DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment SDK2 and robo2

DIOPT Version :9

Sequence 1:NP_001138424.1 Gene:SDK2 / 54549 HGNCID:19308 Length:2172 Species:Homo sapiens
Sequence 2:NP_001259868.1 Gene:robo2 / 44522 FlyBaseID:FBgn0002543 Length:1519 Species:Drosophila melanogaster


Alignment Length:1565 Identity:340/1565 - (21%)
Similarity:546/1565 - (34%) Gaps:477/1565 - (30%)


- Green bases have known domain annotations that are detailed below.


Human     4 LLIWTLLALHQIRAARAQDDVSPYFKTEPVRTQVHLEGNRLVLTCMAEGSWPLEFKWLHNNRELT 68
            ||:..|..|.|:.|.:.:   :|.....|:.|.|. :.:.....|.|||:.....:|..:.|||.
  Fly    72 LLLAGLNGLTQVGALKGE---NPRIIEHPMDTTVP-KNDPFTFNCQAEGNPTPTIQWFKDGRELK 132

Human    69 KFSLEYRYM-----------ITSLDRTHAGFYRCIVRNRMGALLQRQTEVQVAYM-GSFEEGEKH 121
            ..:..:|.|           |.|...:.||.|.|..:|..|....|...:|||:: ..|.....:
  Fly   133 TDTGSHRIMLPAGGLFFLKVIHSRRESDAGTYWCEAKNEFGVARSRNATLQVAFLRDEFRLEPAN 197

Human   122 QSVSHGEAAVIR--APRIASFPQPQVTWFRDGR--KIPPSSRIAITLENTLVILSTVAPDAGRYY 182
            ..|:.||.|::.  |||  ..|:||::|.::|:  .:..:.||.|.....|.|......|.||| 
  Fly   198 TRVAQGEVALMECGAPR--GSPEPQISWRKNGQTLNLVGNKRIRIVDGGNLAIQEARQSDDGRY- 259

Human   183 VQAVNDKNGDNKTSQPITLTVENVGGPADP--------IAPTIIIPPKNTSVVAGTSEVTLECVA 239
             |.|                |:||.|..:.        :.|.:|..|:|.:.|.|:| |..:|..
  Fly   260 -QCV----------------VKNVVGTRESATAFLKVHVRPFLIRGPQNQTAVVGSS-VVFQCRI 306

Human   240 NARPLIKLHIIWKKDGVLLSGG---------ISDHNRRLTIPNPTGSDAGYYECEAVLRSSSVPS 295
            ...||  ..::|::..   |||         :.|  |.|.:.:.|..|.|.|.|||   .::|..
  Fly   307 GGDPL--PDVLWRRTA---SGGNMPLRRVHVLED--RSLKLDDVTLEDMGEYTCEA---DNAVGG 361

Human   296 VVRGAYLSVLEPPQFVKEPERHITAEMEKVVDIPCQAKGVPPPSITW------------YKDAAV 348
            :.....|:|..||:||..|:..: .|:...|...|||.|.|.|::.|            |:|.. 
  Fly   362 ITATGILTVHAPPKFVIRPKNQL-VEIGDEVLFECQANGHPRPTLYWSVEGNSSLLLPGYRDGR- 424

Human   349 VEVEKLTRFRQRNDGGLQISGLVPDDTG-MFQCFARNAAGEVQTSTYLAVTS----IAPNITRGP 408
            :||......|    ..|.|:....:|:| :..|.|.||.|.|.:.|.::|.:    ..|.|.:||
  Fly   425 MEVTLTPEGR----SVLSIARFAREDSGKVVTCNALNAVGSVSSRTVVSVDTQFELPPPIIEQGP 485

Human   409 LDSTVIDGMSVVLACETSGAPRPAITW---------QKGERILASGSVQLPRFTPLESGSLLIS- 463
            ::.|:.....|||.|.|.|.|.|.::|         |:.||...|           ::|:|.|| 
  Fly   486 VNQTLPVKSIVVLPCRTLGTPVPQVSWYLDGIPIDVQEHERRNLS-----------DAGALTISD 539

Human   464 -PTHISDAGTYTCLATNSRGVDEASADLVVWARTRITKPPQDQSVIKGTQASMVCGVTHDPRVTI 527
             ..| .|.|.|||:|:|..|....|..|                                     
  Fly   540 LQRH-EDEGLYTCVASNRNGKSSWSGYL------------------------------------- 566

