DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment SDK2 and plum

DIOPT Version :9

Sequence 1:	NP_001138424.1	Gene:	SDK2 / 54549	HGNCID:	19308	Length:	2172	Species:	Homo sapiens
Sequence 2:	NP_001163744.1	Gene:	plum / 43197	FlyBaseID:	FBgn0039431	Length:	1298	Species:	Drosophila melanogaster

Alignment Length:	1417	Identity:	273/1417 - (19%)
Similarity:	455/1417 - (32%)	Gaps:	487/1417 - (34%)

- Green bases have known domain annotations that are detailed below.

Human   157 SSRIAITLENTLVILSTVAP---DAGRYYVQAVNDKNGDNKTSQPITLTVENVGGPADP-IAPTI 217
            :.|:.:|.|:|.|..:...|   .|.:.|:|.           |...:|...:..|..| ..|.|
  Fly    26 NGRLTLTKESTTVAAAVAQPKNSTALQPYLQI-----------QKHAVTRLTISKPHSPYYLPCI 79

Human   218 -IIPPKNTSVVAGTSEVTLECVANARPLIKLHIIWKKDGVLLSGGISDHNRRLTIPNPTGSDA-G 280
             |:.|.|..    .....:.|......::...:.::|:...    |.|:.   |:..||...| |
  Fly    80 PILTPYNHD----QDNQPIYCSWYRNDVVVEQVSYRKNDFF----IYDNG---TLRLPTNEKASG 133

Human   281 YYECEAVLRSSSVPS---VVRGAYLSVLEPPQFVKEPERHITAEMEKVVDIPCQAKGVPPPSITW 342
            .|.|:.....|:|.|   .|....|..|.|.|   :...:|:|...|.:.:.|....||....:|
  Fly   134 EYYCKIEWDESAVISDRITVEYPVLKRLFPGQ---QQAANISALENKPLVLSCPFLSVPAARFSW 195

Human   343 Y--------KDAAVVEVEKLTRFRQRNDGGLQISGLVPDDTGMFQCFARNAAG------------ 387
            |        .::|::    ||      :|.|.:..|..:..|.::|.|:|...
  Fly   196 YFGNDSLTNDNSALI----LT------NGTLILRHLRLEQAGKYKCVAQNTFASKTHRQFIWQLQ 250

Human   388 -EVQTSTY-----LAVTSIAPNITRGPL-----DSTVI--DGMSVVLACETSGAPRPAITWQKGE 439
             |.:.:|:     ..:|..|  ::...|     ::||.  .|.||:|.|.......| |.|.
  Fly   251 VEPKDATFYPKNEAGITETA--VSEAQLLPAFQNATVFVPAGGSVLLQCHAVADFVP-IVWY--- 309

Human   440 RILASGSVQLP--RFTPLESGSLLISPTHISDA---GTYTCLATNSRGVDEASADLVVWARTRIT 499
                   :|.|  :...|.:.|:..|.|:.|.|   |.|:|:..    ::..:..::|....||.
  Fly   310 -------LQPPNNKMVRLSNNSVAYSITNASIARHEGRYSCITP----LETQNFQVIVTTPPRIV 363

Human   500 KPPQDQSVIKGTQASMVCGVTHDPRVTIRYIWEKDGATLGTESHPRIRLDRNGSLHISQTWSGDI 564
            .....:.|..|...::.|.....|..:|  .|..:|..|.:.   ..|......||:....|.:.
  Fly   364 SRLPVEVVYIGLSRTLTCRAEGHPEPSI--TWYHNGVHLNSS---YTRYISGNELHVHSFDSKEE 423

Human   565 GTYTCRVISAGGNDSRSAHLRV-RQLPHAPEHPVATLSTVER--RAINLTWTKPFDGNSPLIRYI 626
            |.|.|...:..|.||.:..||. |||...  :|:..:.....  .:||:|    ||..:....::
  Fly   424 GIYQCVARNVAGEDSATGELRFNRQLEEV--NPLQNIRCYPHSFHSINIT----FDSRTLTSMFV 482

Human   627 LEMSENNA-PWTVLLASVDP----KATSVTVKGLVPARSYQ-FRLCAVNDVGKGQFSKDTERVSL 685
            :.:..||. .||    |..|    :.:.|.:...:|.  |: |.|..              ||..
  Fly   483 VYIVRNNPHSWT----SFSPMKLNQTSYVVISTDLPV--YEPFALIT--------------RVLF 527

Human   686 P-EEPPT---APPQNVIASGRT------NQSIM-----------IQW------------------ 711
            | .|..|   .|.|.:::|.|:      .|.:|           ::|
  Fly   528 PTTEVRTGTLVPQQMILSSLRSTPVTCCTQGLMLRPIAVGNDTFVKWSQGQLENKKYFILQFSIN 592

Human   712 --QPPPESHQNGILKGYI---------IRYCLAGL-PVGYQ------------------------ 740
              .|.|....||.|:|.:         :|:.|..: |:...
  Fly   593 HTHPHPAQLLNGSLQGTLTSVEEKADQVRHHLTEIQPLNQSAAATVLRNVEHEDNVVDDTLELED 657

Human   741 --FKNITDADVNNLLLED--------LIIWTNYEIEVAAYNSAGLGVYSSKVTEWTLQGVPTVPP 795
              |..:.||.|..:||:.        |||.|..|.         || ...:..:|.:....|...
  Fly   658 DIFSLVVDASVTGILLQRFTRIKMRVLIITTENEF---------LG-QDFRYVQWKIIENGTSEQ 712

