCSGSVTYSYSALIVPKEMIKKAKKLIETTANMNSSYVKFLKQATDNSEISSATK 388
            .||:.|.:.|:.:|::||||.||:|||||:||||||||||.::|:|:|||:||.|.|:|::.|.|
Frog   321 YNGQGKNVGDAHAGTLTYSYRALMVPKEMLKKAKKLIETTTSLNASFVKFMKQGTANNELNPAEK 385

Human   389 LRQLKAFKSVLADIKKAHLALEEDLNSEFRAMDAVNKEKNTKE---------------------- 431
            |||||||||||.|:||||.||||.|..|..::|...|.|.:||
Frog   386 LRQLKAFKSVLGDLKKAHEALEETLMEEIHSVDEQKKSKKSKETTSENKHAKEKKLGEEKQKEPK 450

Human   432 -----HKVIDAKFETKARKGEK-------------------------------PCA--------- 451
                 .|...:..:.|.|..:|                               ||:
Frog   451 KIVAREKAKPSDSDNKQRDCDKNASNDTEQAEEALIQNGKNVDLTEEDTIKSEPCSAAADVTEVL 515

Human   452 ---LEKKDIS----------------------------KSEAKLS---------------RKQVD 470
               .|..|||                            ||:.|..               :|.||
Frog   516 ATDAEGTDISVVMEEADENVDGKNEKATVESDDNEGKQKSQKKKQKSMHDKPRENSPGNRKKSVD 580

Human   471 S-----EHMHQNVPTEEQRTNKSTGGEHKKSDRKEEPQ---------YEPANTSEDLDMDIVSVP 521
            |     |.:......|::|.::.|  |..||.:...||         :|| |::|.|||||||||
Frog   581 SPKKERESVLPEKTKEKKRADQCT--ESSKSGKSRTPQKKSKNAEATFEP-NSTEALDMDIVSVP 642

Human   522 SSVPEDIFENLETAMEVQSSVDHQGDGSSGTEQEVESSSVKLNISSKDNRGGIKSKTTAK--VTK 584
            ||||||||::|:.::|.|:|:          :..|.|::|...          |.|...|  |.|
Frog   643 SSVPEDIFDSLDASLEQQNSL----------QDSVTSTAVSTP----------KCKEELKPLVKK 687

Human   585 ELYVKLTPVSLSNSPIKGADCQEVPQDKDGYKSCGLNPK------LEKCGLGQENSDNEHLVENE 643
            :|.|:||||||||||:| ||.          .|.|.:||      .|.....|.::..:.::||.
Frog   688 QLIVQLTPVSLSNSPVK-ADS----------NSAGKSPKADIGSDAETEAQNQNSASCDEVLENS 741

Human   644 VSLLLEESDLRRSPRVKTTPLRRPTETNPVTSNSDEECNETVKEKQKLSVPVRKKDKRNS----- 703
            ....||||.|||||||||||.||.|:.|...||::||.|:|.||| |.......|:||||
Frog   742 SENDLEESALRRSPRVKTTPRRRQTDANSAASNTEEESNDTDKEK-KSKRAACSKEKRNSTAKHS 805

Human   704 -SDSAIDNPKPNK-LPKSKQSETVDQNSDSDEMLAILKEVSRMSHSSSSDTDINEIHTNHKTLYD 766
             ::|. ::||..: |.|..|::.....|||||:..:||:.:.||:|||.....||.::..:|
Frog   806 PAESG-ESPKAKRSLAKKMQAQVNKSTSDSDEVPEVLKKAALMSNSSSELDSSNEANSGKRT--- 866

Human   767 LKTQAGKDDKG--KRKRKSSTSGSDFDTKKGKSAKSSIISKKKRQTQSESSNYDSELEKEIKSMS 829
             ..:..|..||  ||||.||:|||:   ...::.::|..:||||..||::||  ||||||:|.:.
Frog   867 -SNRQDKTAKGYSKRKRSSSSSGSE---PAKRTTRNSTAAKKKRGDQSDTSN--SELEKEVKKLG 925

Human   830 KIGAARTTKKRIPNTKDFDSSEDEKHSKKGMDNQGHKNLKTSQEGSSDDAERKQERETFSSAEGT 894
            |..:.|                      ||:
Frog   926 KKDSVR----------------------KGL---------------------------------- 934

