DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment SDK2 and klg

DIOPT Version :9

Sequence 1:	NP_001138424.1	Gene:	SDK2 / 54549	HGNCID:	19308	Length:	2172	Species:	Homo sapiens
Sequence 2:	NP_524454.2	Gene:	klg / 42707	FlyBaseID:	FBgn0017590	Length:	545	Species:	Drosophila melanogaster

Alignment Length:	475	Identity:	117/475 - (24%)
Similarity:	186/475 - (39%)	Gaps:	76/475 - (16%)

- Green bases have known domain annotations that are detailed below.

Human   279 AGYYECEAVL-----RSSSVPSVVRGAY-LSVLEP--PQFVKEPERHITAEMEKVVDIPCQAKGV 335
            :|.:..||.:     .|.|:.:|.:.|. .|.|..  |:|:.....:.....:.:| :|||.:.:
  Fly    64 SGGFAVEAAISNRGSNSRSMSNVQQSAVAASTLTATLPRFLSRGHTYRAVVGDTLV-LPCQVENL 127

Human   336 PPPSITWYKDAAVVEVEKLTRFRQRN----DG-GLQISGLVPDDTGMFQCFARNAAG--EVQTST 393
            ....:.|.:...|:....:...|...    || .|:||.|.|.|.|.:.|...:...  :|.|..
  Fly   128 GNFVLLWRRGTNVLTASNIMVTRDERVRLIDGYNLEISDLEPQDAGDYVCQISDKINRDQVHTVE 192

Human   394 YLAVTSIAPNITRGPLDSTVIDGMSVVLACETSGAPRPAITWQKGERILASGSVQLPRFTPLESG 458
            .|...|:....|.|.|.:.  .|..:.|.|:.||.|.|:|.|.|     .||:.:  ....:..|
  Fly   193 ILVPPSVRAIPTSGQLQAR--KGGPITLECKGSGNPVPSIYWTK-----KSGANK--STARIGDG 248

Human   459 SLL-ISPTHISDAGTYTCLATNSRGVDEASADLVVWARTRITKPPQ---DQSVI---KGTQASMV 516
            .:| :.......||.|.|.|.|..| |..:.|:    |..:..||.   ::|.|   :|.:|.:|
  Fly   249 PILTLEKLERQQAGVYQCTADNGVG-DPVTVDM----RLDVLYPPDIQVEKSWIHSGEGFEAKLV 308

Human   517 CGVTHDPRVTIRY------IWEKDGATLGTESHPRIRLDRNGSLHISQTWSGDIGTYTCRVISAG 575
            |.|..||..|:.:      |...|...:.|.::..:...|    ||.|.   |.|.|:|...::.
  Fly   309 CIVFADPVATVSWYQNSFPIQSTDRRIMATRANRHMLTIR----HIQQE---DFGNYSCVADNSL 366

Human   576 GNDSRSAHLRVRQLPHAPE--HPVATLSTVERRAINLTWTKPFDGNSPL--IRYI---LEMSEN- 632
            |...:...|..|  |.|.|  .|....|.   .:.||||  ..|...||  :|.:   ::|:|.
  Fly   367 GRSRKYMELSGR--PGAAEFYSPKWGRSP---DSYNLTW--KIDSYPPLEEVRLLYRRVQMNETY 424

Human   633 NAP--WTVLLASVDPKAT--------SVTVKGLVPARSYQFRLCAVNDVGKGQFSKDTERVSLPE 687
            ..|  |...:.:.:.:..        |.|:|.|.|...|:..:.|.|..|..:.|...:.|....
  Fly   425 QQPGRWHDFILTPEHRPASEPLTHIMSYTIKNLHPGGYYEAIVQAKNRYGWNEVSDIFQFVVATN 489

Human   688 EPPTAPPQ-NVIASGRTNQS 706
            .....|.. .|:||.::..:
  Fly   490 SQDIGPEDAEVVASSKSRSN 509

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
SDK2	NP_001138424.1	Ig	27..109	CDD:299845
		IG_like	40..109	CDD:214653
		I-set	120..203	CDD:254352
		Ig	132..210	CDD:299845
		IG_like	222..304	CDD:214653	7/30 (23%)
		IGc2	233..286	CDD:197706	1/6 (17%)
		I-set	308..397	CDD:254352	22/95 (23%)
		Ig	326..394	CDD:143165	19/74 (26%)
		I-set	402..492	CDD:254352	26/90 (29%)
		Ig	416..492	CDD:299845	23/76 (30%)
		Ig	502..586	CDD:299845	24/95 (25%)
		IG_like	502..586	CDD:214653	24/95 (25%)
		FN3	590..681	CDD:238020	27/108 (25%)
		FN3	693..786	CDD:238020	4/15 (27%)
		FN3	794..890	CDD:238020
		FN3	895..983	CDD:238020
		FN3	993..1087	CDD:238020
		FN3	1099..1194	CDD:238020
		FN3	1201..1290	CDD:238020
		FN3	1301..1394	CDD:238020
		FN3	1400..1484	CDD:238020
		FN3	1503..1616	CDD:238020
		FN3	1626..1719	CDD:238020
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1707..1729
		FN3	1724..1805	CDD:238020
		FN3	1837..1916	CDD:238020
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	2039..2067
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	2098..2172
		PDZ-binding. /evidence=ECO:0000250\|UniProtKB:Q6V4S5	2166..2172
klg	NP_524454.2	DUF1370	63..>124	CDD:284518	14/60 (23%)
		IG_like	109..195	CDD:214653	19/86 (22%)
		Ig	118..191	CDD:143165	18/73 (25%)
		IG_like	205..274	CDD:214653	23/78 (29%)
		IGc2	213..273	CDD:197706	20/66 (30%)
		IGc2	301..367	CDD:197706	19/72 (26%)
		FN3	392..486	CDD:238020	23/98 (23%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3510
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810