Human   796 GNV--HAEATNSTTIRFTWNAPSPQFINGINQGYKLIAWEPEQEEEVTMVTARPNFQD---SIHV 855
            .|:  ......|..:.|       :|::.:|:.. ::....|.:.::::.:..|..||   :..:
  Fly   713 SNMPFRLVTRESRALAF-------KFLDSLNETC-VLECHTEIQAQMSLPSQDPKCQDRNIANSL 769

Human   856 GFVSGLKKFTEY---FTSVLCFTTPGDGPRSTPQLVRTHEDVPGPVGHLSFSEILDTSLKVSWQE 917
            ..|:|||..|.|   |.:.......||...      :|.:|.||.:.:...  |....||:.|:.
  Fly   770 LLVTGLKPDTRYNLHFYNCKTRIFYGDIDE------KTEQDPPGTISNSKL--IKQNGLKLMWEP 826

Human   918 PGEKNGILTGYRISWEEYNRTN-------TRVTHYLPNVTLEYRVTGLTALTTYTIEVAAMTSKG 975
            |...||.:..|.|.|...|.|:       |:.::..|||:       .||.....:.|...|..|
  Fly   827 PINPNGRVHHYDIRWSLDNVTHEAIVKECTKCSYKFPNVS-------ETAKIHVAVRVMGDTGAG 884

Human   976 -----------------QGQVSASTISSGV-------------------------PPELPGP--- 995
                             :.:.|.|.:.||:                         .....||
  Fly   885 APMYFDMINNNHTWLKEESESSHSEVYSGIAIGSLLSIACVFLFGLFIIFQQRNFKARAQGPTHL 949

Human   996 --PTNLGISNI------------GPRSVTLQFRPGYDGKTSI--SRWLVE-------------AQ 1031
              ||::...|:            |....||| :..::.:|.|  ||:.:|             |.
  Fly   950 TTPTDINFGNLSSASGMPGDSAGGLSGGTLQ-QDCHEMQTLIPRSRYHIELLPEHSLEYQTSTAA 1013

Human  1032 VGVV----GEGEEWLL-----------------IHQLSNEP--------------------DARS 1055
            |.||    |.|...:.                 :|.||..|                    :|::
  Fly  1014 VAVVHLANGNGSVQVARRSDQDGAAQGDLGIAGVHNLSQLPLCGVGGTSPERKTVQDAMLQEAKA 1078

Human  1056 MEVPDLNPFTCYSFRMRQVNIVGTSPPSQ---PSRKIQTLQAPPDMAP----------------- 1100
            ..:|         :|....|.|..|...|   ||.....:..||:..|
  Fly  1079 FYIP---------YRHTPPNAVALSSSKQCAVPSGSELEVIVPPNSLPLVTTMPGLGVVGGGGSG 1134

Human  1101 -----------ANVSLRTASETSLWLRWMPLPEMEYNGNPESVGYK--IKYSRS-DG----HGKT 1147
                       .::|..:||.:|             ||:.:...:.  :::|.| ||    ..:.
  Fly  1135 GGGVGGSSRRSGSLSSSSASSSS-------------NGSSKKQFHTNFVRHSNSNDGIYLLAEEE 1186

Human  1148 LSHVVQDRVERDYTIEDLEEWTEYRVQVQAFNAIGSGPWSQT-------------VVGRTRE--- 1196
            .:..:....||:|....|....:....|.   ..|.|.::.|             ...:.|:
  Fly  1187 AAATLTPTSEREYAAVCLTNGFKLPADVA---KSGGGTYNTTNNNNSSTNTSQKSATAKERQPRG 1248

Human  1197 ------------SVPSSGPTNVSALATTSSSMLVRWSEV------PEADRNG 1230
                        .||::||.:|:  ...||::...|...      .:.|.||
  Fly  1249 NGNPISFSHNACKVPANGPASVN--VNHSSAVKQSWPAATVVHRRAQVDPNG 1298

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
SDK2	NP_001138424.1	Ig	27..109	CDD:299845
		IG_like	40..109	CDD:214653
		I-set	120..203	CDD:254352	10/48 (21%)
		Ig	132..210	CDD:299845	11/55 (20%)
		IG_like	222..304	CDD:214653	17/85 (20%)
		IGc2	233..286	CDD:197706	11/53 (21%)
		I-set	308..397	CDD:254352	21/114 (18%)
		Ig	326..394	CDD:143165	16/88 (18%)
		I-set	402..492	CDD:254352	22/101 (22%)
		Ig	416..492	CDD:299845	19/80 (24%)
		Ig	502..586	CDD:299845	19/83 (23%)
		IG_like	502..586	CDD:214653	19/83 (23%)
		FN3	590..681	CDD:238020	17/98 (17%)
		FN3	693..786	CDD:238020	29/173 (17%)
		FN3	794..890	CDD:238020	18/103 (17%)
		FN3	895..983	CDD:238020	24/111 (22%)
		FN3	993..1087	CDD:238020	32/169 (19%)
		FN3	1099..1194	CDD:238020	19/142 (13%)
		FN3	1201..1290	CDD:238020	9/36 (25%)
		FN3	1301..1394	CDD:238020
		FN3	1400..1484	CDD:238020
		FN3	1503..1616	CDD:238020
		FN3	1626..1719	CDD:238020
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1707..1729
		FN3	1724..1805	CDD:238020
		FN3	1837..1916	CDD:238020
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	2039..2067
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	2098..2172
		PDZ-binding. /evidence=ECO:0000250\|UniProtKB:Q6V4S5	2166..2172
plum	NP_001163744.1	IG_like	170..241	CDD:214653	18/80 (23%)
		IGc2	175..235	CDD:197706	15/69 (22%)
		IG_like	284..356	CDD:214653	21/86 (24%)
		I-set	360..443	CDD:254352	20/87 (23%)
		IGc2	378..435	CDD:197706	13/61 (21%)
		FN3	804..886	CDD:238020	24/90 (27%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4221
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900