Human   895 VDKDTTIMELRDRLPKKQQASASTDGVDKLSGKEESFTSLEVRKVAETKEKSKHLKTKTCKKVQD 959
                                                            |:|||
Frog   935 ------------------------------------------------KQKSK------------ 939

Human   960 GLSDIAEKFLKKDQSDETSEDDKKQSKKGTEEKKKPSDFKKKVIKMEQQYESSSDGTEKLPEREE 1024
                      ||:::.|:| |:|.|::
Frog   940 ----------KKEENSESS-DEKNQNR-------------------------------------- 955

Human  1025 ICHFPKGIKQIKNGTTDGEKKSKKIRDKTSKKKDELSDYAEKSTGKGDSCDSSEDKKSKNGAYGR 1089
                           :...||||::|...|.||:
Frog   956 ---------------SQKAKKSKRVRTPASNKKE------------------------------- 974

Human  1090 EKKRCKLLGKSSRKRQDCSSSDTEKYSMKEDGCNSSDKRLKRIELRERRNLSSKRNTKEIQSGSS 1154
                                                                            |
Frog   975 ----------------------------------------------------------------S 975

Human  1155 SSDAEESSEDNKKKKQRTSSKKKAVIVKEKKRNSLRTSTKRKQADITSSSSSDIEDDDQNSIGEG 1219
            |||..|..::|                                     |.:|| ||
Frog   976 SSDLSEEEQEN-------------------------------------SHNSD-ED--------- 993

Human  1220 SSDEQKIKPVTENLVLSSHTGFCQSSGDEALSK--SVPVTVDDDDDDNDPENRIAKKMLLEEIKA 1282
             ||||||||:.||.|:|: |||.|||||||.:|  :.| |.:|||||:|||||||||||||||||
Frog   994 -SDEQKIKPLVENEVVSA-TGFVQSSGDEAGTKCGAAP-TEEDDDDDDDPENRIAKKMLLEEIKA 1055

Human  1283 NLSSD--EDGSSDDEPEEGKKRTGKQ---------NEENPGDEEAKNQVNSESDSDSEESKKPRY 1336
            |||||  |:.|||:|||||||...|.         ||::..|.::    :|:||||||..|||||
Frog  1056 NLSSDDVEEASSDEEPEEGKKSVAKSTTKTEDKDVNEDDKSDSDS----DSDSDSDSESEKKPRY 1116

Human  1337 RHRLLRHKLTVSDGESGE--EKKTKPKEHKEVKGRNRRKVSSEDSEDSDFQESGVSEEVSESE-- 1397
            ||.|||.|:::|||:|||  |||.|.|..|..|.|||||||||:|.....:.||||||:|||:
Frog  1117 RHHLLRRKISLSDGDSGEEKEKKDKAKNSKNGKRRNRRKVSSEESASDFHKSSGVSEEISESDDS 1181

Human  1398 DEQRPRTRSAKKAELEENQRSYKQKKKRRRIKVQEDS--SSENKSNSEEEEEEKEEEEEEEEEEE 1460
            |:||||||:||| |.|||||||||||||||||||:||  |..||.||                 |
Frog  1182 DDQRPRTRAAKK-EAEENQRSYKQKKKRRRIKVQDDSSDSKSNKGNS-----------------E 1228

Human  1461 EEEEDENDDSKSPGKGRKKIRKILKDDKLRTETQNALKEEEERRKRIAEREREREKLRE--VIEI 1523
            :.:.||:.|||||||||||||||:||||||||||||||||||||||||||||||:||||  |::.
Frog  1229 DGDHDEDSDSKSPGKGRKKIRKIIKDDKLRTETQNALKEEEERRKRIAERERERDKLRELQVVDT 1293

Human  1524 EDASPTKCPITTKLVLDEDEETKEPLVQVHRNMVIKLKPHQVDGVQFMWDCCCESVKKTKKSPGS 1588
            ||.||.|||:||||||||:|||||.|||||:.||.||||||||||||||||||||:|||||.|||
Frog  1294 EDVSPVKCPVTTKLVLDENEETKEALVQVHQKMVTKLKPHQVDGVQFMWDCCCESMKKTKKDPGS 1358

