DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ING3 and PHO23

DIOPT Version :9

Sequence 1:	NP_061944.2	Gene:	ING3 / 54556	HGNCID:	14587	Length:	418	Species:	Homo sapiens
Sequence 2:	NP_014302.3	Gene:	PHO23 / 855626	SGDID:	S000005041	Length:	330	Species:	Saccharomyces cerevisiae

Alignment Length:	410	Identity:	108/410 - (26%)
Similarity:	163/410 - (39%)	Gaps:	101/410 - (24%)

- Green bases have known domain annotations that are detailed below.

Human     4 LEDYLEMIEQLPMDLRDRFTEMREMDLQVQNAMDQLEQRVSEFFMNAKKNKPEWREEQMASIKKD 68
            |.|..:::|:.|:......|.:.|:|.:..::|..|.:|:.:|.........:.:...:.:|.|.
Yeast    11 LNDITDVLEEFPLATSRYLTLLHEIDAKCVHSMPNLNERIDKFLKKDFNKDHQTQVRLLNNINKI 75

Human    69 YYKALEDADEKVQLANQIYDLVDRHLRKLDQELAKFKMELEADNAGITEILERRSLELDTPSQPV 133
            |.:.:...:||:.:::.:.|.:||...:|  |||   .|:...|   |||  .|.|.|.     |
Yeast    76 YEELMPSLEEKMHVSSIMLDNLDRLTSRL--ELA---YEVAIKN---TEI--PRGLRLG-----V 125

Human   134 NNH---HAHSHTPVEK--RKYNPTSHHTTTDHIPEKKFKSEALLSTLTSDASKENTLGCRNNNST 193
            :||   |.| |..:||  .|.|..|         .:..|||:....:.::..:........:...
Yeast   126 DNHPAMHLH-HELMEKIESKSNSKS---------SQALKSESRREAMAANRRQGEHYSASTHQQD 180

Human   194 ASSNNAYNVNSSQPLGSYNIGSLSSGTGAGAITMAAAQAVQATAQMKEGRRTSSLKASYEAFKNN 258
            .|.|:|            |.|                 ..:..:|...|..|:|.|.:..|..||
Yeast   181 DSKNDA------------NYG-----------------GSRHESQDHTGNNTNSRKRANAANTNN 216

Human   259 DFQLGKEFSMARETVGYSSSSALMTTLTQNASSSAADSRSGRKSKNNNKSSSQQSSSSSSSSSLS 323
            .....|:......|...|.|:....|...|          ||            ..:|::|..:|
Yeast   217 ADPETKKRKRRVATTAVSPSTISTATAVNN----------GR------------IGTSTASRGVS 259

Human   324 SCSSSSTVVQEISQQTTVVPESDSNSQVD--WTYDPNEPRYCICNQVSYGEMVGCDNQDCPIEWF 386
            |..:|                  :||::.  .|.|..||.||.||||:||||||||..||.:|||
Yeast   260 SVGNS------------------NNSRISRPKTNDYGEPLYCYCNQVAYGEMVGCDGADCELEWF 306

Human   387 HYGCVGLTEAPKGKWYCPQC 406
            |..|:||...|||||||..|
Yeast   307 HLPCIGLETLPKGKWYCDDC 326

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ING3	NP_061944.2	ING	3..102	CDD:404028	21/97 (22%)
		TNG2	4..410	CDD:227367	108/410 (26%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	127..165		11/42 (26%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	286..325		6/38 (16%)
		PHD_ING3	362..406	CDD:277060	30/43 (70%)
PHO23	NP_014302.3	TNG2	5..330	CDD:227367	108/410 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	96	1.000	Domainoid score	I1858
eggNOG	1	0.900	-	-		E1_COG5034
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	106	1.000	Inparanoid score	I1578
Isobase	1	0.950	-	0	Normalized mean entropy	S2874
OMA	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000296
OrthoInspector	1	1.000	-	-		otm52828
orthoMCL	1	0.900	-	-		OOG6_107420
Panther	1	1.100	-	-	O	PTHR10333
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2364
SonicParanoid	1	1.000	-	-		X195
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	11	10.840