DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment SDK2 and Dscam2

DIOPT Version :9

Sequence 1:NP_001138424.1 Gene:SDK2 / 54549 HGNCID:19308 Length:2172 Species:Homo sapiens
Sequence 2:NP_001261500.1 Gene:Dscam2 / 38788 FlyBaseID:FBgn0265296 Length:2101 Species:Drosophila melanogaster


Alignment Length:1913 Identity:459/1913 - (23%)
Similarity:743/1913 - (38%) Gaps:408/1913 - (21%)


- Green bases have known domain annotations that are detailed below.


Human    17 AARAQDDVSPYFKTEPVRTQVHLEGN---RLVLTCMAEGSWPLEFK---WLHNNREL-TKFSLEY 74
            |...|.::||..      ..||:.|.   |.::|  :.|| |:..:   |..:.|:| :...:|.
  Fly   328 ATPIQVEISPNV------LSVHMGGTAEFRCLVT--SNGS-PVGMQNILWYKDGRQLPSSGRVED 383

Human    75 RYMITSLDRTHAGFYRCIVRNRMGALLQRQTEVQV-----AYMGSFEEGEKHQSVSHGEAAVIRA 134
            ..::..:.|.:.|.|:|:||...|...|...|:|:     ..:.||.|    |::..|.|..::.
  Fly   384 TLVVPRVSRENRGMYQCVVRRPEGDTFQATAELQLGDAPPVLLYSFIE----QTLQPGPAVSLKC 444

Human   135 PRIASFPQPQVTWFRDGRKIPPSSRIA----ITLENTLV----ILSTVAPDAGRYYVQAVNDKNG 191
             ..|..|.||::|..||..:|.:.|..    ||:...::    |...:..|.|.|...|      
  Fly   445 -SAAGNPTPQISWTLDGFPLPSNGRFMIGQYITVHGDVISHVNISHVMVEDGGEYACIA------ 502

Human   192 DNKTSQPITLTVENVGGPADPIAPTIIIPPKNTSVVAGTSEVTLECVANARPLIKLHIIWKKDGV 256
            :|:..:.......|:.|     .|.|.:.||.|:|...|  :.|:|.....|:.::|  |::.|.
  Fly   503 ENRAGRVQHAARLNIYG-----LPYIRLIPKVTAVSGET--LNLKCPVAGYPIEEIH--WERGGR 558

Human   257 LLSGGISDH---NRRLTI-PNPTGSDAGYYECEAVLRSSSVPSVVRGAYLSVLEPPQFVKEPERH 317
            .|...|...   :..||| |....||:|.|.|.|  |:....|..|...::|:.||:........
  Fly   559 ELPDDIRQRVQPDGSLTISPVQKNSDSGVYTCWA--RNKQGHSARRSGEVTVIVPPKLSPFQTNI 621

Human   318 ITAEMEKVVDIPCQ-AKGVPPPSITWYKDAAVVEVEKLTRFRQ--RNDGGLQISGLVPDDTGMFQ 379
            :...|.....:.|. .||..|.:|.|.||...::..:....:|  :.:..|.|..|..|.||.:.
  Fly   622 LQLNMGDRASLTCSVVKGDLPLTINWRKDGRPIDPTQHMSVKQVDQYNSILVIENLGSDHTGNYS 686

Human   380 CFARNAAGEVQTSTYLAVTSIAPNITRGPLDSTVIDGMSVVLACETSGAPRPAITWQK--GERIL 442
            |..||:|.||:.|..|.| ::.|.....|:|:.|.....::|.|:..|.|.|:|.|:|  |.:  
  Fly   687 CVVRNSAAEVENSQALLV-NVPPRWIVEPVDANVERNRHIMLHCQAQGVPTPSIVWKKATGSK-- 748

Human   443 ASGSVQLPRFTP----LESGSLLISPTHISDAGTYTCLATNSRGVDEASA-DLVVWARTRITKPP 502
             ||..:..|..|    |.:||||:........|.|.|.|.|..|...... .|.|.:....:...
  Fly   749 -SGEYEEVRERPFTKLLGNGSLLLQHVKEDREGFYLCQANNGIGTGIGKVIQLKVNSSPYFSSTS 812