Human  1589 GCILAHCMGLGKTLQVVSFLHTVLLCDKLDFSTALVVCPLNTALNWMNEFEKWQEGLKDDEKLEV 1653
            |||||||||||||||||:|||||||.:|||||||||||||||.|||:|||||||:|:.|:|||||
Frog  1359 GCILAHCMGLGKTLQVVTFLHTVLLSEKLDFSTALVVCPLNTVLNWLNEFEKWQDGMDDEEKLEV 1423

Human  1654 SELATVKRPQERSYMLQRWQEDGGVMIIGYEMYRNLAQGRNVKSRKLKEIFNKALVDPGPDFVVC 1718
            .||||||||||||||:|||.::||::||||||||||.|||||||:||||||:|.|||||||||:|
Frog  1424 CELATVKRPQERSYMMQRWHQEGGILIIGYEMYRNLTQGRNVKSKKLKEIFHKTLVDPGPDFVIC 1488

Human  1719 DEGHILKNEASAVSKAMNSIRSRRRIILTGTPLQNNLIEYHCMVNFIKENLLGSIKEFRNRFINP 1783
            |||||||||.||:|||||||::|||||||||||||||:|||||||||||||||||||||||||||
Frog  1489 DEGHILKNELSAISKAMNSIKTRRRIILTGTPLQNNLVEYHCMVNFIKENLLGSIKEFRNRFINP 1553

Human  1784 IQNGQCADSTMVDVRVMKKRAHILYEMLAGCVQRKDYTALTKFLPPKHEYVLAVRMTSIQCKLYQ 1848
            ||||||||||:|||||||||||||||||||||||:|||||||||||||||||:||::.:||||||
Frog  1554 IQNGQCADSTLVDVRVMKKRAHILYEMLAGCVQRRDYTALTKFLPPKHEYVLSVRISPLQCKLYQ 1618

Human  1849 YYLDHLTG-VGNNSEGG-RGKAGAKLFQDFQMLSRIWTHPWCLQLDYISKENKGYFDE-DSMDEF 1910
            |||||||| ||   ||| |||:|.|||||||:|||||||||||||||||||||||||| |||:||
Frog  1619 YYLDHLTGAVG---EGGVRGKSGTKLFQDFQVLSRIWTHPWCLQLDYISKENKGYFDEDDSMEEF 1680

Human  1911 IASDSDETSMSLSSDDYTKKKKKGK-KGKKDSSSSGSGSDNDVEVIKVWNSRSRGG-GEGNVDET 1973
            |||||:|:||||||::....|||.| |||:::|||...|||||||||||||||||| |:...||.
Frog  1681 IASDSEESSMSLSSEEEVVNKKKAKGKGKRENSSSEEESDNDVEVIKVWNSRSRGGKGKDLNDEE 1745

Human  1974 GNNPSVSLKLEESKATSSSNPSSPAPDWYKDFVTDADAEVLEHSGKMVLLFEILRMAEEIGDKVL 2038
            .:|..|..|.||:||||||.|.|||.||||||||:||:.::|||||::||||||||||.:|||||
Frog  1746 ASNSPVVPKAEETKATSSSTPGSPAADWYKDFVTEADSSIMEHSGKIMLLFEILRMAEVLGDKVL 1810

Human  2039 VFSQSLISLDLIEDFLELASREKTED--KDKPLIYKGEGKWLRNIDYYRLDGSTTAQSRKKWAEE 2101
            ||||||||||||||||||||.||.|:  .:||:.|||:|||.||||||||||.|:.|:|||||||
Frog  1811 VFSQSLISLDLIEDFLELASTEKNEENASEKPVFYKGDGKWFRNIDYYRLDGQTSPQTRKKWAEE 1875

Human  2102 FNDETNVRGRLFIISTKAGSLGINLVAANRVIIFDASWNPSYDIQSIFRVYRFGQTKPVYVYRFL 2166
            |||.||:|||||:||||||||||||||||||||||||||||||||||||||||||.|||:|||||
Frog  1876 FNDSTNIRGRLFLISTKAGSLGINLVAANRVIIFDASWNPSYDIQSIFRVYRFGQIKPVFVYRFL 1940

