DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment SDK2 and wrapper

DIOPT Version :9

Sequence 1:	NP_001138424.1	Gene:	SDK2 / 54549	HGNCID:	19308	Length:	2172	Species:	Homo sapiens
Sequence 2:	NP_477404.1	Gene:	wrapper / 37555	FlyBaseID:	FBgn0025878	Length:	500	Species:	Drosophila melanogaster

Alignment Length:	541	Identity:	126/541 - (23%)
Similarity:	180/541 - (33%)	Gaps:	181/541 - (33%)

- Green bases have known domain annotations that are detailed below.

Human   183 VQAVNDKNGDNKTSQ-----PITL-TVENVGGPADPIAPTIIIPPKNTSVVAGTSEVTLECVANA 241
            |||..|.|.|.:.||     |.|: |.||                         ..|.|.|..|.
  Fly    21 VQAELDFNNDLENSQKFKSIPTTVKTYEN-------------------------DTVQLPCTLNT 60

Human   242 RPLIKLHIIWKKDGVLLSGGISDH-------------NRRLTIPNPTGSDAGYYECEAVLRSSSV 293
             |.  .::.|.:|.|.|..  |.|             |..|.:.|...||.|.|.||   .:|..
  Fly    61 -PF--RYVRWHRDDVALVD--SRHPELPPPDRIMLWPNGSLQVANVQSSDTGDYYCE---MNSDS 117

Human   294 PSVVRGAYLSVLEPPQFVKEPERHITAEMEKVVDIPCQAKGVPPPSITWYKDAAVVEVEKLTRFR 358
            ..||:...:.|...||.:.||.......:..:.::.|:|:|||.|.|||..:..|::.:..|..|
  Fly   118 GHVVQQHAIEVQLAPQVLIEPSDLTEQRIGAIFEVVCEAQGVPQPVITWRLNGNVIQPQSNTGNR 182

Human   359 Q--------RNDGGLQISGLVPDDTGMFQCFARNAAGE-VQTSTYLAVTSIAPNIT-RGPLDSTV 413
            |        ||..||            .:|.|.|..|| ...:.||.|. .:|.:: ..|:..|.
  Fly   183 QSLILEIKSRNQAGL------------IECVASNGVGEPAVANVYLHVL-FSPEVSIPQPVVYTK 234

Human   414 IDGMSVVLACETSGAPRPAITWQKGERILASGSVQLPRFTPLESG------------SLLISPTH 466
            : |....|.|....||...:.|......:|.|:......:.|::.            .|::....
  Fly   235 L-GSRAHLECIVEAAPAATVKWFHHGLPVALGAHSTTHESELQTNRSVDHYVNAVRHMLVVKSVR 298

Human   467 ISDAGTYTCLATNSRGVDEASADLVVWARTRITKP-PQDQSVIKGTQASMVCGVTHDPRVTIRYI 530
            .:|.|.|.|.|:|...|...|.:|.       .:| |....:..|||:|    .:|      ..:
  Fly   299 NADMGQYECRASNQISVKSGSVELT-------GRPMPCLFKINPGTQSS----TSH------VLV 346

Human   531 WEKDGATLGTESHPRIRLDRNGSLHISQTWSGDIGTYTCRVISAGGNDSRSAHLRVRQLPHAPEH 595
            |:       |||          .|.|.:                       ..|:.||:|
  Fly   347 WQ-------TES----------LLPIME-----------------------FKLKFRQIP----- 366

Human   596 PVATLSTVERRAINLTWTK---PFDGNSPLIRYILEMSENNAPWTVLLASVDPKATSVTVKGLVP 657
                 |....|.:...||:   |....:.|| ||                     |:.|:.||.|
  Fly   367 -----SNNVTRQVRTNWTELTIPAQATNGLI-YI---------------------TTYTLHGLQP 404

Human   658 ARSYQFRLCAVNDVGKGQFSK 678
            |..|:..:.|.|..|....||
  Fly   405 ASLYEVSVLARNSFGWSDNSK 425

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
SDK2	NP_001138424.1	Ig	27..109	CDD:299845
		IG_like	40..109	CDD:214653
		I-set	120..203	CDD:254352	10/25 (40%)
		Ig	132..210	CDD:299845	13/32 (41%)
		IG_like	222..304	CDD:214653	23/94 (24%)
		IGc2	233..286	CDD:197706	19/65 (29%)
		I-set	308..397	CDD:254352	28/97 (29%)
		Ig	326..394	CDD:143165	22/76 (29%)
		I-set	402..492	CDD:254352	22/102 (22%)
		Ig	416..492	CDD:299845	19/87 (22%)
		Ig	502..586	CDD:299845	13/83 (16%)
		IG_like	502..586	CDD:214653	13/83 (16%)
		FN3	590..681	CDD:238020	22/92 (24%)
		FN3	693..786	CDD:238020
		FN3	794..890	CDD:238020
		FN3	895..983	CDD:238020
		FN3	993..1087	CDD:238020
		FN3	1099..1194	CDD:238020
		FN3	1201..1290	CDD:238020
		FN3	1301..1394	CDD:238020
		FN3	1400..1484	CDD:238020
		FN3	1503..1616	CDD:238020
		FN3	1626..1719	CDD:238020
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1707..1729
		FN3	1724..1805	CDD:238020
		FN3	1837..1916	CDD:238020
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	2039..2067
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	2098..2172
		PDZ-binding. /evidence=ECO:0000250\|UniProtKB:Q6V4S5	2166..2172
wrapper	NP_477404.1	Ig	41..124	CDD:299845	28/115 (24%)
		IG_like	41..118	CDD:214653	26/109 (24%)
		IG_like	145..218	CDD:214653	24/84 (29%)
		Ig	147..219	CDD:299845	24/83 (29%)
		I-set	224..323	CDD:254352	20/99 (20%)
		IGc2	236..314	CDD:197706	16/77 (21%)
		FN3	339..431	CDD:238020	33/169 (20%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3510
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900