DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment SDK2 and unc-5

DIOPT Version :9

Sequence 1:NP_001138424.1 Gene:SDK2 / 54549 HGNCID:19308 Length:2172 Species:Homo sapiens
Sequence 2:NP_001286450.1 Gene:unc-5 / 36703 FlyBaseID:FBgn0034013 Length:1072 Species:Drosophila melanogaster


Alignment Length:340 Identity:79/340 - (23%)
Similarity:115/340 - (33%) Gaps:67/340 - (19%)


- Green bases have known domain annotations that are detailed below.


Human   211 DPIAPTIIIPPKNTSVVAGTSEVTLECVANARPLIKLHIIWKKDGVLLSGGISDHNRRLTIPNPT 275
            |.|.|...:.|...|:|...|              ..|   |.:..||.....|.|.|   |...
  Fly    47 DAIDPLTAMAPFANSLVTEES--------------AQH---KNNAELLGNSSEDENVR---PQQG 91

Human   276 GSDAGYYECEAVLRSSSVPSVVRGAYLSVLEP----PQFVKEPER-----------HITAEMEKV 325
            .|.:|.....|...|..:........||..|.    |.|:.|||.           ...|.....
  Fly    92 SSSSGLGSSGAAGGSGILLEEFNSGKLSPGEASNTLPIFLIEPESVFVVKNRPAVLKCKASHSLQ 156

Human   326 VDIPCQAKGVPPPSI--TWYKDAAVVEVEKLTRFRQRNDGGLQISGLVPDDTGMFQCFARNAAGE 388
            |...|.....||||.  |.......|.:|::|....|:    .:.....|.....:|.|.::.|.
  Fly   157 VIFKCSGSSQPPPSTHETHVDPHTGVNMEEVTATIHRD----LVDEFFGDGPFKCECHAWSSRGV 217

Human   389 VQT-STYLAVTSIAPNITRGPLDSTVIDGMSVVLACETSGA-PRPAITWQKGERILASGSVQLPR 451
            |:: :..:.:..|..:..:.|....:..|....|.||..|. |.|.:||.|...::.:.|.  |.
  Fly   218 VKSQAATVHIAYIRKSFNQSPTSLRLELGSRAELRCEPPGGFPEPKLTWHKNNAVITADSE--PG 280

Human   452 FTPLESGSLLISPTHISDAGTYTCLATN--SRGVDEASADLVV--------WARTR----ITKPP 502
            .| :.:|:|:.....:.....|:|.|.|  .|.|.: ||.|:|        |:..|    ..||.
  Fly   281 IT-VSAGTLIFRQVALQHMANYSCSAENIAGRRVSD-SAVLIVYVNGGWSTWSPWRECKCAGKPS 343

Human   503 QDQSVIKGTQASMVC 517
            |      |.:.|..|
  Fly   344 Q------GRKRSRTC 352

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
SDK2NP_001138424.1 Ig 27..109 CDD:299845
IG_like 40..109 CDD:214653
I-set 120..203 CDD:254352
Ig 132..210 CDD:299845
IG_like 222..304 CDD:214653 16/81 (20%)
IGc2 233..286 CDD:197706 10/52 (19%)
I-set 308..397 CDD:254352 22/102 (22%)
Ig 326..394 CDD:143165 16/70 (23%)
I-set 402..492 CDD:254352 25/92 (27%)
Ig 416..492 CDD:299845 24/78 (31%)
Ig 502..586 CDD:299845 4/16 (25%)
IG_like 502..586 CDD:214653 4/16 (25%)
FN3 590..681 CDD:238020
FN3 693..786 CDD:238020
FN3 794..890 CDD:238020
FN3 895..983 CDD:238020
FN3 993..1087 CDD:238020
FN3 1099..1194 CDD:238020
FN3 1201..1290 CDD:238020
FN3 1301..1394 CDD:238020
FN3 1400..1484 CDD:238020
FN3 1503..1616 CDD:238020
FN3 1626..1719 CDD:238020
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1707..1729
FN3 1724..1805 CDD:238020
FN3 1837..1916 CDD:238020
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 2039..2067
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 2098..2172
PDZ-binding. /evidence=ECO:0000250|UniProtKB:Q6V4S5 2166..2172
unc-5NP_001286450.1 I-set 233..321 CDD:254352 25/91 (27%)
Ig 236..321 CDD:299845 25/88 (28%)
TSP1 327..379 CDD:214559 8/32 (25%)
TSP1 401..>422 CDD:214559
ZU5 655..749 CDD:295340
Death_UNC5-like 973..1064 CDD:260051
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.910

Return to query results.
Submit another query.