DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ING3 and ing-3

DIOPT Version :9

Sequence 1:	NP_061944.2	Gene:	ING3 / 54556	HGNCID:	14587	Length:	418	Species:	Homo sapiens
Sequence 2:	NP_496909.1	Gene:	ing-3 / 3564936	WormBaseID:	WBGene00013095	Length:	490	Species:	Caenorhabditis elegans

Alignment Length:	498	Identity:	120/498 - (24%)
Similarity:	217/498 - (43%)	Gaps:	108/498 - (21%)

- Green bases have known domain annotations that are detailed below.

Human     1 MLYLEDYLEMIEQLPMDLRDRFTEMREMDLQVQNAMDQLEQRVSEFFMNAKKNKPEWREEQMASI 65
            ||:|:|:|||:::||.:|::|..|:|.:|.:|::.:::..:.:::||.....|.||.:.::...:
Worm     1 MLFLDDFLEMLDELPAELKERSDEIRRIDNEVESRLNRNREAINDFFERTGVNMPEEQRKERCKV 65

Human    66 KKDYYKALED-ADEKVQLANQIYDLVDRHLRKLDQELAKFKMELEADNAGITEILERRSLELDTP 129
            .::.:..:.. |..|..:|.::.:|:.::...|::|...|:.|:||||:|:||::|:|..:
Worm    66 LQEEFSTIRVLAQRKYLIAEKMQELLKKYKVHLEKEKTTFQCEMEADNSGVTEMIEKRYTQ---- 126

Human   130 SQPVNNHHAHSHTPVEKRKY------------NPTSHHTTTDHIP----EKKFKSEALLS---TL 175
                   |..|.....|.:.            ..:|..:|....|    |.|.|.:.:|.   .|
Worm   127 -------HVESLLTARKERKRRHRVGGGGGGGGSSSRASTVASGPLLSKESKDKIQRILQEGVRL 184

Human   176 TSDASKENTLGCRNN----------------NSTASSNNAYNVNSSQ---PLGSYNIGSLSSGTG 221
            ..|.|.|:.....::                :....|:.|..|.|..   |:.........|.|.
Worm   185 RMDLSDESAQSALSSAIPSPAPRGRPPKIAKDQLLLSSAAMVVASDDCLTPVPPTPTARRRSNTN 249

Human   222 A--GAITMAAAQAVQATAQMKEGRRTS--SLKASYEAFKNNDFQLGKEFSMARETVG------YS 276
            |  |.:::.:|    .::.|..|..||  |...|..::.|    .|.:.|....|..      :|
Worm   250 ALRGTVSIPSA----LSSMMNRGESTSRFSPNPSERSWSN----AGIDESSPTPTTSLLMTPTFS 306

Human   277 SSSALM----TTLTQNASSSAADSRSGRKSK----------------NNNKSSSQQSSSSSSSSS 321
            |...::    |.:.||::...::||.||..|                .|:.:|........|:::
Worm   307 SGPHIVVSPTTPVLQNSAFVVSESRHGRTRKLTSRVQEMFKETLQRQRNHGNSIIALQERMSAAN 371

Human   322 LSSCSSSSTVVQEISQQTTVVPESDSNSQVDWTYDP-------------------NEPRYCICNQ 367
            |::.:..:......|.|:. :||.:..::.|....|                   :|..:|.||:
Worm   372 LAAAAQHAHAPTSSSPQSP-LPEIEGAAEDDDEEGPSYRIKRSHPMMAPGSEDEEDEMHWCFCNE 435

Human   368 VSYGEMVGCDNQDCPIEWFHYGCVGLTEAPKGKWYCPQCTAAM 410
            .|||:||.|||:.|.:.||||.|:|:.|.|.||||||:|...|
Worm   436 KSYGDMVQCDNRHCTLRWFHYPCIGMVEPPTGKWYCPRCEVTM 478

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ING3	NP_061944.2	ING	3..102	CDD:404028	24/99 (24%)
		TNG2	4..410	CDD:227367	117/493 (24%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	127..165		7/53 (13%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	286..325		11/54 (20%)
		PHD_ING3	362..406	CDD:277060	26/43 (60%)
ing-3	NP_496909.1	ING	3..101	CDD:289749	23/97 (24%)
ing-3	NP_496909.1	PHD_ING	430..474	CDD:276980	26/43 (60%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	57	1.000	Domainoid score	I7913
eggNOG	1	0.900	-	-		E1_COG5034
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	170	1.000	Inparanoid score	I3166
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG45961
OrthoDB	1	1.010	-	-		D1434088at2759
OrthoFinder	1	1.000	-	-		FOG0000296
OrthoInspector	1	1.000	-	-		otm14847
orthoMCL	1	0.900	-	-		OOG6_107420
Panther	1	1.100	-	-	LDO	PTHR10333
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2364
SonicParanoid	1	1.000	-	-		X195
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	14	13.960