DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment POU3F3 and Antp

DIOPT Version :9

Sequence 1:	NP_006227.1	Gene:	POU3F3 / 5455	HGNCID:	9216	Length:	500	Species:	Homo sapiens
Sequence 2:	NP_996167.1	Gene:	Antp / 40835	FlyBaseID:	FBgn0260642	Length:	378	Species:	Drosophila melanogaster

Alignment Length:	423	Identity:	82/423 - (19%)
Similarity:	119/423 - (28%)	Gaps:	151/423 - (35%)

- Green bases have known domain annotations that are detailed below.

Human    86 NGGHMLSHAHQWVTALPHAAAAAAAAAAAAVEASSPWSGSAVGMAGSPQQPPQPPPPPPQGPDVK 150
            ||..|.......|.:.|.:.::.........:.:        |..|.|||..|....|.|....:
  Fly    70 NGQGMDQQQQHQVYSRPDSPSSQVGGVMPQAQTN--------GQLGVPQQQQQQQQQPSQNQQQQ 126

Human   151 GGAGRDDLHAGTALHHRGPPHLGPPPPPPHQ--GHPGGWGAAAAAAAAAAAAAAAAHLPSMAGGQ 213
            ..             .:.|..|....|...|  .||..........|:....||...|..:..|.
  Fly   127 QA-------------QQAPQQLQQQLPQVTQQVTHPQQQQQQPVVYASCKLQAAVGGLGMVPEGG 178

Human   214 QPPPQSLLYSQPGGFTVNGMLSAPPGPGGGGGGAGGGAQSLVHPGLVRGDT----PELAEHHHHH 274
            .||    |..|..|..:|..::.|...|              ||....|.|    |::.|.|.:|
  Fly   179 SPP----LVDQMSGHHMNAQMTLPHHMG--------------HPQAQLGYTDVGVPDVTEVHQNH 225

Human   275 HHHAHPH----------PPH--PHHAQGPP--HHGGGGGGAGPGLNSHDPHSDEDTPTSDDL-EQ 324
            |:.....          ||.  .|..||||  |.|..|....|..|.:...|...:|....: .|
  Fly   226 HNMGMYQQQSGVPPVGAPPQGMMHQGQGPPQMHQGHPGQHTPPSQNPNSQSSGMPSPLYPWMRSQ 290

Human   325 FAKQFKQRRIKLGFTQADVGLALGTLYGNVFSQTTICRFEALQLSFKNMCKLKPLLNKWLEEADS 389
            |.|..:::|                      .:.|..|::.|:|
  Fly   291 FGKCQERKR----------------------GRQTYTRYQTLEL--------------------- 312

Human   390 STGSPTSIDKIAAQGRKRKKRTSIEVSVKGALESHFLKCPKPSAQEITNLADSLQLEKEVVRVWF 454
                    :|.....|...:|..||:                        |.:|.|.:..:::||
  Fly   313 --------EKEFHFNRYLTRRRRIEI------------------------AHALCLTERQIKIWF 345

Human   455 CNRRQKEKR----------------MTPPGIQQ 471
            .|||.|.|:                :|||...|
  Fly   346 QNRRMKWKKENKTKGEPGSGGEGDEITPPNSPQ 378

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
POU3F3	NP_006227.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	32..63
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	122..190		14/69 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	231..319		26/105 (25%)
		POU	314..388	CDD:197673	9/74 (12%)
		Homeobox	409..463	CDD:395001	12/53 (23%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	461..500		5/27 (19%)
Antp	NP_996167.1	KLF1_2_4_N	<161..306	CDD:425360	40/184 (22%)
Antp	NP_996167.1	Homeobox	301..354	CDD:395001	18/105 (17%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3844
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	1.030