DRSC/TRiP Functional Genomics Resources

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Protein Alignment SDK2 and Lac

DIOPT Version :9

Sequence 1:NP_001138424.1 Gene:SDK2 / 54549 HGNCID:19308 Length:2172 Species:Homo sapiens
Sequence 2:NP_523713.2 Gene:Lac / 36363 FlyBaseID:FBgn0010238 Length:359 Species:Drosophila melanogaster


Alignment Length:325 Identity:86/325 - (26%)
Similarity:125/325 - (38%) Gaps:41/325 - (12%)


- Green bases have known domain annotations that are detailed below.


Human   215 PTI-IIPPKNTSVVAGTSEVTLEC-VANARPLIKLHIIWKKDGVLLSGGIS------------DH 265
            ||| .|..:....:.||  |..:| |..|:....|.:....|.|.||.|.:            |.
  Fly    29 PTISYITQEQIKDIGGT--VEFDCSVQYAKEYNVLFLKTDSDPVFLSTGSTLVIKDSRFSLRYDP 91

Human   266 NR---RLTIPNPTGSDAGYYECEAVLRSSSVPSVVRGAYLSVLEPPQFVKEPERHITAEMEKVVD 327
            |.   :|.|.:...:|||.|.|:.|:  |:|..|.....|||..||.......:.:.|.....|.
  Fly    92 NSSTYKLQIKDIQETDAGTYTCQVVI--STVHKVSAEVKLSVRRPPVISDNSTQSVVASEGSEVQ 154

Human   328 IPCQAKGVPPPSITWYKD-AAVVEVEKLTRFRQRNDGGLQISGLVPDDTGMFQCFARNAAGEVQT 391
            :.|.|.|.|.|:|||.:: .|::..:..|..    ...|:|..:..:|.|.:.|.|.|...:...
  Fly   155 MECYASGYPTPTITWRRENNAILPTDSATYV----GNTLRIKSVKKEDRGTYYCVADNGVSKGDR 215

Human   392 STYLAVTSIAPNIT--RGPLDSTVIDGMSVVLACETSGAPRPAITWQKGERILASGS-VQLPRFT 453
            .........||.||  |..|...:...|.  |.|.....|.|||.|.|.:..||:.. ..:..|.
  Fly   216 RNINVEVEFAPVITVPRPRLGQALQYDMD--LECHIEAYPPPAIVWTKDDIQLANNQHYSISHFA 278

Human   454 PLE---SGSLLISPTHISDAGTYTCLATNSRGVDEASADL---VVWARTRITKPPQDQSVIKGTQ 512
            ..:   ..:|.:........|.|.|.|||..|..||..:|   ::    .:..|...|:.|.|.:
  Fly   279 TADEYTDSTLRVITVEKRQYGDYVCKATNRFGEAEARVNLFETII----PVCPPACGQAYIAGAE 339

Human   513  512
              Fly   340  339

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
SDK2NP_001138424.1 Ig 27..109 CDD:299845
IG_like 40..109 CDD:214653
I-set 120..203 CDD:254352
Ig 132..210 CDD:299845
IG_like 222..304 CDD:214653 26/97 (27%)
IGc2 233..286 CDD:197706 19/68 (28%)
I-set 308..397 CDD:254352 20/89 (22%)
Ig 326..394 CDD:143165 18/68 (26%)
I-set 402..492 CDD:254352 28/98 (29%)
Ig 416..492 CDD:299845 23/82 (28%)
Ig 502..586 CDD:299845 3/11 (27%)
IG_like 502..586 CDD:214653 3/11 (27%)
FN3 590..681 CDD:238020
FN3 693..786 CDD:238020
FN3 794..890 CDD:238020
FN3 895..983 CDD:238020
FN3 993..1087 CDD:238020
FN3 1099..1194 CDD:238020
FN3 1201..1290 CDD:238020
FN3 1301..1394 CDD:238020
FN3 1400..1484 CDD:238020
FN3 1503..1616 CDD:238020
FN3 1626..1719 CDD:238020
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1707..1729
FN3 1724..1805 CDD:238020
FN3 1837..1916 CDD:238020
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 2039..2067
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 2098..2172
PDZ-binding. /evidence=ECO:0000250|UniProtKB:Q6V4S5 2166..2172
LacNP_523713.2 IG_like 36..131 CDD:214653 26/98 (27%)
FR1 37..50 CDD:409353 3/14 (21%)
Ig strand A' 37..42 CDD:409353 0/4 (0%)
Ig strand B 44..51 CDD:409353 3/8 (38%)
CDR1 51..59 CDD:409353 2/7 (29%)
Ig strand C 59..63 CDD:409353 1/3 (33%)
FR2 60..63 CDD:409353 1/2 (50%)
CDR2 67..81 CDD:409353 5/13 (38%)
Ig strand C' 68..72 CDD:409353 2/3 (67%)
Ig strand C' 79..81 CDD:409353 0/1 (0%)
FR3 84..115 CDD:409353 9/30 (30%)
Ig strand D 84..90 CDD:409353 0/5 (0%)
Ig strand E 94..102 CDD:409353 2/7 (29%)
Ig strand F 108..115 CDD:409353 4/6 (67%)
CDR3 116..124 CDD:409353 3/9 (33%)
FR4 124..130 CDD:409353 0/5 (0%)
Ig strand G 124..130 CDD:409353 0/5 (0%)
Ig_3 134..208 CDD:404760 20/77 (26%)
Ig strand B 153..157 CDD:409353 1/3 (33%)
Ig strand C 166..170 CDD:409353 2/3 (67%)
Ig strand E 187..191 CDD:409353 1/3 (33%)
Ig strand F 201..206 CDD:409353 1/4 (25%)
Ig strand G 215..218 CDD:409353 0/2 (0%)
Ig 227..318 CDD:416386 26/92 (28%)
Ig strand C 256..260 CDD:409353 2/3 (67%)
Ig strand E 286..290 CDD:409353 1/3 (33%)
Ig strand F 300..305 CDD:409353 2/4 (50%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG3510
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.810

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