DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment SDK2 and Lar

DIOPT Version :9

Sequence 1:NP_001138424.1 Gene:SDK2 / 54549 HGNCID:19308 Length:2172 Species:Homo sapiens
Sequence 2:NP_001260594.1 Gene:Lar / 35259 FlyBaseID:FBgn0000464 Length:2032 Species:Drosophila melanogaster


Alignment Length:2005 Identity:407/2005 - (20%)
Similarity:686/2005 - (34%) Gaps:651/2005 - (32%)


- Green bases have known domain annotations that are detailed below.


Human   294 PSVVRGAYLSVLEPPQFVKEPERHITAEMEKVVDIPCQAKGVPPPSITWYKDAAVVEVEKLTRFR 358
            |::|..|:     ||:.:::|:.. ...:..|....|.|:|.|||||.|.|:...|...:.....
  Fly    27 PTIVDAAH-----PPEIIRKPQNQ-GVRVGGVASFYCAARGDPPPSIVWRKNGKKVSGTQSRYTV 85

Human   359 QRNDGGLQISGLVP----DDTGMFQCFARNAAGEVQTSTYLAVTSIA--------------PNIT 405
            ....||:.|..:.|    .|...::|.|.|..|:       ||::.|              |.||
  Fly    86 LEQPGGISILRIEPVRAGRDDAPYECVAENGVGD-------AVSADATLTIYEGDKTPAGFPVIT 143

Human   406 RGPLDSTVIDGMSVVLACETSGAPRPAITWQKGERILASGSVQLPRFTPLESGSLLISPTHISDA 470
            :||....:..|.:|::.|:..|.|.|.|.|.|.:   ....:..||:: |:.|.|.|..:...|.
  Fly   144 QGPGTRVIEVGHTVLMTCKAIGNPTPNIYWIKNQ---TKVDMSNPRYS-LKDGFLQIENSREEDQ 204

Human   471 GTYTCLATNSRGVDEASA-DLVVWAR---TRITKPPQDQS-VIKGTQASMVCGVTHDPRVTIRYI 530
            |.|.|:|.||.|.:.:.| :|.|..|   ...::||:..| |:.|:..::.|.....|...::  
  Fly   205 GKYECVAENSMGTEHSKATNLYVKVRRVPPTFSRPPETISEVMLGSNLNLSCIAVGSPMPHVK-- 267

Human   531 WEKDGATLGTESHPRIRLDRNGSLHISQTWSGDIGTYTCRVISAGGNDSRSAHLRVRQLPHAPEH 595
            |.|....|..|:...|..:....::|.::     ..|||...|..|.....:.::|:.||.||..
  Fly   268 WMKGSEDLTPENEMPIGRNVLQLINIQES-----ANYTCIAASTLGQIDSVSVVKVQSLPTAPTD 327

Human   596 PVATLSTVERRAINLTWTKPFDGNSPLIRYILEMSENNAPWTVLLASVDPKATS-VTVKGLVPAR 659
              ..:|.|...::.|.|:  :.|...|..|:::....||  ....:.:....|. ..|:.|.|..
  Fly   328 --VQISEVTATSVRLEWS--YKGPEDLQYYVIQYKPKNA--NQAFSEISGIITMYYVVRALSPYT 386

Human   660 SYQFRLCAVNDVGKGQFSKDTERVSLPEEPPTAP------------------PQNVIASGRTNQS 706
            .|:|.:.|||::|:|              ||:||                  |:||.....::.:
  Fly   387 EYEFYVIAVNNIGRG--------------PPSAPATCTTGDFSFGGTKMESAPRNVQVRTLSSST 437

Human   707 IMIQWQPPPESHQNGILKGYIIRYCLAGLPVGYQFKNITDADVNNLLLEDLIIWTNYEIEVAAYN 771
            ::|.|:||  ...||.:.||.:.|                                         
  Fly   438 MVITWEPP--ETPNGQVTGYKVYY----------------------------------------- 459