Human  2167 AQGTMEDKIYDRQVTKQSLSFRVVDQQQVERHFTMNELTELYTFEPDLLDDPNSEKKKKRDTPML 2231
            ||||||:||||||:.||||||||:||||:|||||||||||||||||||||||||||||||:||||
Frog  1941 AQGTMEEKIYDRQIAKQSLSFRVIDQQQIERHFTMNELTELYTFEPDLLDDPNSEKKKKRETPML 2005

Human  2232 PKDTILAELLQIHKEHIVGYHEHDSLLDHKEEEELTEEERKAAWAEYEAEKKGLTMRFNIP--TG 2294
            ||||:|||||||.||:||.||||||||||||||.||||:||||||||||||||||.|||:.  ||
Frog  2006 PKDTVLAELLQILKEYIVTYHEHDSLLDHKEEEALTEEDRKAAWAEYEAEKKGLTNRFNVAAVTG 2070

Human  2295 TNLPPVSFNSQTPYIPFNLGALSAMSNQQLEDLINQGREKVVEATNSVTAVRIQPLEDIISAVWK 2359
            .|...|:.|||:.|:|.||||||::|||||||||||||||||||||::...||||||||||.|||
Frog  2071 ANYAQVNINSQSSYMPLNLGALSSLSNQQLEDLINQGREKVVEATNNIATARIQPLEDIISTVWK 2135

Human  2360 ENMNLSEAQVQALALSRQASQELDVKRREAIYNDVLTKQQMLISCVQRILMNRRLQQQYNQQQQQ 2424
            ||...:|||||:||||||:||||::||||||||||||||||||||||||||:||||.||||||||
Frog  2136 ENPTATEAQVQSLALSRQSSQELEIKRREAIYNDVLTKQQMLISCVQRILMSRRLQHQYNQQQQQ 2200

Human  2425 Q--MTYQQATLGHLMMPKPPNLIMNPSNYQQIDMRGMYQPVAGGMQPPPLQR-APPPMRSKNPGP 2486
            |  :..|||.|..|||.|.||:|::|||:.|||||||||   .|||...:|| ||..:|:|||||
Frog  2201 QQIVFQQQAALNRLMMQKNPNIIISPSNFSQIDMRGMYQ---AGMQGHQMQRNAPASIRAKNPGP 2262

Human  2487 SQGKSM 2492
            ||||.|
Frog  2263 SQGKKM 2268

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ATRX	NP_000480.3	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..146		99/144 (69%)
		ADDz_ATRX	167..270	CDD:277252	89/102 (87%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	445..516		29/170 (17%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	535..576		6/40 (15%)
		PxVxL motif	581..594		8/14 (57%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	593..614		10/20 (50%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	649..956		90/315 (29%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	968..1479		192/529 (36%)
		Interaction with DAXX	1189..1326		74/149 (50%)
		SNF2_N	1563..1889	CDD:278600	284/327 (87%)
		DEXDc	1588..1750	CDD:238005	136/161 (84%)
		DEGH box	1719..1722		2/2 (100%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1913..2000		56/88 (64%)
		Interaction with MECP2. /evidence=ECO:0000269\|PubMed:17296936	2010..2280		231/271 (85%)
		HELICc	2017..2163	CDD:238034	123/147 (84%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	2462..2492		17/30 (57%)
atrx	XP_002931858.1	ADDz_ATRX	166..269	CDD:277252	89/102 (87%)
		PTZ00121	<298..1088	CDD:173412	340/1161 (29%)
		HepA	<1213..1969	CDD:223627	620/775 (80%)
		DEXHc_ATRX	1330..1573	CDD:350826	213/242 (88%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	546	1.000	Domainoid score	I3021
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H416
Inparanoid	1	1.050	2143	1.000	Inparanoid score	I574
NCBI	1	1.000	-	-
OMA	1	1.010	-	-		QHG39559
OrthoDB	1	1.010	-	-		D111318at33208
OrthoFinder	1	1.000	-	-		FOG0003310
OrthoInspector	1	1.000	-	-		oto152053
Panther	1	1.100	-	-	LDO	PTHR46357
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X2684
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	12	12.080