DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment SDK2 and tutl

DIOPT Version :9

Sequence 1:NP_001138424.1 Gene:SDK2 / 54549 HGNCID:19308 Length:2172 Species:Homo sapiens
Sequence 2:NP_001303307.1 Gene:tutl / 46015 FlyBaseID:FBgn0010473 Length:1536 Species:Drosophila melanogaster


Alignment Length:1610 Identity:338/1610 - (20%)
Similarity:538/1610 - (33%) Gaps:460/1610 - (28%)


- Green bases have known domain annotations that are detailed below.


Human   269 LTIPNPTGSDAGYYECEAVLRSSSVPSVVRGA--YLSVLEPPQFVKEPERHITAEMEKVVDIPCQ 331
            |.:.|...||.|:|||:.|..:........|.  :|.|..||:|...||..|...:...:.:.||
  Fly   212 LNLTNIRESDQGWYECKVVFLNRDPKQHKNGTWFHLDVH
APPRFSVTPEDIIYVNLGDSIILNCQ 276

Human   332 AKGVPPPSITWYKDAAVVEVEKLTRFRQRNDG-GLQISGLVPDDTGMFQCFARNAAGEVQTSTYL 395
            |.|.|.|.|.|||||..|:.......  .||| .|:||.:..:|.|.:.|.|||..|:|..:..:
  Fly   277 ADGTPTPEILWYKDANPVDPSPTVGI--FNDGTELRISTIRHEDIGEYTCIARNGEGQVSHTARV 339

Human   396 AVTSIAPNITRGPLDSTVIDGMSVVLACETSGAP-RPAITW-QKGERILASGSVQLPRFTPLESG 458
            .:...|. |...|.:.|.::|..|:.:||....| ...:.| ::|..:....::: .|.|..:.|
  Fly   340 II
AGGAV-IMVPPTNQTKLEGEKVIFSCEAKAMPGNVTVRWYREGSPVREVAALE-TRVTIRKDG 402

Human   459 SLLISPTHISDAGTYTCLATNSRG-VDEASADLVVWARTRITKPPQDQSVIKGTQASMVCGVTHD 522
            ||:|:|....|:|.|.|..||..| ...|||.|.|....::|..|..|.:.......:.|.:...
  Fly   403 SLIINPIKPDDSGQYLCEVTNGIGDPQSASAYLSV
EYPAKVTFTPTVQYLPFRLAGVVQCYIKSS 467

Human   523 PRVTIRYI-WEKDGATLGTESHPRIRLDRNGSLHISQTWSGDIGTYTCRVISAGGNDSRSA--HL 584
            |:  ::|: |.||...|.......|.:..||||..::......|.|.|...:|.|....|.  .:
  Fly   468 PQ--LQYVTWTKDKRLLEPYQMKDIVVMANGSLLFTRVNEEHQGQYACTPYNAQGTAGASGVMDV 530

Human   585 RVRQLPHAPEHPVATLSTVERRAINLTWTKPFDG------NSPLIRY-------ILEMSENNAPW 636
            .||:.|.....|    .|:.:|.:..:.....|.      ..|.|::       :.|...|.   
  Fly   531 LVRKPPAFTVEP----ETLYQRKVGDSVEMHCDALEAEGTERPTIKWQRQEGEQLTESQRNR--- 588

Human   637 TVLLASVDPKATSVTVKGLVPARSYQFRLCAV-NDVGKGQFSKDTERVSLPEEPPTAPPQNVIAS 700
                  :.....::|::.| ....:.:..|.| |:|  ......|:.|....:|..  |.|:...
  Fly   589 ------IKISGGNITIENL-RREDFGYYQCVVSNEV--ATLMAVTQLVIEGTQPHA--PYNITGK 642

Human   701 GRTNQSIMIQWQPPPESHQNG--ILKGYIIRYCLAGLPVGYQFKNITDADVNNLLLEDLIIWTNY 763
            . |..||.:||.|   .:..|  ..:.|.|.:..||:. .:|..::|.:....:.:..|...|.|
  Fly   643 A-TESSITLQWLP---GYSGGSEYKQDYTIWFREAGVN-DWQTISVTPSGSTQVTINGLASGTTY 702

Human   764 EIEVAAYNSAGLGVYSSKVTEWTLQGVPTVPPGNVHAEATNSTTIRFTWNAPSPQFINGINQGYK 828
            |.:|...|..|.|:.|..:|..||:..|.. |.||.| ||.          |...|...:.....
  Fly   703 EFQVVGRNVLGDGMMSKVMTVRTLEDAPAA-PRNVKA-ATQ----------PPDSFFQLMPDEAD 755