Human   503 QDQSVIKGTQASMVCGVTHDPRVTIRYIWEKDGA-TLGTESHPRIRLDR-------NGSLHISQT 559
            :...|.||..|.:.|.|:.|..:.|  :|.:.|. ||...::.:|.:.:       :..|.|...
  Fly   813 RSVMVKKGDTALLQCAVSGDKPINI--VWMRSGKNTLNPSTNYKISVKQEATPDGVSAELQIRTV 875

Human   560 WSGDIGTYTCRVISAGGNDSRSAHLRVRQLPHAPEHPVATLSTVERRAINLTWTKPFDGNSPLIR 624
            .:.|.|.|.||..:..|||.:...|:|::.|..|.  |...:.:..|::|:.|.....|...:.:
  Fly   876 DATDSGPYFCRASNLYGNDQQLVQLQVQEPPLPPS--VLEAAMISSRSVNIKWQPKTLGTGDVTK 938

Human   625 YILEMSE--NNAP-------WTVLLASVDPKATSVTVKGLVPARSYQFRLCAVNDVGKGQFSKDT 680
            ||:|..|  ::.|       |..:... ||...:..::.|.||..|.||:.|....|:   |..:
  Fly   939 YIVEFREADHSLPPALFVDQWQQIEVK-DPPHFNAMIENLKPATRYAFRVIAEGSAGR---SAPS 999

Human   681 ERVSLPEEP--PTAPPQNVIASGRTNQSIMIQWQPPPESHQNGILKGYIIRYCLAGL-PVGYQFK 742
            :.:.:..||  |..||.::.|...::..::|.|..|....::|.::||.:.|.|:.. ...|.|.
  Fly  1000 QELIVRTEPQRPAGPPLSLSARPLSSTELLISWVAPLPELRHGDIQGYNVGYKLSSSGNTAYNFT 1064

Human   743 NIT-DADVNN--LLLEDLIIWTNYEIEVAAYNSAGLGVYSSKVTEWTLQGVPTVPPGNVHAEATN 804
            ::: |.|..|  |||..|..:..|.:.|.|:|..|.|..|......|::.||:.||.:|...|.:
  Fly  1065 SVSGDGDGGNGELLLSGLAKFARYTVVVQAFNQVGPGPLSEPTAAQTMEDVPSRPPEDVRCAALS 1129

Human   805 STTIRFTWNAPSPQFINGINQGYKLIAWEP------EQEEEV--------TMVTARPNFQDSIHV 855
            |.:::.:|..|.....||:.|||||| :||      ..::||        |||            
  Fly  1130 SQSLQVSWQPPPIYHTNGLLQGYKLI-FEPIIDDIQPSKDEVESRKTTALTMV------------ 1181

Human   856 GFVSGLKKFTEYFTSVLCFTTPGDGPRSTPQLVRTHEDVPGPVGHLSFSEILDTSLKVSWQEPGE 920
              ::||:|:|.|...||..|..|||..|.|....:.||||.....:........||.:||..|.|
  Fly  1182 --LTGLRKYTNYSIQVLAHTRMGDGVVSKPLFCHSEEDVPEAPADIKVVSSSSQSLYISWLPPNE 1244

Human   921 KNGILTGYRI------SWEEYNRTNTRVTHYLPNVTLEYRVTGLTALTTYTIEVAAMTSKGQG-- 977
            .||::|.|.:      ..||.|...    ..||:....|...||.....|...|.|.|..|:|  
  Fly  1245 PNGVITKYSLYTRVVNGREELNNEK----RSLPSQQAYYEAKGLHPHMEYQFWVTASTRVGEGKS 1305

Human   978 -QVSASTISSGVPPELPGPPTNLGISNIGPRSVTLQFRPGYDGKTSISRWLVEAQVGVVGEGE-E 1040
             :||:...::.:|..:        ||..||     ..||.        |..|......||:.: |
  Fly  1306 SRVSSQITTNRIPARI--------ISFGGP-----VVRPW--------RSTVTLPCTAVGKPKRE 1349

