DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment SDK2 and Dscam3

DIOPT Version :9

Sequence 1:NP_001138424.1 Gene:SDK2 / 54549 HGNCID:19308 Length:2172 Species:Homo sapiens
Sequence 2:NP_996226.2 Gene:Dscam3 / 42103 FlyBaseID:FBgn0261046 Length:2087 Species:Drosophila melanogaster


Alignment Length:1935 Identity:421/1935 - (21%)
Similarity:681/1935 - (35%) Gaps:547/1935 - (28%)


- Green bases have known domain annotations that are detailed below.


Human     7 WTLLALHQIRAARAQD--DVSPYFKTEPV-RTQVHLEGNRLVLTCMAEGSWPLEFKWLHN----- 63
            |...|.:|....|.:.  .|:.|.....: :.|:...|......|...||......||||     
  Fly   318 WICQASNQFGEQRIEIRLSVNSYVSVHILPQVQIVNSGGTANFNCTTTGSAIDAIDWLHNGKPLQ 382

Human    64 -NRELT------KFSLEYRYMITSLDRTHAGFYRCIVRNR------MGALLQRQTEVQVAYMGSF 115
             |..||      :|..:...::.::.|...|.|:|:|.|:      |..|....|..::.|  :|
  Fly   383 ANNALTTGRDNIRFLSKSSLLVQNVGRRDRGVYQCLVENQRASAQAMAELKLGDTVPELIY--TF 445

Human   116 EEGEKHQSVSHGEAAVIRAPRIASFPQPQVTWFRDGRKIPPSSRIAITLENTLVI---------- 170
            .|    |:|..|....::.....| |.||..|..|.:.|     :.::|.:...|          
  Fly   446 IE----QNVRPGPLISLKCSASGS-PPPQFAWLLDSQPI-----MDVSLHHRFAIGQFVDMSGDV 500

Human   171 -----LSTVAPDAGRYYVQAVNDKNGDNKTSQPITLTVENVGGPADPIAPTI--IIPPKNTSVVA 228
                 :|.|.||.|..|....::..|..:.|..:     ||.||     |.:  |.|.|   .||
  Fly   501 ISHLNISHVRPDDGGLYKCVASNSMGSVQHSARL-----NVYGP-----PYVRAIGPIK---AVA 552

Human   229 GTSEVTLECVANARPLIKLHIIWKKDGVLLSGGISDH--------NRRLTIPN-PTGSDAGYYEC 284
            | .::.:.|.....|:.::.  |:|....|:  .|:|        ..:|.|.| ..|.|.|.|.|
  Fly   553 G-EDIIVHCPFAGYPVEQIR--WEKAHQELT--TSNHYELASVADGGQLVIKNVEPGRDQGIYTC 612

Human   285 EAVLRSSSVPSVVRGAYLSVLEPP-----QFVKEPERHITAEMEKVVDIPCQAKGVPPPSITWYK 344
              ::||.:.....|...|:|..||     :|.|..:....|::...|     :.|..|...:|.|
  Fly   613 --IVRSRAGEEARRDMQLNVNSPPVIEPFKFPKNLQEGGRAQITCAV-----SSGDMPIYFSWKK 670

Human   345 -DAAVVEVEKLTRFRQRNDGGLQISGLVPDDTGMFQCFARNAAGEVQTSTYLAVTSIAPNITRGP 408
             |:::....::|..::.....|....:....:|.:.|:|.|||.:|..:..|.| .:||.....|
  Fly   671 DDSSIPSSLQITEKKEEFYSLLVFKDISARHSGKYTCYASNAAAKVNYTAELQV-RVAPRWRYEP 734

Human   409 LDSTVIDGMSVVLACETSGAPRPAITWQKGERILASGSVQLPRFTPL--ESGSLLISPTHISDAG 471
            :|:.::.|.::.:.||..|.|.|.|||.||:   ..||..   |.||  .:.|||::....:|.|
  Fly   735 MDTAIMLGNTISINCEAEGYPIPTITWFKGQ---GKGSKD---FKPLSMRNHSLLLNLATDNDEG 793