Human   829 LIAWEPEQEEEVTMVTARPNFQDSIHVGFVSGLKKFTEYFTSVLCFTTPGDGPRSTPQLVRTHED 893
            |:|:                               |..||.:    .:.|....|.|:| |....
  Fly   756 LLAY-------------------------------FDIYFHT----DSRGTLVYSPPKL-RVKGP 784

Human   894 VPGPVGHLSFSEILDTSLKVSWQEPGEKNGILTGYRI------SWEEYNRTNTRVTHYLPNVTLE 952
            .|||..::|.:|:.:..| ::||.|.|:..|:..|.|      .|:..||...|     |..| :
  Fly   785 KPGPPRNVSVTEVSNGFL-ITWQSPLERAHIVKFYTIKYRTDAQWKTLNRGQIR-----PEET-Q 842

Human   953 YRVTGLTALTTYTIEVAAMTSKGQGQVSASTISSGVPPELPGPPTNLGISNIGPRSVTLQFRPGY 1017
            |.|..|....||...|.|.:.|  ...|:..:...||            :.:..:::|       
  Fly   843 YLVKNLVGGRTYYFRVLANSEK--SYESSDEVKFPVP------------ARVKHKAIT------- 886

Human  1018 DGKTSISRWLVEAQVGVVGEGEEWLLIH--------QLSNEPDARSMEVPDLNPFTCYSFRMRQV 1074
                          .|||| |..:.::.        ::.|:...|..| .:.|...|.....|.:
  Fly   887 --------------AGVVG-GILFFIVAIILSVCAVKICNKRKRRKQE-KEFNMVACRITDARNI 935

Human  1075 NIVGTSPPSQPSRKIQTLQAP-PDMAPANVSLRTASETSL--WLRWMP-----------LPEMEY 1125
            ........::.:..|.:.|.| .......:|..||...::  |: |.|           .|.:| 
  Fly   936 AANNHHLHNRSTGSISSGQVPLKKYKQTRISSLTAILIAILHWI-WPPDRCTNCHSIYSSPNLE- 998

Human  1126 NGNPESVGYKIKYSRSDGHGKTLSHVVQDRVERDYTIEDLEEWTEYRVQVQAFNAIGSGPWSQTV 1190
            :|:.:..|        .|..:::|     |::|...       ..:.:.|:..:.:|   :||..
  Fly   999 DGDEDDGG--------GGRRRSVS-----RIQRSLD-------GRFVLDVEGVSKLG---YSQQT 1040

Human  1191 VGRTRESVPSSG-----PTNVSALATTSSSMLVRWSEVPEADRNGLVLGYKVMYKEKDSDTQPRF 1250
            :......|...|     .:|||..:::.               :|..|..:.....:.|..:|  
  Fly  1041 LESGNVDVVDGGLFERRNSNVSQKSSSD---------------DGGFLSRRNFITARASWRRP-- 1088

Human  1251 WLVEGNSSRSAQ---------LTGLGKYVLYEVQVLAFTRIGDGSPSHPPILERTLDDVPGPPMG 1306
             ||..:|..|.|         |.||             .:||....:.||..:...|:.      
  Fly  1089 -LVASSSQLSLQSAADSARGFLQGL-------------LKIGAKQSAVPPNSQSYFDEA------ 1133

Human  1307 ILFPEVRTTSVRLIWQPPAAPNGIILAYQITHRLNTTTANTATVEVLAPSARQYTATGLKPESVY 1371
                 |.....:.:.:|..:.|.:   |....|......||.:.. |:...:.||.:.:.     
  Fly  1134 -----VSGARYQNVLRPYTSSNNL---YGNADRSRPLHINTISGS-LSQQQQLYTPSRIS----- 1184

Human  1372 LFRITAQTRKGWGEAAEALVVTTEKRDRPQPPSRPMVQQEDVRARSVLLSWEPGSDGLSPVRYYT 1436
              ||.:                          |.|  ||.....:.:|||  .|..|..|..:..
  Fly  1185 --RIFS--------------------------SSP--QQLQPHHQQLLLS--SGGSGAYPTHFSD 1217

Human  1437 IQTRELPSGRWALHSASVSHNASSFIVDRLKPFTSYKFRVKATNDIGDSEFSEESESLTTLQA-- 1499
            :.|...|:.     :...|||.||          .|::            :|:|..||.|:|.  
  Fly  1218 LSTVYPPNS-----AERSSHNLSS----------RYRY------------YSQELPSLRTIQEET 1255

