DRSC/TRiP Functional Genomics Resources

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Protein Alignment SDK2 and DIP-epsilon

DIOPT Version :9

Sequence 1:NP_001138424.1 Gene:SDK2 / 54549 HGNCID:19308 Length:2172 Species:Homo sapiens
Sequence 2:NP_001137799.1 Gene:DIP-epsilon / 7354433 FlyBaseID:FBgn0259714 Length:467 Species:Drosophila melanogaster


Alignment Length:414 Identity:97/414 - (23%)
Similarity:164/414 - (39%) Gaps:92/414 - (22%)


- Green bases have known domain annotations that are detailed below.


Human   255 GVLLSGGISDHNRRLTIPNPTGSD--AGYYECEAVLRSSSVPSVVRGAYLS--VLEPPQFVKEPE 315
            |.|::..::       :...|||:  ||.               |.|:.|:  :.|.|:|....|
  Fly    17 GCLIASSVA-------LSTDTGSEGNAGN---------------VGGSTLNNVISEDPEFTDVIE 59

Human   316 RHITAEMEKVVDIPCQAKGVPPPSITW--YKDAAVVEVEK--LTR------FRQRNDGG----LQ 366
             :||....:.|.:.|..|.:....:.|  ::.:|::.|..  :||      ...::|..    |.
  Fly    60 -NITVPAGRNVKLACSVKNLGSYKVAWMHFEQSAILTVHNHVITRNPRISVTHDKHDKHRTWFLH 123

Human   367 ISGLVPDDTGMFQCFARNAAGEVQTSTYLAVTSIAPNITRGPLDSTVI--DGMSVVLACETSGAP 429
            |:.:..:|.|.:.|.......:.|......|  :.|||......|.:|  :|.:|.|.|:..|:|
  Fly   124 INNVQEEDRGRYMCQINTVTAKTQYGFVKVV--VPPNIDDALTSSDIIVREGDNVTLRCKAKGSP 186

Human   430 RPAITWQK--GERILASGSVQLPRFTPLESGSL---LISPTHISDAGTYTCLATNSRGVD----- 484
            .|.|.|::  |.:|:.:.::::   ..||:.||   .||..|:   |.|.|:|:|  ||.     
  Fly   187 EPTIKWKRDDGNKIVINKTLEV---HDLETDSLELERISRLHM---GAYLCIASN--GVPPSVSK 243

Human   485 --EASADL--VVWARTRITKPPQDQSVIKGTQASMVCGVTHDPRVTIRYIWEKDGATLGTES--- 542
              :.|.|.  :||.      |.|...:..|...::.|.:..:| .::.| |.::...:.|||   
  Fly   244 RIKVSVDFSPMVWI------PHQLVGIPIGFNITLECFIEANP-TSLNY-WTRENDQMITESSKY 300

Human   543 -------HPRIRLDRNGSLHISQTWSGDIGTYTCRVISAGGNDSRSAHLRVRQLPHAPEHPVATL 600
                   ||..:....  |.|:...|.|.|.|.|...:..|:...:..|.:...|.....|.   
  Fly   301 KTETIPGHPSYKATMR--LTITNVQSSDYGNYKCVAKNPRGDMDGNIKLYMSSPPTTQPPPT--- 360

Human   601 STVERRAINLTWTKPFDG--NSPL 622
            :|..||..........||  |:||
  Fly   361 TTTLRRTTTTAAEIALDGYINTPL 384

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
SDK2NP_001138424.1 Ig 27..109 CDD:299845
IG_like 40..109 CDD:214653
I-set 120..203 CDD:254352
Ig 132..210 CDD:299845
IG_like 222..304 CDD:214653 10/52 (19%)
IGc2 233..286 CDD:197706 7/32 (22%)
I-set 308..397 CDD:254352 20/102 (20%)
Ig 326..394 CDD:143165 15/81 (19%)
I-set 402..492 CDD:254352 32/105 (30%)
Ig 416..492 CDD:299845 27/89 (30%)
Ig 502..586 CDD:299845 20/93 (22%)
IG_like 502..586 CDD:214653 20/93 (22%)
FN3 590..681 CDD:238020 10/35 (29%)
FN3 693..786 CDD:238020
FN3 794..890 CDD:238020
FN3 895..983 CDD:238020
FN3 993..1087 CDD:238020
FN3 1099..1194 CDD:238020
FN3 1201..1290 CDD:238020
FN3 1301..1394 CDD:238020
FN3 1400..1484 CDD:238020
FN3 1503..1616 CDD:238020
FN3 1626..1719 CDD:238020
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1707..1729
FN3 1724..1805 CDD:238020
FN3 1837..1916 CDD:238020
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 2039..2067
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 2098..2172
PDZ-binding. /evidence=ECO:0000250|UniProtKB:Q6V4S5 2166..2172
DIP-epsilonNP_001137799.1 IG_like 59..155 CDD:214653 19/98 (19%)
Ig 69..139 CDD:143165 14/69 (20%)
IG_like 165..249 CDD:214653 27/91 (30%)
IGc2 172..237 CDD:197706 23/72 (32%)
IG_like 267..348 CDD:214653 18/84 (21%)
Ig 270..339 CDD:299845 16/72 (22%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG3510
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.810

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