DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment POU3F4 and Antp

DIOPT Version :9

Sequence 1:	NP_000298.3	Gene:	POU3F4 / 5456	HGNCID:	9217	Length:	361	Species:	Homo sapiens
Sequence 2:	NP_996167.1	Gene:	Antp / 40835	FlyBaseID:	FBgn0260642	Length:	378	Species:	Drosophila melanogaster

Alignment Length:	399	Identity:	71/399 - (17%)
Similarity:	114/399 - (28%)	Gaps:	185/399 - (46%)

- Green bases have known domain annotations that are detailed below.

Human    90 LGAIIHH-----------RSPHVAHHSPHTNHPNAWGASPAPN-------PSITSSG----QPLN 132
            :||.:||           .:..:.|:|.:.||.   |..|.|.       |.....|    |...
  Fly    20 MGADMHHGHYPGNGVTDLDAQQMHHYSQNANHQ---GNMPYPRFPPYDRMPYYNGQGMDQQQQHQ 81

Human   133 VYSQPGFTVSGMLEHGGLTPPPAAASAQSLHPVLREPPDHGELGSHHCQDHSDEETPTSDELEQF 197
            |||:|.   |...:.||:.|     .||:          :|:||... |....::.|:.::.:|.
  Fly    82 VYSRPD---SPSSQVGGVMP-----QAQT----------NGQLGVPQ-QQQQQQQQPSQNQQQQQ 127

Human   198 AKQFKQRRIKLGFTQADVGLALGTLYGNVFSQTTICRFEALQLSFKNMCKLKPLLN--KWLEEAD 260
            |:|..|:              |......|..|.|..:.:..|......|||:..:.  ..:.|.
  Fly   128 AQQAPQQ--------------LQQQLPQVTQQVTHPQQQQQQPVVYASCKLQAAVGGLGMVPEG- 177

Human   261 SSTGSPTSIDKIAA------------QGRKRKKRTSIEVSVKGVLETH----------------- 296
               |||..:|:::.            .|..:.:....:|.|..|.|.|
  Fly   178 ---GSPPLVDQMSGHHMNAQMTLPHHMGHPQAQLGYTDVGVPDVTEVHQNHHNMGMYQQQSGVPP 239

Human   297 ---------------------------------------------------FLKC-PKPAAQEIS 309
                                                               |.|| .:...::..
  Fly   240 VGAPPQGMMHQGQGPPQMHQGHPGQHTPPSQNPNSQSSGMPSPLYPWMRSQFGKCQERKRGRQTY 304

Human   310 SLADSLQLEKEV------------------------VRVWFCNRRQKEKR--------------- 335
            :...:|:||||.                        :::||.|||.|.|:
  Fly   305 TRYQTLELEKEFHFNRYLTRRRRIEIAHALCLTERQIKIWFQNRRMKWKKENKTKGEPGSGGEGD 369

Human   336 -MTPPGDQQ 343
             :|||...|
  Fly   370 EITPPNSPQ 378

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
POU3F4	NP_000298.3	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	99..131		10/42 (24%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	144..192		10/47 (21%)
		POU	186..260	CDD:197673	14/75 (19%)
		Homeobox	281..335	CDD:365835	19/146 (13%)
Antp	NP_996167.1	KLF1_2_4_N	<161..306	CDD:425360	17/148 (11%)
Antp	NP_996167.1	Homeobox	301..354	CDD:395001	11/52 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3844
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	1.030