Human   772 SAGLGVYSSKVTEWTLQGVPTVPPGNVHAEATNSTTIRFTWNAPSPQFINGINQGYKLIAWEPEQ 836
                                          .|||.....:||:                      
  Fly   460 ------------------------------TTNSNQPEASWNS---------------------- 472

Human   837 EEEVTMVTARPNFQDSIHVGFVSGLKKFTEYFTSVLCFTTPGDGPRSTPQLVRTHEDVPGPVGHL 901
                .||       |:..:..||.|.....|...|..:|:.|.||.|||..|:..:.||....:.
  Fly   473 ----QMV-------DNSELTTVSELTPHAIYTVRVQAYTSMGAGPMSTPVQVKAQQGVPSQPSNF 526

Human   902 SFSEILDTSLKVSWQEPGEKNGILTGYRISWEEYNRTNTRVTHYLPNVTLE-YRVTGLTALTTYT 965
            ..::|.:|::.:.|.:|...:..:..|.:.|   |.|.....|:......| |.:.||...|.|.
  Fly   527 RATDIGETAVTLQWTKPTHSSENIVHYELYW---NDTYANQAHHKRISNSEAYTLDGLYPDTLYY 588

Human   966 IEVAAMTSKGQGQVSASTISSGVPPELPGPPTNLGISNIGPRSVTLQFRPGYDGKTSISRWLVEA 1030
            |.:||.:.:|:|                                                     
  Fly   589 IWLAARSQRGEG----------------------------------------------------- 600

Human  1031 QVGVVGEGEEWLLIHQLSNEPDARSMEVPDLNPFTCYSFRMRQVNIVGTSPPSQPSRKIQTLQ-- 1093
                                                           .|:||.    .::|.|  
  Fly   601 -----------------------------------------------ATTPPI----PVRTKQYG 614

Human  1094 APPDMAPANVSLRTASETSLWLRWMPLPEMEYNGNPESVGYK---IKYSRSDGHGKTLSHVVQDR 1155
            ||    |.|::....|.|::.|.|:|.|....||  ..:.||   ::..|.|....|::..:...
  Fly   615 AP----PRNITAIATSSTTISLSWLPPPVERSNG--RIIYYKVFFVEVGREDDEATTMTLNMTSI 673

Human  1156 VERDYTIEDLEEWTEYRVQVQAFNAIGSGPWSQTVVGRTRESVPSSGPTNVSALATTSSSMLVRW 1220
            |     :::|:.||||::.|.|..::|.||.|..::.||:|.||.. |.:|.|....|:|:.|.|
  Fly   674 V-----LDELKRWTEYKIWVLAGTSVGDGPRSHPIILRTQEDVPGD-PQDVKATPLNSTSIHVSW 732

Human  1221 SEVPEADRNGLVLGYKVMYKEKDSDTQPRFWLVEGNSSRSAQLTGLGKYVLYEVQVLAFTRIGDG 1285
            ....|.||||::.||.:                     .:.:|...||..|.|            
  Fly   733 KPPLEKDRNGIIRGYHI---------------------HAQELRDEGKGFLNE------------ 764

Human  1286 SPSHPPILERTLDDVPGPPMGILFPEVRTTSVRLIWQPPAAPNGIILAYQITHRLNTTTANTATV 1350
                 |.....:|.:                                                  
  Fly   765 -----PFKFDVVDTL-------------------------------------------------- 774

Human  1351 EVLAPSARQYTATGLKPESVYLFRITAQTRKGWGEAAEALVVTTEKRDRPQP---PSRPMVQQED 1412
                    ::..|||:|::.|..::.|.||||.|:.:.|:||.|       |   |.||.|..:.
  Fly   775 --------EFNVTGLQPDTKYSIQVAALTRKGDGDRSAAIVVKT-------PGGVPVRPTVSLKI 824

Human  1413 VRAR---SVLLSWEPGSDGLSPVRYYTIQTRELPSGRWALHSASVSHNASS--------FIVDRL 1466
            :...   |:.|.||..:.....:|.|.:        ||.:...::.....|        |  |.|
  Fly   825 MEREPIVSIELEWERPAQTYGELRGYRL--------RWGVKDQALKEEMLSGPQMTKKRF--DNL 879