Human  1500 ---------------APDEAP----------TILSVTPHTTTSVLIRWQPPAEDKINGILLGFRI 1539
                           .|.:.|          :..|..|.|      ||.|....:    |...|.
  Fly  1256 RRQQQQKQHPLEDHFVPLQLPSPPSWRSYYQSQASYRPRT------RWYPRHHSR----LFSNRQ 1310

Human  1540 RYRELLYE-GLRGFTLRGINNPGATWAELTSMYSMRNLSRPSLTQYELDNLNKH--RRYEIR-MS 1600
            :..|:|.. ......||...|||...|...        ||.|.:.:...|.:.|  ...|.| :.
  Fly  1311 QQHEMLSPLPQLNLNLRNSMNPGGLEASPE--------SRSSSSGFGSKNTSNHPGSTSEWRLLP 1367

Human  1601 VYNAVGEGPSSPPQE--VFVGEAVPTAAPRNVVVHGATATQLDVTWEPPPLDSQNGDIQGYKIYF 1663
            .|.|    |.|||:.  .|.|:......|     ||:.:.....|   ||          |.:..
  Fly  1368 PYRA----PPSPPKHSGYFGGQQAQGQTP-----HGSYSYPRATT---PP----------YTMAH 1410

Human  1664 WEAQRGNLTERVKTLFLAENSVKLKNLTGYTAYMVSVAAFNAAGDGPRSTPTQGQTQQAAPSAPS 1728
            |                                :..::..|||            |....|.||.
  Fly  1411 W--------------------------------LEMISRLNAA------------TDSNLPKAPC 1431

Human  1729 SVKFSELTTTSVNVSWEAPQFPNGILEGYRLVYEPCSPVDGVSKIVTVDV 1778
            .|..                   |.::|: ..::|.:|....|.::..|:
  Fly  1432 PVDV-------------------GSVDGH-YEFDPATPTPSASSMLREDL 1461

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
SDK2NP_001138424.1 Ig 27..109 CDD:299845
IG_like 40..109 CDD:214653
I-set 120..203 CDD:254352
Ig 132..210 CDD:299845
IG_like 222..304 CDD:214653 11/36 (31%)
IGc2 233..286 CDD:197706 8/16 (50%)
I-set 308..397 CDD:254352 32/89 (36%)
Ig 326..394 CDD:143165 27/68 (40%)
I-set 402..492 CDD:254352 28/92 (30%)
Ig 416..492 CDD:299845 25/78 (32%)
Ig 502..586 CDD:299845 20/86 (23%)
IG_like 502..586 CDD:214653 20/86 (23%)
FN3 590..681 CDD:238020 15/104 (14%)
FN3 693..786 CDD:238020 25/94 (27%)
FN3 794..890 CDD:238020 17/95 (18%)
FN3 895..983 CDD:238020 28/93 (30%)
FN3 993..1087 CDD:238020 12/101 (12%)
FN3 1099..1194 CDD:238020 18/107 (17%)
FN3 1201..1290 CDD:238020 18/102 (18%)
FN3 1301..1394 CDD:238020 12/92 (13%)
FN3 1400..1484 CDD:238020 18/83 (22%)
FN3 1503..1616 CDD:238020 30/128 (23%)
FN3 1626..1719 CDD:238020 11/92 (12%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1707..1729 4/21 (19%)
FN3 1724..1805 CDD:238020 10/55 (18%)
FN3 1837..1916 CDD:238020
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 2039..2067
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 2098..2172
PDZ-binding. /evidence=ECO:0000250|UniProtKB:Q6V4S5 2166..2172
tutlNP_001303307.1 V-set 137..250 CDD:284989 11/37 (30%)
IG_like 137..229 CDD:214653 8/16 (50%)
I-set 253..341 CDD:254352 32/89 (36%)
IGc2 268..331 CDD:197706 25/64 (39%)
I-set 346..437 CDD:254352 28/92 (30%)
Ig 349..437 CDD:299845 27/88 (31%)
Ig 459..530 CDD:299845 18/72 (25%)
IG_like 549..628 CDD:214653 12/90 (13%)
IGc2 551..617 CDD:197706 10/75 (13%)
FN3 633..725 CDD:238020 26/98 (27%)
FN3 786..874 CDD:238020 28/96 (29%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG3510
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.810

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