Human  1041 WLL---------IH--QLSNEPD--ARSMEVPDLNPFTCYSFRMRQV-NIVGTSPPSQPSRKIQT 1091
            |..         :|  ||.:..|  ..|:::.|...::|      || |.:||      .|...|
  Fly  1350 WFKSDVALRQGGLHNSQLLDSGDLIISSLQLADGGNYSC------QVDNGIGT------DRLTHT 1402

Human  1092 L--QAPPDMAPANVSLRTASETSLWLRWMPLPEMEYNGNPESVGYKIKYSRSDGHGKTLSHVVQD 1154
            |  |.|| .||. :.:.:|:.:|:.:.|    :..:.||....||.:.|.|::|:   ...:...
  Fly  1403 LIVQVPP-TAPV-LYVTSATSSSILMHW----KCGFTGNAPITGYTLFYRRANGN---TDEMQLS 1458

Human  1155 RVERDYTIEDLEEWTEYRVQVQAFNAIGSGPWSQTVVGRTRESVPSSGPTNVSALATTSSSMLVR 1219
            |....:.::.|...:.|::.:.|.|.:|:.|.|..:..||:...|.. |.:.:.||..|:|:|||
  Fly  1459 RHASSHELKGLMCGSTYQIHLSAQNKVGTSPTSTILHVRTQGQSPGH-PASTALLAPNSTSLLVR 1522

Human  1220 WSEVPEADRNGLVLGYKVMYKEKDSDTQPRFWLVEGNS---SRSAQLTGLGKYVLYEVQVLAFTR 1281
            ....|:   ||..|.|.|:.....:|.....|::..|:   .|...:..|....||::::.|...
  Fly  1523 LHSWPD---NGCPLLYFVLQYRAVTDDPDAEWVLVSNALKPQRRIVINNLQPSTLYQLRMEAHNV 1584

Human  1282 IG-------------DGSPSHPPILERTLDDVPGPPMGILFPEVRTTSVRLIWQPPAAPNG---- 1329
            .|             ||.|..|.|:.|....    ...::|     .::.|:....||.:|    
  Fly  1585 AGISQAEFNFVTLTKDGDPPPPEIMHRGRSG----QTTVIF-----ANINLLIPTIAAVSGMFCT 1640

Human  1330 ---IILAYQITHRLNTTTANTATVEVLAPSARQYTATGLKPESVYLFRITAQTRKGWGEAAEALV 1391
               ||:.|:  |.|...          .|.|.|   :.::.||:        ..:...|||:   
  Fly  1641 IIMIIVCYR--HMLKNA----------PPLAEQ---SQIQKESL--------ENRANSEAAQ--- 1679

Human  1392 VTTEKRDRPQPPSRPMVQQEDVRARSVLLSWEPGSDGLSPVRYYTIQTREL-----------PSG 1445
                 |:|.......:..|.:.:....       |:.:||  |.|.|..|.           |:.
  Fly  1680 -----RERYYATIHKVSMQNNDKIPET-------SEDISP--YATFQLSEAGGNMSQPHHGGPAN 1730

Human  1446 RWALHSASVSHNASSFIVDRLKPFTSYKFRVKATNDIGDSEFSE-ESESLTTLQAAPDEAPTILS 1509
            . .|||......|.:.......|..|...|..:.....:||.|| :.:.||:.:..        |
  Fly  1731 T-LLHSFMYHERALAEGCSSPPPAASKNRRRHSRKTEPESEESESDQDQLTSSRTE--------S 1786

Human  1510 VTPHTTTSVLIRWQPPAEDKINGILLGFRIRYRELLYEGLRGFTLRGINNPGATWAELTSMYSMR 1574
            ...|             |.||.          ..::|.|.:          .:|.::|:.|...:
  Fly  1787 SNQH-------------EGKIK----------HSIIYHGAQ----------SSTSSDLSPMSEQK 1818

Human  1575 NLSRPSLTQYELDNLNKHRRYEIRMSVYNAVGEGPSSPPQEVFVGEAVP-----------TAAPR 1628
            :|.|...::|.      |::|:                    |.....|           |.:..
  Fly  1819 SLPRRGRSRYH------HQQYQ--------------------FSTNTTPRHHNSNKMNNNTTSNT 1857