Human   472 TYTCLATNSRGVDEASADLVVWARTRITKPPQ-DQSV-----IKGTQASMVCGVTHDPRVTIRYI 530
            .|.|.|||     |..|.|....|..:.:|.: :||.     .:....::.|....|..:||.: 
  Fly   794 YYMCQATN-----EIGAGLKKTIRINVNEPARFEQSARNISSRRNDPVTLDCHAKGDEPITIGW- 852

Human   531 WEKDGATLGTESHPRIRLDR--------------NGSLHISQTWSGDIGTYTCRVISAGGNDSRS 581
                     |:::.||.|:.              :..|.|..:...|.|.|.|...:..|...:.
  Fly   853 ---------TQNNGRIDLNNFRFSIAEMKTEKGVDSQLTIGHSDRHDSGVYRCIAENPYGRAEQI 908

Human   582 AHLRVRQLPHAPEHPVATLSTVERRAINLTWTKPFDGNSPLIRYILE------------MSENNA 634
            ..|.|::.|..|.|  ..:..|..|.:.|:|.:|||||||::.|:::            ::....
  Fly   909 IFLAVQERPDTPSH--LEIFEVGSRTVKLSWRRPFDGNSPVLSYLVQYQALKYLQSHGSLAAAGG 971

Human   635 PWTVLLASVDPKATSVT------------VKGLVPARSYQFRLCAVNDVGKGQFSKDTERVSL-- 685
            .|...:.:|...:||::            |.||.||.::..|:.|:|::.:..:   ||.:.|  
  Fly   972 DWNGHVINVSLPSTSISRSYDSDLRESAIVAGLTPATTFLIRMQAINEIERSAY---TEAIVLKT 1033

Human   686 PEEPPTAPPQNVIASGRTNQSIMIQWQPPPESHQNGILKGYIIRYCLAGLPVGYQFKNITDADVN 750
            .||.||..|.||.........:::.||.||....||.|.||.:. |      ..:.:||....|.
  Fly  1034 QEEAPTEAPSNVQVQTGGESELIVTWQIPPRESWNGELIGYTVN-C------SEEKQNINFISVV 1091

Human   751 NLLLEDLII---------------WTNYEIEVAAYNSAGLGVYSSKVTEWTLQGVPTVPPGNVHA 800
            |..|:..|:               ::.|.:.:.|.||.|.|.:|:.:...|.:|||...|.||:.
  Fly  1092 NSSLKSTIVSGWATTKATLRGLRKYSRYAVTIRAMNSFGSGPWSAAIFGTTAEGVPEAAPQNVNC 1156

Human   801 EATNSTTIRFTWNAPSPQFINGINQGYKLIAWEPEQEE-------EVTMVTARPNFQDSIHVGFV 858
            .|.:|.:::.:|..|..||..||.||||:: :.|...:       |:...:   |.:..:|.   
  Fly  1157 TALSSQSLKISWLEPPLQFHGGIIQGYKIL-YRPIVHQIDFPAKLEIKRTS---NLETYLHT--- 1214

Human   859 SGLKKFTEYFTSVLCFTTPGDGPRSTPQLVRTHEDVPGPVGHLSFSEILDTSLKVSWQEPGEKNG 923
              |.|.:.|...||.:|..|||..|.|...:|.:|||.....:..:.:...|:.:||..|..:||
  Fly  1215 --LHKASNYSIRVLAYTATGDGLASHPLFCQTDDDVPDAPAAIKAAALTADSILISWLTPKNRNG 1277

Human   924 ILTGYRISWEEYNRTNTRVTHYL-------PNVTLEYRVTGLTALTTYTIEVAAMTSKGQGQVSA 981
            |::.|.:...|..|.....||.:       | ||.|.|  .|.....|...|:|.||        
  Fly  1278 IISHYTVYSREAGRKGQAKTHMVRVDENGYP-VTFESR--SLAENQMYEFWVSASTS-------- 1331