Human  1467 KPFTSYKFRVKATNDIGDSEFSEESESLTTLQAAPDEAPTILSVTPHTTTSVLIRWQPPAEDKIN 1531
            :....|:|||..:|.||..:  |..:...|.:..|...|:.:::...|...:.:.|.||..:..|
  Fly   880 ERGVEYEFRVAGSNHIGIGQ--ETVKIFQTPEGTPGGPPSNITIRFQTPDVLCVTWDPPTREHRN 942

Human  1532 GILLGFRIRYRELLYEGLRGFTLRGINNPGATWAELTSMYSMRNLSRPSLTQYELDNLNKHRRYE 1596
            ||:..:.:::.:.:..||.                     |.||:   :|.:....||.::..|.
  Fly   943 GIITRYDVQFHKKIDHGLG---------------------SERNM---TLRKAVFTNLEENTEYI 983

Human  1597 IRMSVYNAVGEGPSSPPQEVFVGEAVPTAAPRNVVVHGATATQLDVTWEPPPLDSQNGDIQGYKI 1661
            .|:..|...|.||.| .:.:...|.....||.::.....:....::.|||.   :..|.:.||||
  Fly   984 FRVRAYTKQGAGPFS-DKLIVETERDMGRAPMSLQAEATSEQTAEIWWEPV---TSRGKLLGYKI 1044

Human  1662 YF----------WEAQRGNLTERVKTLFLAENSVKLKNLTGYTAYMVSVAAFNAAGDGPRSTPTQ 1716
            ::          |:.:...|||          |..|.||..:..|.|::||....|.|..|   :
  Fly  1045 FYTMTAVEDLDDWQTKTVGLTE----------SADLVNLEKFAQYAVAIAARFKNGLGRLS---E 1096

Human  1717 GQTQQAAP-SAPSSVKFSELTTTSVNVSWEAPQFPNGILEGYRLVYEPCSPVDGVSKIVTVDVKG 1780
            ..|.:..| ..|.:::..:::|.|:.:||..|.....:  .|::.::...        |.||.:|
  Fly  1097 KVTVRIKPEDVPLNLRAHDVSTHSMTLSWSPPIRLTPV--NYKISFDAMK--------VFVDSQG 1151

Human  1781 NS--------PLWLK-------VKDLAEGVTYRFRIRA--KTFTYGPEIEANVTTGPGEGAPGPP 1828
            .|        .:.||       :.:|:...||...:.|  ..::|.|..:..|||  ...||.|.
  Fly  1152 FSQTQIVPKREIILKHYVKTHTINELSPFTTYNVNVSAIPSDYSYRPPTKITVTT--QMAAPQPM 1214

Human  1829 GVPII--VRYSSAIAIHWSSGDPGKGPITRYVIEARPSDEGLWDILIKDIPKEVSSYTFSMDILK 1891
            ..|..  |.....|.:.........|||:.|.:...|.|:.    .:..||.:     |..|.|.
  Fly  1215 VKPDFYGVVNGEEILVILPQASEEYGPISHYYLVVVPEDKS----NLHKIPDQ-----FLTDDLL 1270

Human  1892 PG--------------------VSYDFRVIAVNDYGFGT-------------------------- 1910
            ||                    :.:.|.:.:.:||...|                          
  Fly  1271 PGRNKPERPNAPYIAAKFPQRSIPFTFHLGSGDDYHNFTNRKLEREKRYRIFVRAVVDTPQKHLY 1335

Human  1911 -----------------------------PSSPSQSVPAQKANPFYEEWWFLVVIALVGLIFIL- 1945
                                         |:.|..||...|..|  |..|  ||:.|:...||: 
  Fly  1336 TSSPFSEFLSLDMREAPPGERPHRPDPNWPAEPEVSVNRNKDEP--EILW--VVLPLMVSTFIVS 1396

