DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment SDK2 and CG13506

DIOPT Version :9

Sequence 1:	NP_001138424.1	Gene:	SDK2 / 54549	HGNCID:	19308	Length:	2172	Species:	Homo sapiens
Sequence 2:	NP_001286718.1	Gene:	CG13506 / 37556	FlyBaseID:	FBgn0034723	Length:	503	Species:	Drosophila melanogaster

Alignment Length:	520	Identity:	97/520 - (18%)
Similarity:	162/520 - (31%)	Gaps:	183/520 - (35%)

- Green bases have known domain annotations that are detailed below.

Human   232 EVTLEC------VANARPLIKLHIIWKKDGVLLSGG---ISDH-----NRRLTIPNPTGSDAGYY 282
            :|.|.|      ::||       ::|.|:.::::.|   ||..     |..:.:.|.:..|:..|
  Fly    86 DVILNCDARNFQLSNA-------VVWYKNRIIIANGQNPISQRVQCMLNNSILLRNVSPEDSDDY 143

Human   283 ECEAVLRSSSVPSVVRGAYLSVLEPPQFVKEPERHITAEMEKVVDIPCQAKGVPPPSITWYKDAA 347
            .||.:                    ||.|::   |....:...:.|.|..:.:...|.|
  Fly   144 YCEIL--------------------PQRVRQ---HTALRVGARLSILCDDRDITDRSQT------ 179

Human   348 VVEVEKLTRFRQRNDGGLQISGLVPDDTGMFQCFARNAAGEVQTSTYLAVTSIAPNITRGPLDST 412
                     |||.:...|:....:||:.
  Fly   180 ---------FRQGDHHKLECRTYLPDNA------------------------------------- 198

Human   413 VIDGMSVVLACETSGAPRPAITWQKGERILASGSVQLPRFTPLESGSLLISPTHISDAGTYTCLA 477
                               .|.|...:   .:|.   |.....::|.:::......:||.|.|||
  Fly   199 -------------------TIKWSFND---LNGQ---PSSVDNQNGVIILDNVDEKNAGDYQCLA 238

Human   478 TN-SRGVDEASADLVVWARTRITKPPQDQSVIKGTQASMVCGVTHDPRVTIRYIWEKDGATLGTE 541
            .: ||.....:..:.|.....::....:.:..||..|.:.|.....|.....:|  |||.||...
  Fly   239 DDGSRHPPHGTVHIDVQYSPIVSTHRHNVNTEKGATAELYCNYRAKPIGRSYFI--KDGKTLQLS 301

Human   542 S----HPRIRLDRN-GSLHISQTWSGDIGTYTCRVISAGGNDSRSAHLRVRQLPHAPEHPVATLS 601
            .    ...:..|.| .:|.:.:....|:|.|.|:|.:|.|::....|     :.:.||.|.....
  Fly   302 DKYSLKDSVHNDHNRTTLIVREVTDSDLGEYLCQVENAIGSNEVKVH-----VSYNPETPQFEDM 361

Human   602 TVERRAINLTWTKPFDGNSPLIRYILEMSENNAPWTVLLASVDPKATS----VTVKGLVPARS-- 660
            |||...:.|.|         |:|....:||         |.:|.:.|.    .||:.|...|.
  Fly   362 TVEGNKVTLHW---------LVRSHQLLSE---------AMLDYQLTGSYTWSTVQVLETHRHNN 408

Human   661 -----------------YQFRLCAVNDVGKGQFSKDTERVSLPE-------EPPTAPPQNVIASG 701
                             :..|:...|..|...||.| ....:||       |....||..::.:|
  Fly   409 TDNIWKITHQLELSRGVWHARVKTKNTKGWSHFSND-HVFEIPEDSEVDKDEEVELPPDEIVQAG 472

Human 702 701
Fly 473 472

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
SDK2	NP_001138424.1	Ig	27..109	CDD:299845
		IG_like	40..109	CDD:214653
		I-set	120..203	CDD:254352
		Ig	132..210	CDD:299845
		IG_like	222..304	CDD:214653	16/85 (19%)
		IGc2	233..286	CDD:197706	15/66 (23%)
		I-set	308..397	CDD:254352	14/88 (16%)
		Ig	326..394	CDD:143165	10/67 (15%)
		I-set	402..492	CDD:254352	13/90 (14%)
		Ig	416..492	CDD:299845	13/76 (17%)
		Ig	502..586	CDD:299845	22/88 (25%)
		IG_like	502..586	CDD:214653	22/88 (25%)
		FN3	590..681	CDD:238020	25/113 (22%)
		FN3	693..786	CDD:238020	3/9 (33%)
		FN3	794..890	CDD:238020
		FN3	895..983	CDD:238020
		FN3	993..1087	CDD:238020
		FN3	1099..1194	CDD:238020
		FN3	1201..1290	CDD:238020
		FN3	1301..1394	CDD:238020
		FN3	1400..1484	CDD:238020
		FN3	1503..1616	CDD:238020
		FN3	1626..1719	CDD:238020
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1707..1729
		FN3	1724..1805	CDD:238020
		FN3	1837..1916	CDD:238020
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	2039..2067
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	2098..2172
		PDZ-binding. /evidence=ECO:0000250\|UniProtKB:Q6V4S5	2166..2172
CG13506	NP_001286718.1	IG_like	79..146	CDD:214653	14/66 (21%)
		IGc2	83..146	CDD:197706	14/66 (21%)
		IG_like	176..254	CDD:214653	21/154 (14%)
		Ig	176..239	CDD:299845	18/139 (13%)
		I-set	258..349	CDD:254352	22/97 (23%)
		Ig	275..348	CDD:143165	19/74 (26%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3510
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900