Human   982 STISSGVPPELPGPPTNLGISNIGPRSVTLQFRPGYDGKTSISRWLVEAQVGVVGEGEEWLLIHQ 1046
                                                                 |||||...:|.|
  Fly  1332 -----------------------------------------------------VGEGEPTSVIAQ 1343

Human  1047 LSNEPDARSMEVPDLNPFTCYSFRMRQVNIVGTSPPSQPSRKIQTLQAPPDMAPANVSLRTASET 1111
            .:|                                          .:||..:|.....:|.|..|
  Fly  1344 ATN------------------------------------------TRAPARIASFGQVVRKAVGT 1366

Human  1112 SLWLRWM----PLPEMEYNGNPESVGYKIKYSRSDGHGKTLSHVVQDRVERDYTIEDLEEWTEYR 1172
            .|.|..:    |.|...:......|.:...|..:: .|....|.|:..:..:||           
  Fly  1367 GLVLECLAVGNPTPRARWLTRDRPVTFSPFYEVTN-EGNLKIHRVEGSLSGNYT----------- 1419

Human  1173 VQVQAFNAIGSGPWSQTVVGRTRESVPSSGPTNVSALATTSSSMLVRWSEVPEADRNGLVLGYKV 1237
              ..|.|..||.                                                   ::
  Fly  1420 --CTANNLFGSD---------------------------------------------------EI 1431

Human  1238 MYKEKDSDTQPRFWLVEGNSSRSAQLTGLGKYVLYEVQVLAFTRIGDGSPSHPPILERTLDDVPG 1302
            .|                                   ||:|..     .||.|.|:.:       
  Fly  1432 QY-----------------------------------QVIAMK-----PPSAPQIIVQ------- 1449

Human  1303 PPMGILFPEVRTTSVRLIWQPPAAPNGIILAYQITHRLNTTTANTATVEVLAPSARQYTATGLKP 1367
                    .....|:|:.|..|......:..|.|::.   |...:.::..|.|....:|.:|||.
  Fly  1450 --------YASADSIRVSWDAPDDGGAPLQGYTISYH---TAGESWSITELLPENNAFTISGLKC 1503

Human  1368 ESVYLFRITAQTRKGWGEAAEALVVTTEKRDRPQPPSRPMVQQEDVRARSVLLSWEPGSDGLSPV 1432
            .:.|:.:::|....|.|.|:|.:.|.|:.:....|.:..::..........|.||:.|  |.| :
  Fly  1504 GNQYIIKMSAHNMVGSGVASEEINVWTKGKASQAPNANELIATNATCVNLKLSSWQNG--GCS-I 1565

Human  1433 RYYTIQTRELPSGRWALHSASVSH---NASSFIVDRLKPFTSYKFRVKATNDIGDSEFSEESE-S 1493
            .:::|:.|.|...||.:.::.:|:   |..:.|.....|...|:.|:.||||.|.:  :|... |
  Fly  1566 HHFSIEHRPLGDIRWTVVTSDISNAEENRENLIFCDFLPAKWYQLRISATNDAGKT--TEHYHFS 1628

Human  1494 LTTLQAAPDEAPTILSVTPHTTTSVLIRWQPPAED-----------KINGILLGFRIRYRELL-- 1545
            .|.:.......|::.........:::....|.:.|           .::.|.:...|::|..|  
  Fly  1629 TTNIDGITIPPPSVFPSENDLMNNLINSTNPTSGDWFATLIVVVIITVSIITIALTIKHRRTLCG 1693

Human  1546 --YEGLRGFTLRGINNPGATWAELTSMYSMRNLSRPSLTQYELDNLNKHRRYEIRMSVYNAVGEG 1608
              .||....||.|                          .|:.|:.|:..:.....|....|.:|
  Fly  1694 PIAEGYESRTLPG--------------------------DYKEDHENRRNQQVYSASPVKTVDKG 1732

Human  1609 PSS-----PPQEVFVGEAVPTAAPRNVVVHGATA-TQLDVTWE------PPPLDSQNGDIQGYKI 1661
            ..|     .|...|......|.||.........| |.||.|.:      |   :.:|.:...|.:
  Fly  1733 NESEMYEISPYATFSVNGGRTGAPAKTPTRAVAAQTPLDYTMQFKTFGHP---EGENLNATAYPL 1794

