DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment POU3F3 and pdm2

DIOPT Version :9

Sequence 1:	NP_006227.1	Gene:	POU3F3 / 5455	HGNCID:	9216	Length:	500	Species:	Homo sapiens
Sequence 2:	NP_001285877.1	Gene:	pdm2 / 34673	FlyBaseID:	FBgn0004394	Length:	893	Species:	Drosophila melanogaster

Alignment Length:	414	Identity:	141/414 - (34%)
Similarity:	182/414 - (43%)	Gaps:	120/414 - (28%)

- Green bases have known domain annotations that are detailed below.

Human   115 AVEASSPWSGSAVGMAGSPQQPPQ-----------PPPPPPQGPDVKGGAGRDDLHAGTALHHRG 168
            |.|..|......:.:|..|::..:           ||.|....|:....|.:..||:...:..:.
  Fly   491 ARELDSELENEVLDLAPPPKRLAEEQEEEKVASVNPPQPVAFAPEEMHQALQLQLHSYIEMVRQL 555

Human   169 PPHLGPPP-------------------------------PPPHQGHPGGWGAAAAAAAAAAAAAA 202
            .|...|.|                               |.|....|        .|.:...:.:
  Fly   556 APEAFPNPNLATQFLLQNSLQALAQFQALQQMKQQQREDPLPSYSTP--------LAKSPLRSPS 612

Human   203 AAHLPSMAGGQQPPPQSLLYSQPGGFTVN--GMLSAPPGPGGGGGGAGGGAQSLVHPGLVRGDTP 265
            .:.:|..:..||..|       |...|.|  ||.||...|                      :||
  Fly   613 LSPVPRHSKSQQRTP-------PNSMTANSLGMSSAVMTP----------------------NTP 648

Human   266 ELAEHHHHHHHHAHPHPPHPHHAQGPPHHGGGGGGAGPGLNSHDPHSDEDTPTSDDLEQFAKQFK 330
            .:.:.            |....:...|..|.....|...|.    .|.|:|...::||||||.||
  Fly   649 SMQQQ------------PQLQQSTPKPTSGLTVASAMAKLE----QSPEETTDLEELEQFAKTFK 697

Human   331 QRRIKLGFTQADVGLALGTLYGNVFSQTTICRFEALQLSFKNMCKLKPLLNKWLEEADSS----- 390
            ||||||||||.|||||:|.||||.||||||.|||||.|||||||||||||.||||:|||:
  Fly   698 QRRIKLGFTQGDVGLAMGKLYGNDFSQTTISRFEALNLSFKNMCKLKPLLQKWLEDADSTVAKSG 762

Human   391 -------------TGSPTSIDKIAAQGRKRKKRTSIEVSVKGALESHFLKCPKPSAQEITNLADS 442
                         :.:|.||     .||:||||||||.:|:..||..||...||:::||:.|::.
  Fly   763 GGVFNINTMTSTLSSTPESI-----LGRRRKKRTSIETTVRTTLEKAFLMNCKPTSEEISQLSER 822

Human   443 LQLEKEVVRVWFCNRRQKEKRMTP 466
            |.::|||:|||||||||||||:.|
  Fly   823 LNMDKEVIRVWFCNRRQKEKRINP 846

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
POU3F3	NP_006227.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	32..63
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	122..190		15/109 (14%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	231..319		16/89 (18%)
		POU	314..388	CDD:197673	58/73 (79%)
		Homeobox	409..463	CDD:395001	31/53 (58%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	461..500		4/6 (67%)
pdm2	NP_001285877.1	POU	691..755	CDD:197673	54/63 (86%)
pdm2	NP_001285877.1	Homeobox	789..842	CDD:278475	30/52 (58%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3802
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810