DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment SDK2 and dpr17

DIOPT Version :9

Sequence 1:	NP_001138424.1	Gene:	SDK2 / 54549	HGNCID:	19308	Length:	2172	Species:	Homo sapiens
Sequence 2:	NP_001287297.1	Gene:	dpr17 / 41470	FlyBaseID:	FBgn0051361	Length:	664	Species:	Drosophila melanogaster

Alignment Length:	473	Identity:	98/473 - (20%)
Similarity:	157/473 - (33%)	Gaps:	155/473 - (32%)

- Green bases have known domain annotations that are detailed below.

Human   103 RQTEVQVAYMGSFEEGEKHQSVSHGEAAVIRAPRIASFPQPQVTWFRDGRKIPPSSRIAITLENT 167
            ||||.|.|            |.:...||...|...|:.                :|..|.|....
  Fly   239 RQTEAQTA------------STATQAAAATSAATSAAI----------------ASAAAATETAA 275

Human   168 LVILSTVAPDAGRYYVQAVNDKNGDNKTSQPITLTVENVGGPADPIA-----------------P 215
            .:::||:.|.:                |...:..::|.|.|....:|                 |
  Fly   276 EMLISTIYPAS----------------TETDLHNSIERVEGQRGKMANAFHPGVPDSLTKGFSIP 324

Human   216 TIIIPP------------KNTSVVAGTSEVTLECVANARPLIKLHIIWKKDGVLLSGGISDHNRR 268
            | .:||            :..:..|..:::..|..|.|.....     ..:.|.:|   .:..||
  Fly   325 T-FLPPFPVFAAADLPAYRAAADAAEAAKLAAEAAAQAAAAKT-----SSEAVTMS---PEEQRR 380

Human   269 ---------LTIPNPTGSDAGYYECEAVLRSSSVPSVVRGAYLSVLEPPQFVKEPERHITAEMEK 324
                     |......|..||    .||.|:.::|.:                    :|||:|..
  Fly   381 QMFNEQHSYLAAHRDGGDGAG----SAVRRNLTMPVL--------------------NITAQMGN 421

Human   325 VVDIPCQAKGVPPPSITW--YKDAAVVEVEKLT-----RF----RQRND--GGLQISGLVPDDTG 376
            ...:|||...:....::|  .:|..::.|::.|     ||    ::.:|  ..|||..:.|.|.|
  Fly   422 HAYMPCQIHRLSDKPVSWVRMRDNHIISVDETTFIADERFQSIYQEDHDYTWSLQIKYVEPSDAG 486

Human   377 MFQCFARNAAGEVQTSTYLAVTSIAPNITR-GPLDSTVIDGMSVVLACETSGA--PRPAITWQKG 438
            .::|   ..|.|.:.|..:.:..:.|.... |.....|..|..|.|.|...|.  |...|.|.:|
  Fly   487 WYEC---QMATEPKLSAKVHLQIVKPKTELIGDQSRFVKAGSKVALHCIVRGTLDPPKYIIWFRG 548

Human   439 ERILASGSVQLPRFTPLES-------------GSLLISPTHISDAGTYTCLATNSRGVD------ 484
            ::.::....:...:|.|:.             |||:|......|:|.|||..:||..|.
  Fly   549 QKKISDSDERTGWYTQLDRNIFGTVGDNQNTIGSLIIPLVRKEDSGNYTCQPSNSVSVSVDLHVL 613

Human   485 --EASADLVVWARTRITK 500
              |.||..::....|.||
  Fly   614 SGEYSASAIMSTAARTTK 631

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
SDK2	NP_001138424.1	Ig	27..109	CDD:299845	4/5 (80%)
		IG_like	40..109	CDD:214653	4/5 (80%)
		I-set	120..203	CDD:254352	12/82 (15%)
		Ig	132..210	CDD:299845	12/77 (16%)
		IG_like	222..304	CDD:214653	16/90 (18%)
		IGc2	233..286	CDD:197706	11/61 (18%)
		I-set	308..397	CDD:254352	24/101 (24%)
		Ig	326..394	CDD:143165	20/80 (25%)
		I-set	402..492	CDD:254352	29/113 (26%)
		Ig	416..492	CDD:299845	26/98 (27%)
		Ig	502..586	CDD:299845
		IG_like	502..586	CDD:214653
		FN3	590..681	CDD:238020
		FN3	693..786	CDD:238020
		FN3	794..890	CDD:238020
		FN3	895..983	CDD:238020
		FN3	993..1087	CDD:238020
		FN3	1099..1194	CDD:238020
		FN3	1201..1290	CDD:238020
		FN3	1301..1394	CDD:238020
		FN3	1400..1484	CDD:238020
		FN3	1503..1616	CDD:238020
		FN3	1626..1719	CDD:238020
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1707..1729
		FN3	1724..1805	CDD:238020
		FN3	1837..1916	CDD:238020
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	2039..2067
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	2098..2172
		PDZ-binding. /evidence=ECO:0000250\|UniProtKB:Q6V4S5	2166..2172
dpr17	NP_001287297.1	IG_like	414..491	CDD:214653	21/79 (27%)
		Ig	415..507	CDD:299845	24/94 (26%)
		IG_like	521..612	CDD:214653	24/90 (27%)
		IGc2	524..605	CDD:197706	22/80 (28%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3510
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810