Human  1946 LLVFVLIIRGQSKKYAKKTDSGNSAKSGALGHSEMMSLD--ESSFPALELNNRRLSVKNSFCRKN 2008
            ..:.||.:..:.::..|..|.....:       .:|:.|  ....|:..::.|||:.:       
  Fly  1397 TALIVLCVVKRRRQPCKTPDQAAVTR-------PLMAADLGAGPTPSDPVDMRRLNFQ------- 1447

Human  2009 GLYTRSPPRPSPGSLHYSDEDVTKYNDLIPAESSSLTEKPSEISDSQGSDSEYEVDSNHQKAHSF 2073
                      :||.:.:....::::.:.|....|:..:|.|:..:|.....::..|:::.:.:..
  Fly  1448 ----------TPGMISHPPIPISEFANHIERLKSNDNQKFSQEYESIEPGQQFTWDNSNLEHNKS 1502

Human  2074 VNHYISDPTYYNSWRRQQKGISRAQAYSYTESD--SGEPDHTTVTNSTSTQQGSL 2126
            .|.| ::.|.|:..|.|...:.......|..::  .|...|    |:....||.|
  Fly  1503 KNRY-ANVTAYDHSRVQLPAVEGVVGSDYINANYCDGYRKH----NAYVATQGPL 1552

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
SDK2NP_001138424.1 Ig 27..109 CDD:299845
IG_like 40..109 CDD:214653
I-set 120..203 CDD:254352
Ig 132..210 CDD:299845
IG_like 222..304 CDD:214653 3/9 (33%)
IGc2 233..286 CDD:197706
I-set 308..397 CDD:254352 23/92 (25%)
Ig 326..394 CDD:143165 20/71 (28%)
I-set 402..492 CDD:254352 30/90 (33%)
Ig 416..492 CDD:299845 25/76 (33%)
Ig 502..586 CDD:299845 17/84 (20%)
IG_like 502..586 CDD:214653 17/84 (20%)
FN3 590..681 CDD:238020 23/91 (25%)
FN3 693..786 CDD:238020 13/110 (12%)
FN3 794..890 CDD:238020 21/95 (22%)
FN3 895..983 CDD:238020 21/88 (24%)
FN3 993..1087 CDD:238020 3/93 (3%)
FN3 1099..1194 CDD:238020 27/97 (28%)
FN3 1201..1290 CDD:238020 19/88 (22%)
FN3 1301..1394 CDD:238020 14/92 (15%)
FN3 1400..1484 CDD:238020 23/97 (24%)
FN3 1503..1616 CDD:238020 23/112 (21%)
FN3 1626..1719 CDD:238020 25/102 (25%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1707..1729 6/22 (27%)
FN3 1724..1805 CDD:238020 19/98 (19%)
FN3 1837..1916 CDD:238020 20/153 (13%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 2039..2067 5/27 (19%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 2098..2172 7/31 (23%)
PDZ-binding. /evidence=ECO:0000250|UniProtKB:Q6V4S5 2166..2172
LarNP_001260594.1 Ig 35..129 CDD:299845 27/101 (27%)
I-set 36..129 CDD:254352 26/100 (26%)
IG_like 146..227 CDD:214653 26/84 (31%)
Ig 159..228 CDD:299845 23/72 (32%)
I-set 234..318 CDD:254352 18/90 (20%)
Ig3_RPTP_IIa_LAR_like 249..317 CDD:143216 14/74 (19%)
fn3 324..404 CDD:278470 23/99 (23%)
FN3 423..514 CDD:238020 32/196 (16%)
FN3 520..610 CDD:238020 24/196 (12%)
FN3 616..707 CDD:238020 28/101 (28%)
FN3 712..810 CDD:238020 36/194 (19%)
FN3 832..907 CDD:238020 20/86 (23%)
FN3 914..1005 CDD:238020 23/115 (20%)
FN3 1012..1101 CDD:238020 26/104 (25%)
fn3 1106..1198 CDD:278470 19/101 (19%)
PTPc 1476..1731 CDD:214550 17/82 (21%)
PTPc 1503..1731 CDD:238006 13/55 (24%)
PTPc 1763..2022 CDD:214550
PTPc 1791..2022 CDD:238006
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.910

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