Human   528 RYIWEKDGATLGTESHPRIRLDRNGSLHISQTWSGDIGTYTCRVISAGGNDSRSAHLRVRQLPHA 592
                     .|.|.::|.|:..|          :.::.||                      |..
  Fly   567 ---------RLDTPTNPNIKFFR----------APELSTY----------------------PGP 590

Human   593 PEHPVATLSTVER--RAINLTWTKPFD-GNSPLIRYILEMSENNAP--WTVLLASVDPKATSVTV 652
            |..|    ..||:  .::.|:||:... |.|.|:.|::||...|..  |..:...|  :.|:.|.
  Fly   591 PGKP----QMVEKGENSVTLSWTRSNKVGGSSLVGYVIEMFGKNETDGWVAVGTRV--QNTTFTQ 649

Human   653 KGLVPARSYQFRLCAVNDVGKGQFSKDTERVSLPEEPPTAPPQNVIASGRTNQSIMIQWQPPPES 717
            .||:|..:|.|.:.|.|..|          :|||     :|....|..|                
  Fly   650 TGLLPGVNYFFLIRAENSHG----------LSLP-----SPMSEPITVG---------------- 683

Human   718 HQNGILKGYIIRYCLAGLPVGYQFKNITDADVNNLLLEDLIIWTNYEIEVAAYNS---AGLGVYS 779
                      .||..:||.:.....::...||..|....::..|:.::.....|.   .|..||:
  Fly   684 ----------TRYFNSGLDLSEARASLLSGDVVELSNASVVDSTSMKLTWQIINGKYVEGFYVYA 738

Human   780 SKV--------------TEWTLQGVPTVPPGNVHAEATNST-------------TIRFTWNAPSP 817
            .::              |...|....|....:..|.|..||             |.:....||:|
  Fly   739 RQLPNPIVNNPAPVTSNTNPLLGSTSTSASASASASALISTKPNIAAAGKRDGETNQSGGGAPTP 803

Human   818 QFINGINQGYKLIAWEPEQEEEVTMVTARPNFQDSIHVGFVSGLKKFTEYFTSVLCFTTPGDGPR 882
                 :|..|:::          |::........:|     :||.::|.|...::.|....:|..
  Fly   804 -----LNTKYRML----------TILNGGGASSCTI-----TGLVQYTLYEFFIVPFYKSVEGKP 848

Human   883 STPQLVRTHEDVPGPVGHLSFSEILDTS-LKVSWQEP--GEKNGILTGYRI------SWEEYNRT 938
            |..::.||.||||....:...:.:|::| :.:.|:.|  .:::|:|..|.:      :...::|.
  Fly   849 SNSRIARTLEDVPSEAPYGMEALLLNSSAVFLKWKAPELKDRHGVLLNYHVIVRGIDTAHNFSRI 913

Human   939 NTRVTHYLPNVTLEYRVTGLTALTTYTIEVAAMTSKGQGQVSASTISSGVPPELPGPPTNLGISN 1003
            .|.||....:.||.  :..||....||:.|||..:.|.|...       ||..|...|       
  Fly   914 LTNVTIDAASPTLV--LANLTEGVMYTVGVAAGNNAGVGPYC-------VPATLRLDP------- 962

Human  1004 IGPRSVTLQFRPGYDGKTSISR----------WLVEAQVGVVGEGEEWLLIHQLSNEPDARSMEV 1058
                 :|.:..|..:.:..|::          |.: ..:|.:      |.:..||          
  Fly   963 -----ITKRLDPFINQRYPINQDHVNDVLTQPWFI-ILLGAI------LAVLMLS---------- 1005

Human  1059 PDLNPFTCYSF-----RMRQVNIVGTSPPSQPSRKIQTLQAPPDMAPANVSLRTASETSLWLR-- 1116
                 |....|     .|.:.:.:.|...:..|   ..|:.|        ||...:....||.  
  Fly  1006 -----FGAMVFVKRKHMMMKQSALNTMRGNHTS---DVLKMP--------SLSARNGNGYWLDSS 1054

Human  1117 -----WMPLP-----EMEYN------------GNPESVGYKIKYSRSDGHGKTLSHVV-----QD 1154
                 |.|.|     ||:.:            |:|...|.....|...|.|.:....:     .:
  Fly  1055 TGGMVWRPSPGGDSLEMQKDHIADYAPVCGAPGSPAGGGTSSGGSGGAGSGASGGDDIHGGHGSE 1119

