DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment SDK2 and CG7166

DIOPT Version :9

Sequence 1:	NP_001138424.1	Gene:	SDK2 / 54549	HGNCID:	19308	Length:	2172	Species:	Homo sapiens
Sequence 2:	NP_001262181.1	Gene:	CG7166 / 40401	FlyBaseID:	FBgn0037107	Length:	467	Species:	Drosophila melanogaster

Alignment Length:	447	Identity:	114/447 - (25%)
Similarity:	174/447 - (38%)	Gaps:	89/447 - (19%)

- Green bases have known domain annotations that are detailed below.

Human   281 YYECEAVLRSSSVPSVVRGAY-LSVLEPPQFVKEPERHITAEMEKV-----VDIPCQAKGVPPPS 339
            |:.....|.|.|: |::.|:: |...:||  ...|:......:.||     :::||:.:.:....
  Fly     8 YWTLVLYLFSFSL-SLIGGSFILPENDPP--TTAPKFLSRGHLYKVIVGETIELPCKVQNLGSFV 69

Human   340 ITWYKDAAV-----VEVEKLTRFRQRNDGGLQISGLVPDDTGMFQCFARNAAGEVQTSTYLAVTS 399
            :.|.|.::|     :::.:..||:...|..|||:|:...|.|.:.|...:.....|..|...:
  Fly    70 LLWRKGSSVLTAGHLKITRDQRFKIVGDYNLQINGVKTQDAGDYICQLGDQENRDQVHTVEIL-- 132

Human   400 IAPNITRGPLDS--TVIDGMSVVLACETSGAPRPAITWQKGERILASGSVQLPRFTPLESGSLLI 462
            :.|.:...|.:.  |...|.:|.|.|:.||.|.|.|.|.|.:  :.||
  Fly   133 VPPTLRALPHNGQVTARKGSTVTLECKASGNPVPTIFWFKKD--VFSG----------------- 178

Human   463 SPTHISD-------------AGTYTCLATNSRGV-DEASADLVVWARTRITKPPQ---DQSVI-- 508
             |||:||             ||||.|.|.|  || |..|.|:    :..|..||:   ::|.:
  Fly   179 -PTHLSDSSTLILENVDRHHAGTYQCSADN--GVKDRVSMDI----QLTILSPPEITVEKSWVHA 236

Human   509 -KGTQASMVCGVTHDPRVTIRYIWEKDG----ATLGTESHPRIRLDRNGSLHISQTWSGDIGTYT 568
             :|....:||.|..|  |....:|.::.    ||.....:||   |...||.|......|.|.|:
  Fly   237 SEGYDVELVCIVHGD--VNSEMLWYQNSFLLDATDRRSMYPR---DDRYSLIIRNFQPTDFGNYS 296

Human   569 CRVISAGGNDSRSAHLRVRQLPHAPEHPVATLSTVERRAINLTWT----KPFDGNSPLIRYIL-- 627
            |...:|.|...:  ::.|...|...:.....||..... .|||||    .|.|....|.|.:|
  Fly   297 CVADNALGRTKK--YIEVSGRPGPADFISPALSGFLDH-YNLTWTIESIPPLDEIKLLYRRLLMN 358

Human   628 EMSENNAPWTVLLASVDPKAT-------SVTVKGLVPARSYQFRLCAVNDVGKGQFS 677
            |..::...|........|..|       |..||.|.....|:..:.|.|..|..:.|
  Fly   359 ETYQHPGKWHEYHIKPTPIRTDGSHFLMSYLVKNLEHNAVYEAIVQAKNKYGWNEIS 415

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
SDK2	NP_001138424.1	Ig	27..109	CDD:299845
		IG_like	40..109	CDD:214653
		I-set	120..203	CDD:254352
		Ig	132..210	CDD:299845
		IG_like	222..304	CDD:214653	7/23 (30%)
		IGc2	233..286	CDD:197706	1/4 (25%)
		I-set	308..397	CDD:254352	21/98 (21%)
		Ig	326..394	CDD:143165	16/72 (22%)
		I-set	402..492	CDD:254352	33/105 (31%)
		Ig	416..492	CDD:299845	30/89 (34%)
		Ig	502..586	CDD:299845	23/93 (25%)
		IG_like	502..586	CDD:214653	23/93 (25%)
		FN3	590..681	CDD:238020	26/101 (26%)
		FN3	693..786	CDD:238020
		FN3	794..890	CDD:238020
		FN3	895..983	CDD:238020
		FN3	993..1087	CDD:238020
		FN3	1099..1194	CDD:238020
		FN3	1201..1290	CDD:238020
		FN3	1301..1394	CDD:238020
		FN3	1400..1484	CDD:238020
		FN3	1503..1616	CDD:238020
		FN3	1626..1719	CDD:238020
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1707..1729
		FN3	1724..1805	CDD:238020
		FN3	1837..1916	CDD:238020
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	2039..2067
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	2098..2172
		PDZ-binding. /evidence=ECO:0000250\|UniProtKB:Q6V4S5	2166..2172
CG7166	NP_001262181.1	IG_like	50..133	CDD:214653	18/84 (21%)
		Ig	56..116	CDD:143165	14/59 (24%)
		IG_like	144..221	CDD:214653	31/102 (30%)
		IGc2	151..209	CDD:197706	25/79 (32%)
		IG_like	232..313	CDD:214653	22/87 (25%)
		Ig	242..311	CDD:143165	20/75 (27%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3510
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810