DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment SDK2 and Ptp36E

DIOPT Version :9

Sequence 1:	NP_001138424.1	Gene:	SDK2 / 54549	HGNCID:	19308	Length:	2172	Species:	Homo sapiens
Sequence 2:	NP_001286033.1	Gene:	Ptp36E / 35091	FlyBaseID:	FBgn0267486	Length:	682	Species:	Drosophila melanogaster

Alignment Length:	129	Identity:	31/129 - (24%)
Similarity:	44/129 - (34%)	Gaps:	53/129 - (41%)

- Green bases have known domain annotations that are detailed below.

Human    32 PVRTQVHLEGNRLVLTCMAEGSWPLEFK---------WLHNNRELTKFSLEY-RYMITSLD-RTH 85
            |.|| |.|    ..|||     ||:..|         :|.|..|:.:..::| ...:.|.| |:.
  Fly   566 PTRT-VQL----FQLTC-----WPMGHKVPSSTNSLVYLMNMVEIWRNKVDYGPVCVVSPDGRSR 620

Human    86 AGFY----RCIVRNRMGALLQRQTEVQVAYMGSFEEGEKHQSVSHGEAAVIRAPRIASFPQPQV 145
            ||.|    .||                            .|.:.|||..|.:|.:.....:||:
  Fly   621 AGVYCAANACI----------------------------EQVIQHGEVDVFQAVKTVRRHRPQL 656

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
SDK2	NP_001138424.1	Ig	27..109	CDD:299845	23/91 (25%)
		IG_like	40..109	CDD:214653	18/83 (22%)
		I-set	120..203	CDD:254352	8/26 (31%)
		Ig	132..210	CDD:299845	3/14 (21%)
		IG_like	222..304	CDD:214653
		IGc2	233..286	CDD:197706
		I-set	308..397	CDD:254352
		Ig	326..394	CDD:143165
		I-set	402..492	CDD:254352
		Ig	416..492	CDD:299845
		Ig	502..586	CDD:299845
		IG_like	502..586	CDD:214653
		FN3	590..681	CDD:238020
		FN3	693..786	CDD:238020
		FN3	794..890	CDD:238020
		FN3	895..983	CDD:238020
		FN3	993..1087	CDD:238020
		FN3	1099..1194	CDD:238020
		FN3	1201..1290	CDD:238020
		FN3	1301..1394	CDD:238020
		FN3	1400..1484	CDD:238020
		FN3	1503..1616	CDD:238020
		FN3	1626..1719	CDD:238020
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1707..1729
		FN3	1724..1805	CDD:238020
		FN3	1837..1916	CDD:238020
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	2039..2067
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	2098..2172
		PDZ-binding. /evidence=ECO:0000250\|UniProtKB:Q6V4S5	2166..2172
Ptp36E	NP_001286033.1	Y_phosphatase	125..368	CDD:395053
Ptp36E	NP_001286033.1	Y_phosphatase	428..671	CDD:395053	31/129 (24%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910