Human  1155 RVERDYTIEDLEEWTEYRVQVQAFNAIGSGPWSQTVVGRTRESVPSSGPTNVSALAT---TSSSM 1216
            |.::.|..|.....|:| .:|.:|   |..|   :..||...:.|:  |...|::.:   .....
  Fly  1120 RNQQRYVGEYSNIPTDY-AEVSSF---GKAP---SEYGRHGNASPA--PYATSSILSPHQQQQQQ 1175

Human  1217 LVRWSEVPEADRNGLVLGYKVM------YKEKDSDTQPRFWLVEGNSSRSAQLTGLGKYVLYEVQ 1275
            ..|:.:.|       |.||.:.      |:::....|            .||.|......|.:.|
  Fly  1176 QPRYQQRP-------VPGYGLQRPMHPHYQQQQHQQQ------------QAQQTHQQHQALQQHQ 1221

Human  1276 VLAFTRIGDGSPSHPPILERTLDDVPGPPMGILFPEVRTTSVRLIWQPPAAPNGIILAYQI---- 1336
            .|                         ||..| :.::.|||.  |:.....|:..:.:.|.    
  Fly  1222 QL-------------------------PPSNI-YQQMSTTSE--IYPTNTGPSRSVYSEQYYYPK 1258

Human  1337 -----THRLNTTTANTATVEVLAPSARQYTATGLKPESVYLFRITAQTRKGWGEAAEALVVTTEK 1396
                 .|......:|..|.|. ||.|:|.:....:..||...::......| .|:|...|:.|::
  Fly  1259 DKQRHIHITENKLSNCHTYEA-APGAKQSSPISSQFASVRRQQLPPNCSIG-RESARFKVLNTDQ 1321

Human  1397 RDRPQ 1401
            ....|
  Fly  1322 GKNQQ 1326

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
SDK2NP_001138424.1 Ig 27..109 CDD:299845 22/92 (24%)
IG_like 40..109 CDD:214653 19/79 (24%)
I-set 120..203 CDD:254352 23/86 (27%)
Ig 132..210 CDD:299845 23/81 (28%)
IG_like 222..304 CDD:214653 24/90 (27%)
IGc2 233..286 CDD:197706 16/61 (26%)
I-set 308..397 CDD:254352 29/101 (29%)
Ig 326..394 CDD:143165 23/80 (29%)
I-set 402..492 CDD:254352 33/100 (33%)
Ig 416..492 CDD:299845 28/86 (33%)
Ig 502..586 CDD:299845 7/83 (8%)
IG_like 502..586 CDD:214653 7/83 (8%)
FN3 590..681 CDD:238020 27/95 (28%)
FN3 693..786 CDD:238020 16/109 (15%)
FN3 794..890 CDD:238020 19/108 (18%)
FN3 895..983 CDD:238020 23/96 (24%)
FN3 993..1087 CDD:238020 13/108 (12%)
FN3 1099..1194 CDD:238020 25/123 (20%)
FN3 1201..1290 CDD:238020 15/97 (15%)
FN3 1301..1394 CDD:238020 23/101 (23%)
FN3 1400..1484 CDD:238020 1/2 (50%)
FN3 1503..1616 CDD:238020
FN3 1626..1719 CDD:238020
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1707..1729
FN3 1724..1805 CDD:238020
FN3 1837..1916 CDD:238020
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 2039..2067
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 2098..2172
PDZ-binding. /evidence=ECO:0000250|UniProtKB:Q6V4S5 2166..2172
robo2NP_001259868.1 Ig1_Robo 90..185 CDD:143317 24/95 (25%)
I-set 91..184 CDD:254352 23/93 (25%)
I-set 190..279 CDD:254352 28/108 (26%)
Ig2_Robo 193..279 CDD:143201 27/105 (26%)
I-set 283..370 CDD:254352 27/97 (28%)
Ig 300..370 CDD:299845 20/79 (25%)
Ig 388..>457 CDD:299845 19/73 (26%)
I-set 479..561 CDD:254352 31/93 (33%)
Ig 496..561 CDD:143165 26/76 (34%)
FN3 588..681 CDD:238020 31/113 (27%)
FN3 <817..856 CDD:238020 8/43 (19%)
fn3 864..952 CDD:278470 22/89 (25%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.910

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