DRSC/TRiP Functional Genomics Resources

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Protein Alignment SDK2 and dpr11

DIOPT Version :9

Sequence 1:NP_001138424.1 Gene:SDK2 / 54549 HGNCID:19308 Length:2172 Species:Homo sapiens
Sequence 2:NP_001262320.1 Gene:dpr11 / 40800 FlyBaseID:FBgn0053202 Length:360 Species:Drosophila melanogaster


Alignment Length:344 Identity:85/344 - (24%)
Similarity:128/344 - (37%) Gaps:78/344 - (22%)


- Green bases have known domain annotations that are detailed below.


Human   222 KNTSVVAGTSEV-TLECVANARPLIKLHIIWKKDGVLLSGGISDHNR--------RLTIPNPTGS 277
            ||.|    .||: |||  ...|||....:.....|.:|...|:.|.:        |::.|. .|:
  Fly     5 KNRS----RSEMQTLE--TRVRPLQGAQLTQLLLGGILCLTIASHTQTSAEAAGGRVSGPG-AGT 62

Human   278 DAGYYECEAVLRSSSVPSVVRG------AYLSVLEPPQFVKEPE------------------RHI 318
            ..|.....|...|:::.|...|      |:.|:.:....:.|..                  .::
  Fly    63 SEGAGTSSASAASTAISSDESGDPSSATAFSSLAQVSSLLPEASALSATSGLVEPYLDGYATSNV 127

Human   319 TAEMEKVVDIPCQAKGVPPPSITW--YKDAAVVEVEKLT-----RF---RQRND-GGLQISGLVP 372
            |.::.....:||:.|.:...|::|  .:|..::.|::..     ||   :|.:. ..|||..:..
  Fly   128 TTQIGTHAYLPCRVKQLGNKSVSWIRLRDGHILTVDRAVFIADQRFLAIKQPDKYWTLQIKYVQA 192

Human   373 DDTGMFQCFARNAAGEVQTSTYLAVTSIAPNI-TRGPLDSTVIDGMSVVLACETSGAPRPA--IT 434
            .|.|.::|   ..:.|.:.|..:.:..:.|.. ..|..|..|..|.:|||.|...||..|.  |.
  Fly   193 RDAGSYEC---QVSTEPKVSARVQLQVVVPRTEILGEPDRYVKAGSNVVLRCIVRGALEPPTFIM 254

Human   435 WQKGERILASGS----VQLPRFTPLES-------GSLLISPTHISDAGTYTCLATNS-------- 480
            |..|...||:.|    .||....|..|       |||:|......|.|.|||..:||        
  Fly   255 WYHGAEQLAADSRRHRTQLDPNLPEASGEGQSTIGSLIIESAKKRDTGNYTCSPSNSPSATVTLN 319

Human   481 --RGVDEASADLVVWARTR 497
              .|...|||.....|.||
  Fly   320 IINGESSASAVTSSAATTR 338

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
SDK2NP_001138424.1 Ig 27..109 CDD:299845
IG_like 40..109 CDD:214653
I-set 120..203 CDD:254352
Ig 132..210 CDD:299845
IG_like 222..304 CDD:214653 24/96 (25%)
IGc2 233..286 CDD:197706 14/61 (23%)
I-set 308..397 CDD:254352 20/117 (17%)
Ig 326..394 CDD:143165 18/78 (23%)
I-set 402..492 CDD:254352 37/113 (33%)
Ig 416..492 CDD:299845 33/98 (34%)
Ig 502..586 CDD:299845
IG_like 502..586 CDD:214653
FN3 590..681 CDD:238020
FN3 693..786 CDD:238020
FN3 794..890 CDD:238020
FN3 895..983 CDD:238020
FN3 993..1087 CDD:238020
FN3 1099..1194 CDD:238020
FN3 1201..1290 CDD:238020
FN3 1301..1394 CDD:238020
FN3 1400..1484 CDD:238020
FN3 1503..1616 CDD:238020
FN3 1626..1719 CDD:238020
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1707..1729
FN3 1724..1805 CDD:238020
FN3 1837..1916 CDD:238020
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 2039..2067
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 2098..2172
PDZ-binding. /evidence=ECO:0000250|UniProtKB:Q6V4S5 2166..2172
dpr11NP_001262320.1 I-set 125..216 CDD:254352 19/93 (20%)
Ig 127..217 CDD:299845 19/92 (21%)
IG_like 227..320 CDD:214653 31/92 (34%)
IGc2 234..311 CDD:197706 27/76 (36%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG3510
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.810

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