DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment POU3F3 and nub

DIOPT Version :9

Sequence 1:	NP_006227.1	Gene:	POU3F3 / 5455	HGNCID:	9216	Length:	500	Species:	Homo sapiens
Sequence 2:	NP_001097153.1	Gene:	nub / 34669	FlyBaseID:	FBgn0085424	Length:	961	Species:	Drosophila melanogaster

Alignment Length:	427	Identity:	162/427 - (37%)
Similarity:	201/427 - (47%)	Gaps:	92/427 - (21%)

- Green bases have known domain annotations that are detailed below.

Human   102 PHAAAAAAAAAAAAVEASSPWSGSAVGMAGSPQQPPQPPPPPPQGPDVKGGAGRDDLHAGTALHH 166
            |::.|||||||||.  ||:..||.:..:|       .|....||......|.|.::
  Fly   547 PNSMAAAAAAAAAV--ASTMGSGISPLLA-------LPGMSSPQAQLAAAGLGMNN--------- 593

Human   167 RGPPHLGPPPPPP----HQ-------------------GHPGGWGAAAAAAAAAAAAAAA----- 203
              |...|...|..    ||                   ...|..|.|....|..|..|||
  Fly   594 --PLLTGSLSPQDFAQFHQLLQQRQVALTQQFNSYMELLRSGSLGLAQDDPALTAQVAAAQFLMQ 656

Human   204 AHLPSMAGGQQ-----PPPQSLLYSQPGGFTVNGMLSAPPGPGGGGGGAGGGAQSLVHPGLVRGD 263
            :.|.:::...|     ...|.....:|  ..:|..::..|        ......|:..|..:|..
  Fly   657 SQLQALSQASQQLQALQKQQQRQVDEP--LQLNHKMTQQP--------RSSTPHSIRSPIAIRSP 711

Human   264 TPELAEHHHHHHHHAHPHPPHPHHA---QG--PPHHGGGGGGAGPGLNSHDPH------------ 311
            .....:.||||||.....||....:   .|  .|.....|.....|..:..|.
  Fly   712 ASSPQQLHHHHHHPLQITPPSSAASLKLSGMLTPSTPTSGTQMSQGTTTPQPKTVASAAAARAAG 776

Human   312 --SDEDTPTSDDLEQFAKQFKQRRIKLGFTQADVGLALGTLYGNVFSQTTICRFEALQLSFKNMC 374
              |.|:|...::||||||.||||||||||||.|||||:|.||||.||||||.|||||.|||||||
  Fly   777 EPSPEETTDLEELEQFAKTFKQRRIKLGFTQGDVGLAMGKLYGNDFSQTTISRFEALNLSFKNMC 841

Human   375 KLKPLLNKWLEEAD---SSTG---SPTSIDKIAAQ----GRKRKKRTSIEVSVKGALESHFLKCP 429
            ||||||.|||::||   .:||   .|.::....:.    ||:||||||||.:::||||..||...
  Fly   842 KLKPLLQKWLDDADRTIQATGGVFDPAALQATVSTPEIIGRRRKKRTSIETTIRGALEKAFLANQ 906

Human   430 KPSAQEITNLADSLQLEKEVVRVWFCNRRQKEKRMTP 466
            ||:::|||.|||.|.:||||||||||||||||||:.|
  Fly   907 KPTSEEITQLADRLSMEKEVVRVWFCNRRQKEKRINP 943

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
POU3F3	NP_006227.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	32..63
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	122..190		15/90 (17%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	231..319		21/106 (20%)
		POU	314..388	CDD:197673	57/73 (78%)
		Homeobox	409..463	CDD:395001	37/53 (70%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	461..500		4/6 (67%)
nub	NP_001097153.1	DUF4472	315..>399	CDD:291409
		POU	791..855	CDD:197673	53/63 (84%)
		Homeobox	886..939	CDD:278475	36/52 (69%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3802
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810