Protein Alignment WDR5B and Nle

DIOPT Version :10

• Sequence 1: NP_061942.2
• Gene: WDR5B / 54554
• HGNCID: 17826
• Length: 330
• Species: Homo sapiens
• Sequence 2: NP_477294.2
• Gene: Nle / 33234
• FlyBaseID: FBgn0021874
• Length: 488
• Species: Drosophila melanogaster
• Alignment Length: 383
• Identity: 104/383 - (27%)
• Similarity: 163/383 - (42%)
• Gaps: 96/383 - (25%)

Human    34 KCT--LVGHTEAVSSVKFSPNGEWLASSSADRLIIIWGAYDGKYEKTLYGHNLEISDVAWSSDSS 96
            :||  :.||.|||.|:.|||:|..|||.|.|..:.:|.........|..||...:..|:|:.|..
  Fly   110 RCTSSMPGHAEAVVSLNFSPDGAHLASGSGDTTVRLWDLNTETPHFTCTGHKQWVLCVSWAPDGK 174

Human    97 RLVSASDDKTLKLWDVRSGKCL-KTLKGHSNYVFCCNF-----NPPSNLIISGSFDETVKIWEVK 155
            ||.|.....::.:||..:|:.. :.|.||..::.|..:     :|....:.|.|.|...:||:||
  Fly   175 RLASGCKAGSIIIWDPETGQQKGRPLSGHKKHINCLAWEPYHRDPECRKLASASGDGDCRIWDVK 239

Human   156 TGKCLKTLSAHSDPVSAVHFNCSGSLIVSGSYDGLCRIWDAASGQCLKTL--------------- 205
            .|:||..::.|::.|:||.:..:| ||.:.|.|...::|.||.|...:|.
  Fly   240 LGQCLMNIAGHTNAVTAVRWGGAG-LIYTSSKDRTVKMWRAADGILCRTFSGHAHWVNNIALSTD 303

Human   206 -----------------------------------------------VDDDNP------------ 211
                                                           ..|||.
  Fly   304 YVLRTGPFHPVKDRSKSHLSLSTEELQESALKRYQAVCPDEVESLVSCSDDNTLYLWRNNQNKCV 368

Human   212 --------PVSFVKFSPNGKYILTATLDNTLKLWDYSRGRCLKTYTGHKNEKYCIFANFSVTGGK 268
                    .|:.||:||:.|.|.:|:.|.:::||..|.|:.:.|:.||....|.:..:   ...:
  Fly   369 ERMTGHQNVVNDVKYSPDVKLIASASFDKSVRLWRASDGQYMATFRGHVQAVYTVAWS---ADSR 430

Human   269 WIVSGSEDNLVYIWNLQTKEIVQKLQGHTDVVISAACHPTENLIASAALENDKTIKLW 326
            .|||||:|:.:.:|::|||::.|:|.||.|.|......|..:.:||..  .||.||||
  Fly   431 LIVSGSKDSTLKVWSVQTKKLAQELPGHADEVFGVDWAPDGSRVASGG--KDKVIKLW 486

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
WDR5B	NP_061942.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..26
		WD40	<36..326	CDD:441893	101/379 (27%)
		WD 1	39..78		16/38 (42%)
		WD40 repeat	44..81	CDD:293791	13/36 (36%)
		WD 2	81..122		11/41 (27%)
		WD40 repeat	87..123	CDD:293791	10/36 (28%)
		WD 3	124..164		13/44 (30%)
		WD40 repeat	128..164	CDD:293791	12/40 (30%)
		WD 4	165..204		13/38 (34%)
		WD40 repeat	171..206	CDD:293791	12/96 (13%)
		DDB1-binding motif	188..192		1/3 (33%)
		WD 5	208..249		17/60 (28%)
		WD40 repeat	213..249	CDD:293791	14/35 (40%)
		WD 6	252..292		11/39 (28%)
		WD40 repeat	257..294	CDD:293791	11/36 (31%)
		WD 7	295..330		13/32 (41%)
		WD40 repeat	300..326	CDD:293791	8/25 (32%)
Nle	NP_477294.2	NLE	22..82	CDD:462380
		WD40	84..486	CDD:441893	102/381 (27%)
		WD40 repeat	123..159	CDD:293791	12/35 (34%)
		WD40 repeat	164..202	CDD:293791	10/37 (27%)
		WD40 repeat	208..249	CDD:293791	12/40 (30%)
		WD40 repeat	254..289	CDD:293791	13/35 (37%)
		WD40 repeat	296..372	CDD:293791	3/75 (4%)
		WD40 repeat	378..414	CDD:293791	14/35 (40%)
		WD40 repeat	420..456	CDD:293791	12/38 (32%)
		WD40 repeat	462..486	CDD:293791	8/25 (32%)