Human  1629 NVVVHGATATQLDVTWEPPPLDSQNGDIQGYKIYFWEAQRGNLTERVKTLFLAENSVKLKNLTGY 1693
            |......|||         |..|.|.:    ||.   :.||...:.:.:.|.:::|::.     :
  Fly  1858 NTTATNTTAT---------PSTSSNSN----KIL---SPRGGNLKSISSTFKSQDSIQC-----H 1901

Human  1694 TAYMVSVAAFNAAGDGPRSTPTQGQ--TQQAAPSAPSSVKFSELTTTSVNVSWEAPQFPNGILEG 1756
            ...:|...:.        ||..|.|  .||...|:.::.:.|.....|.::..:.|......|..
  Fly  1902 IPTLVKSPSI--------STQQQKQFHKQQLQNSSTNNSQHSSSNPNSSSLKQQQPLLITPKLHQ 1958

Human  1757 YRLVYEPCSPVDGVSKIVTVDVKGNSPL 1784
            .....:....:||:         |||||
  Fly  1959 LEANGQELLGLDGI---------GNSPL 1977

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
SDK2NP_001138424.1 Ig 27..109 CDD:299845 21/88 (24%)
IG_like 40..109 CDD:214653 19/75 (25%)
I-set 120..203 CDD:254352 20/90 (22%)
Ig 132..210 CDD:299845 19/85 (22%)
IG_like 222..304 CDD:214653 25/85 (29%)
IGc2 233..286 CDD:197706 17/56 (30%)
I-set 308..397 CDD:254352 25/91 (27%)
Ig 326..394 CDD:143165 22/70 (31%)
I-set 402..492 CDD:254352 29/96 (30%)
Ig 416..492 CDD:299845 25/82 (30%)
Ig 502..586 CDD:299845 24/91 (26%)
IG_like 502..586 CDD:214653 24/91 (26%)
FN3 590..681 CDD:238020 24/99 (24%)
FN3 693..786 CDD:238020 27/96 (28%)
FN3 794..890 CDD:238020 35/109 (32%)
FN3 895..983 CDD:238020 27/96 (28%)
FN3 993..1087 CDD:238020 24/108 (22%)
FN3 1099..1194 CDD:238020 20/94 (21%)
FN3 1201..1290 CDD:238020 26/104 (25%)
FN3 1301..1394 CDD:238020 18/99 (18%)
FN3 1400..1484 CDD:238020 16/94 (17%)
FN3 1503..1616 CDD:238020 15/112 (13%)
FN3 1626..1719 CDD:238020 18/94 (19%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1707..1729 7/23 (30%)
FN3 1724..1805 CDD:238020 12/61 (20%)
FN3 1837..1916 CDD:238020
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 2039..2067
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 2098..2172
PDZ-binding. /evidence=ECO:0000250|UniProtKB:Q6V4S5 2166..2172
Dscam2NP_001261500.1 Ig 51..127 CDD:299845
Ig 138..>203 CDD:299845
I-set 238..327 CDD:254352
Ig 247..327 CDD:299845
I-set 332..418 CDD:254352 24/94 (26%)
IGc2 344..407 CDD:197706 16/65 (25%)
IG_like 432..517 CDD:214653 20/91 (22%)
IGc2 436..507 CDD:197706 19/77 (25%)
I-set 521..610 CDD:254352 29/94 (31%)
IGc2 533..597 CDD:197706 20/69 (29%)
Ig 630..699 CDD:143165 21/68 (31%)
IG_like 714..802 CDD:214653 28/90 (31%)
Ig 725..802 CDD:299845 25/79 (32%)
Ig 823..894 CDD:143165 18/72 (25%)
FN3 906..1006 CDD:238020 24/105 (23%)
FN3 1013..1111 CDD:238020 27/97 (28%)
FN3 1119..1209 CDD:238020 34/104 (33%)
FN3 1219..1313 CDD:238020 27/97 (28%)
Ig 1336..1402 CDD:143165 18/77 (23%)
FN3 1409..1498 CDD:238020 21/97 (22%)
FN3 1515..1588 CDD:238020 20/75 (27%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG3510
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.810

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