DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment SDK2 and Ptp69D

DIOPT Version :9

Sequence 1:	NP_001138424.1	Gene:	SDK2 / 54549	HGNCID:	19308	Length:	2172	Species:	Homo sapiens
Sequence 2:	NP_524048.2	Gene:	Ptp69D / 39443	FlyBaseID:	FBgn0014007	Length:	1462	Species:	Drosophila melanogaster

Alignment Length:	643	Identity:	155/643 - (24%)
Similarity:	245/643 - (38%)	Gaps:	136/643 - (21%)

- Green bases have known domain annotations that are detailed below.

Human   416 GMSVVLACETSGAPRPAITWQKGERILASGSVQLP-RFTPLES---GS--------------LLI 462
            |.:|.|.|   .:...|:.|:.|.:.:.....:.. |..||:|   ||              |.:
  Fly    38 GKNVSLEC---ASENEAVAWKLGNQTINKNHTRYKIRTEPLKSNDDGSENNDSQDFIKYKNVLAL 99

Human   463 SPTHISDAGTYTCLATNSRGVDEASADLVV--WARTRITKPPQDQSVIKGTQASMV-CGVTHDPR 524
            ...:|.|:|.|||.|...:   ..|.:..|  :..:::.:...|:...|..|..|: |.:...|:
  Fly   100 LDVNIKDSGNYTCTAQTGQ---NHSTEFQVRPYLPSKVLQSTPDRIKRKIKQDVMLYCLIEMYPQ 161

Human   525 --VTIRYI-WEKDGAT---LGT--------ESHPRIRLDRNGSLHISQTWSGDIGTYTCRVISAG 575
              .|.|.: |.|||:.   |.|        ::|      .|.:|..::.:..:.|||.|.|....
  Fly   162 NETTNRNLKWLKDGSQFEFLDTFSSISKLNDTH------LNFTLEFTEVYKKENGTYKCTVFDDT 220

Human   576 GND--SRSAHLRVRQLPHAPEHPVATLSTVERRAINLTWTKPFDGNSPLIRYILEMSENNAP-WT 637
            |.:  |:...|.|.::|..   .:.....|....|.|.||.. |||.|:.::.:.:.|...| :|
  Fly   221 GLEITSKEITLFVMEVPQV---SIDFAKAVGANKIYLNWTVN-DGNDPIQKFFITLQEAGTPTFT 281

Human   638 VLLASVDPKATSVTVKGLVPARSYQFRLCAVNDVGKGQFSKDTERVSLPEEPPTAPPQNVIASGR 702
            .....::...||..:....|..:|..|:...|.:|.||.::..:.::.....|...|: |..:|.
  Fly   282 YHKDFINGSHTSYILDHFKPNTTYFLRIVGKNSIGNGQPTQYPQGITTLSYDPIFIPK-VETTGS 345

Human   703 TNQSIMIQWQPPPESHQNGILKGYIIRYCLAGLPVGYQFKNITDA----DVNNL--LLEDLIIWT 761
            |..:|.|.|.|||..     |..||..|.|.....|...|.|.:|    :..||  :.:.|...|
  Fly   346 TASTITIGWNPPPPD-----LIDYIQYYELIVSESGEVPKVIEEAIYQQNSRNLPYMFDKLKTAT 405

Human   762 NYEIEVAAYN--SAGLGVYSSKVTEWTLQGVPTVPPGNV-----HAEATNSTTIRFTWNAPSPQF 819
            :||..|.|.:  :...|.:|..|...|:.||.| .|.|:     |...|...:|...|:.|...
  Fly   406 DYEFRVRACSDLTKTCGPWSENVNGTTMDGVAT-KPTNLSIQCHHDNVTRGNSIAINWDVPKTP- 468

Human   820 INGINQGYKLI-------------AWEP------EQEEEVTMVTARPNFQDSIHVGFVSGLKKFT 865
             ||....| ||             .|.|      |...:....:..||...::.|..::..||..
  Fly   469 -NGKVVSY-LIHLLGNPMSTVDREMWGPKIRRIDEPHHKTLYESVSPNTNYTVTVSAITRHKKNG 531

Human   866 EYFTSVLCFTTPGDG----PRSTPQLVRTHEDVPGPVGHLSFSEI-LDTS--LKVSWQEPGEKNG 923
            |          |..|    |.|||.          .:|...:|:: ||:.  ||:...:..|:||
  Fly   532 E----------PATGSCLMPVSTPD----------AIGRTMWSKVNLDSKYVLKLYLPKISERNG 576

Human   924 ILTGYRISWEEYNRTNTRVTHYLP-----NVTL--EYRVTGLTALTTYTIEVAAMTSK 974
            .:..||:.....|..|..    ||     |:..  |.....:|..:.|..|:  ::||
  Fly   577 PICCYRLYLVRINNDNKE----LPDPEKLNIATYQEVHSDNVTRSSAYIAEM--ISSK 628

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
SDK2	NP_001138424.1	Ig	27..109	CDD:299845
		IG_like	40..109	CDD:214653
		I-set	120..203	CDD:254352
		Ig	132..210	CDD:299845
		IG_like	222..304	CDD:214653
		IGc2	233..286	CDD:197706
		I-set	308..397	CDD:254352
		Ig	326..394	CDD:143165
		I-set	402..492	CDD:254352	22/93 (24%)
		Ig	416..492	CDD:299845	22/93 (24%)
		Ig	502..586	CDD:299845	25/100 (25%)
		IG_like	502..586	CDD:214653	25/100 (25%)
		FN3	590..681	CDD:238020	22/91 (24%)
		FN3	693..786	CDD:238020	30/100 (30%)
		FN3	794..890	CDD:238020	27/123 (22%)
		FN3	895..983	CDD:238020	22/90 (24%)
		FN3	993..1087	CDD:238020
		FN3	1099..1194	CDD:238020
		FN3	1201..1290	CDD:238020
		FN3	1301..1394	CDD:238020
		FN3	1400..1484	CDD:238020
		FN3	1503..1616	CDD:238020
		FN3	1626..1719	CDD:238020
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1707..1729
		FN3	1724..1805	CDD:238020
		FN3	1837..1916	CDD:238020
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	2039..2067
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	2098..2172
		PDZ-binding. /evidence=ECO:0000250\|UniProtKB:Q6V4S5	2166..2172
Ptp69D	NP_524048.2	IG_like	139..233	CDD:214653	25/99 (25%)
		Ig	150..221	CDD:143165	19/76 (25%)
		fn3	237..321	CDD:278470	22/87 (25%)
		FN3	339..432	CDD:238020	29/98 (30%)
		FN3	439..535	CDD:238020	22/108 (20%)
		PTPc	892..1155	CDD:214550
		PTPc	920..1155	CDD:238006
		PHA02694	<1121..1206	CDD:177476
		PTPc	1186..1449	CDD:214550
		PTPc	1216..1449	CDD:238006
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910