Human  1662 Y------------FWEAQRGNLTERVKTLFLAENSVKLKNLTGYTAYMVSVAAFNAAGDGPRSTP 1714
            .            .|..||...||...||        .|::|        :.|.:.||...:|  
  Fly  1795 LPSSGFGHVKSKSSWHKQRYYNTEDESTL--------SKSMT--------IVAGSQAGHSKKS-- 1841

Human  1715 TQGQTQQAAPSAPSSVKFSELTTTSVNVSWEAPQFPNGILEGYRLVYEPC 1764
            ..|::.:::.:....|..|| :.||::.|.|....|.     ||:   ||
  Fly  1842 NGGRSAKSSAACSGVVAGSE-SDTSISPSTEFSNMPT-----YRV---PC 1882

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
SDK2NP_001138424.1 Ig 27..109 CDD:299845 23/100 (23%)
IG_like 40..109 CDD:214653 21/86 (24%)
I-set 120..203 CDD:254352 20/97 (21%)
Ig 132..210 CDD:299845 20/92 (22%)
IG_like 222..304 CDD:214653 23/90 (26%)
IGc2 233..286 CDD:197706 15/61 (25%)
I-set 308..397 CDD:254352 20/94 (21%)
Ig 326..394 CDD:143165 15/68 (22%)
I-set 402..492 CDD:254352 32/91 (35%)
Ig 416..492 CDD:299845 29/77 (38%)
Ig 502..586 CDD:299845 18/103 (17%)
IG_like 502..586 CDD:214653 18/103 (17%)
FN3 590..681 CDD:238020 27/114 (24%)
FN3 693..786 CDD:238020 26/107 (24%)
FN3 794..890 CDD:238020 30/102 (29%)
FN3 895..983 CDD:238020 24/94 (26%)
FN3 993..1087 CDD:238020 8/93 (9%)
FN3 1099..1194 CDD:238020 19/98 (19%)
FN3 1201..1290 CDD:238020 6/88 (7%)
FN3 1301..1394 CDD:238020 20/92 (22%)
FN3 1400..1484 CDD:238020 22/86 (26%)
FN3 1503..1616 CDD:238020 20/132 (15%)
FN3 1626..1719 CDD:238020 24/111 (22%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1707..1729 3/21 (14%)
FN3 1724..1805 CDD:238020 12/41 (29%)
FN3 1837..1916 CDD:238020
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 2039..2067
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 2098..2172
PDZ-binding. /evidence=ECO:0000250|UniProtKB:Q6V4S5 2166..2172
Dscam3NP_996226.2 IG 56..133 CDD:214652
Ig 56..125 CDD:143165
I-set 246..337 CDD:254352 4/18 (22%)
Ig 264..334 CDD:143165 4/15 (27%)
I-set 345..433 CDD:254352 20/87 (23%)
Ig 358..431 CDD:143165 18/72 (25%)
Ig 456..533 CDD:143165 17/82 (21%)
IGc2 553..619 CDD:197706 18/72 (25%)
I-set 634..724 CDD:254352 20/94 (21%)
ig 645..712 CDD:278476 12/71 (17%)
IG_like 734..815 CDD:214653 32/91 (35%)
Ig 745..815 CDD:299845 29/80 (36%)
I-set 820..913 CDD:254352 18/102 (18%)
Ig 838..920 CDD:299845 18/91 (20%)
FN3 917..1033 CDD:238020 30/120 (25%)
FN3 1040..1142 CDD:238020 26/108 (24%)
fn3 1150..1237 CDD:278470 28/95 (29%)
FN3 1263..1345 CDD:238020 30/145 (21%)
Ig 1350..1436 CDD:299845 22/185 (12%)
IG_like 1358..1436 CDD:214653 20/177 (11%)
FN3 1441..1530 CDD:238020 24/106 (23%)
FN3 1542..1620 CDD:238020 21/80 (26%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG3510
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.810

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