DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment SDK2 and kek6

DIOPT Version :9

Sequence 1:	NP_001138424.1	Gene:	SDK2 / 54549	HGNCID:	19308	Length:	2172	Species:	Homo sapiens
Sequence 2:	NP_001263151.1	Gene:	kek6 / 43729	FlyBaseID:	FBgn0039862	Length:	843	Species:	Drosophila melanogaster

Alignment Length:	771	Identity:	146/771 - (18%)
Similarity:	236/771 - (30%)	Gaps:	292/771 - (37%)

- Green bases have known domain annotations that are detailed below.

Human   467 ISDAGTYTCLATNSRGVDEASADLVVWARTRITKPPQDQSVIKGTQAS-MVCGVTHDPRVTIRYI 530
            :|.|...||..||.:    .||   :.:..::|..|...|    |:.. :|....|.|     |:
  Fly    36 LSCASNCTCKWTNGK----KSA---ICSSLQLTTIPNTLS----TELQVLVLNDNHIP-----YL 84

Human   531 WEKDGATLGTESHPRIRLD------------RNGSLHISQTWSGD----------IGTYTCRVIS 573
            ..::.:|||..:..||.|.            ||..:.:....|.:          :|....|::.
  Fly    85 NREEFSTLGLLNLQRIYLKKSEVQYIHKESFRNLKILVEIDLSDNKLEMLDKDTFMGNDRLRILY 149

Human   574 AGGND-SRSAHLRVRQLPHAPEHPVATLSTVERRAINLTWTKPFD-GNSPLIRYI---------- 626
            ..||. .|.|..:...|||        |.|::.....:::..|.. .|..|:.::
  Fly   150 LNGNPLKRLAAYQFPILPH--------LRTLDMHDCLISYIDPMSLANLNLLEFLNLKNNLLESL 206

Human   627 -------------LEMSENNAPWTVLLASVDPKATSVTVKGLVPARSY--QFRLCAVNDVGKG-Q 675
                         |.:.||  ||            ....| |...|.:  ..||.:|:.|.|| .
  Fly   207 SEYVFQHMANLKTLSLEEN--PW------------QCNCK-LRKFRGWYVNSRLSSVSLVCKGPP 256

Human   676 FSKDTERVSLPEEPPTAPP----------QNVIASGRTNQSIMIQWQPPPESHQNGILKGYIIRY 730
            ..||....|:.:|....||          ||:.....|..|.::...|.||....  |.|.|:
  Fly   257 AQKDRTWDSVDDELFGCPPRVEIFNNEEVQNIDIGSNTTFSCLVYGDPLPEVAWE--LNGKIL-- 317

Human   731 CLAGLPVGYQFKNITDADVNNLLLEDLII-----WTNY------EIEVAAY-----NSAG----- 774
                             |.:|:|.|...|     |:|.      .::...|     ||.|
  Fly   318 -----------------DNDNVLFESESIASDKLWSNLTVFNVTSLDAGTYACTGSNSIGSMTQN 365

Human   775 LGVYSSKVTEWTLQGVPTVPPGNVHAEATNSTTIRFTWNAPSPQFINGINQGYKLIAWEPEQEEE 839
            :.:|.|::.:..|:..|..                                     .|
  Fly   366 ISIYLSEIVQHVLEKTPET-------------------------------------FW------- 386

Human   840 VTMVTARPNFQDSIHVGFVSGLKKFTEYF-----TSVLCFTTPGDGPRSTPQLVRTHEDVPGPVG 899
                          :.|.:.|:  |...|     :.|:|..     .|:|.|  ..|.:..|...
  Fly   387 --------------YFGLIMGI--FGTVFLLISISFVVCLC-----KRTTRQ--HRHANKAGVKS 428

Human   900 HLSFSE----ILDTSLKVSWQEPGEKNGI------------------LTGYRISWEEYNRTNTRV 942
            .:||::    :||:|:..:..:.|:..||                  .....|...|.:|..:.:
  Fly   429 SVSFNDQEKKLLDSSVTTTTNDRGDSYGIDNQPTSIGMNKGDSAGMGFNQIEIHAVESHRHGSML 493

Human   943 THYLPNVTLEYRVTGLTALTTYTIEVAAMTSKGQGQVSASTISSGVPPELPGP-----PTNLGI- 1001
            ....|.   :.:|.|...:....::|...|.   |.:|..|..:|.....|..     |.|:|:
  Fly   494 VQQQPQ---QQQVAGGGGMRQQLMQVKDSTC---GMMSVPTSMAGHAHSHPAQISEEFPLNVGVF 552

Human  1002 -------SNIGPRSVTLQFRPGYDGKTSISRWLVEAQVGVVGEGEEWLLIHQLSNEPDARSMEVP 1059
                   |||.|       .|.:.|...|       :|.|.   ::.|....|:..||.  :.:|
  Fly   553 PPPPEFCSNIVP-------NPAFGGNIFI-------RVSVT---QDMLDGADLNMYPDL--LNIP 598

Human  1060 DLNPFTCYSFRMRQVNIVGTSPPSQPSRKIQTLQAPPDMAPANVSLR--TASETSL 1113
            .         ||:.|...|....:.|..:..||       |.:.:.|  ...:|||
  Fly   599 K---------RMQDVQESGAGAVAVPEGQFATL-------PRHTARRGILKKDTSL 638

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
SDK2	NP_001138424.1	Ig	27..109	CDD:299845
		IG_like	40..109	CDD:214653
		I-set	120..203	CDD:254352
		Ig	132..210	CDD:299845
		IG_like	222..304	CDD:214653
		IGc2	233..286	CDD:197706
		I-set	308..397	CDD:254352
		Ig	326..394	CDD:143165
		I-set	402..492	CDD:254352	8/24 (33%)
		Ig	416..492	CDD:299845	8/24 (33%)
		Ig	502..586	CDD:299845	22/107 (21%)
		IG_like	502..586	CDD:214653	22/107 (21%)
		FN3	590..681	CDD:238020	23/117 (20%)
		FN3	693..786	CDD:238020	25/123 (20%)
		FN3	794..890	CDD:238020	10/100 (10%)
		FN3	895..983	CDD:238020	19/109 (17%)
		FN3	993..1087	CDD:238020	23/106 (22%)
		FN3	1099..1194	CDD:238020	5/17 (29%)
		FN3	1201..1290	CDD:238020
		FN3	1301..1394	CDD:238020
		FN3	1400..1484	CDD:238020
		FN3	1503..1616	CDD:238020
		FN3	1626..1719	CDD:238020
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1707..1729
		FN3	1724..1805	CDD:238020
		FN3	1837..1916	CDD:238020
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	2039..2067
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	2098..2172
		PDZ-binding. /evidence=ECO:0000250\|UniProtKB:Q6V4S5	2166..2172
kek6	NP_001263151.1	leucine-rich repeat	71..96	CDD:275380	7/29 (24%)
		LRR_8	96..155	CDD:290566	10/58 (17%)
		leucine-rich repeat	97..120	CDD:275380	5/22 (23%)
		leucine-rich repeat	121..144	CDD:275380	2/22 (9%)
		LRR_4	144..186	CDD:289563	11/49 (22%)
		leucine-rich repeat	145..168	CDD:275380	6/22 (27%)
		leucine-rich repeat	169..216	CDD:275380	5/46 (11%)
		LRRCT	225..274	CDD:214507	16/63 (25%)
		Ig	295..367	CDD:143165	18/92 (20%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910