DRSC/TRiP Functional Genomics Resources

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Protein Alignment SDK2 and DIP-theta

DIOPT Version :9

Sequence 1:NP_001138424.1 Gene:SDK2 / 54549 HGNCID:19308 Length:2172 Species:Homo sapiens
Sequence 2:NP_723103.1 Gene:DIP-theta / 33795 FlyBaseID:FBgn0051646 Length:606 Species:Drosophila melanogaster


Alignment Length:511 Identity:100/511 - (19%)
Similarity:182/511 - (35%) Gaps:122/511 - (23%)


- Green bases have known domain annotations that are detailed below.


Human   216 TII--IPPKN---------TSVVAGTSEVTLECVANARPLIKL---------------HIIWKKD 254
            |::  ||.|:         ...|..:.|..|:||.:.....|:               |:|.|..
  Fly   119 TVVNAIPEKDLPKFGELLQNVTVPVSREAVLQCVVDNLQTYKIAWLRVDTQTILTIQNHVITKNH 183

Human   255 GVLLSGGISDHNRR---LTIPNPTGSDAGYYECEAVLRSSSVPSVVRGAYLSVLEPPQFVKEP-E 315
            .:    .|:...:|   |.|.:...||.|:|.|:  :.:..:.|.|  .||.|:.||..:..| .
  Fly   184 RM----SITHAEKRAWILRIRDVKESDKGWYMCQ--INTDPMKSQV--GYLDVVVPPDILDYPTS 240

Human   316 RHITAEMEKVVDIPCQAKGVPPPSITWYKDAA-VVEVEKLTRFRQRNDGGLQISGLVPDDTGMFQ 379
            ..:.......|.:.|.|.|.|.|:|||.::.. ::.:.........|...|.|:.:...:.|.:.
  Fly   241 TDMVIREGSNVTLKCAATGSPTPTITWRREGGELIPLPNGAEAVAYNGSFLTIAKVNRLNMGAYL 305

Human   380 CFARNAAGEVQTSTYLAVTSIAPNITRGPLDSTVIDG---MSVVLACETSGAPRPAITWQKGERI 441
            |.|.|......:...:.:....|.|.   :.:.::..   .::.|.|::...|:....|.|.:.|
  Fly   306 CIASNGIPPTVSKRVMLIVHFPPMIW---IQNQLVGAALTQNITLECQSEAYPKSINYWMKNDTI 367

Human   442 LASGSVQLPRFTP--LESG-----SLLISPTHISDAGTYTCLATNSRGVDEASADLVVWARTRIT 499
            :..|.    ||.|  .|||     .|.|....|.|.|.|.|:|.||.|..:.:        .::.
  Fly   368 IVPGE----RFVPETFESGYKITMRLTIYEVDIQDFGAYRCVAKNSLGDTDGA--------IKLY 420

Human   500 KPPQDQSVIKGTQASMVCGVTHDPRVTIRYIWE-KDGATLGTESHP------------RIRLDRN 551
            ..||..::   |..:....:...|.|.::|..| :.|::..:.::|            :::..::
  Fly   421 HIPQTTTM---TTMAPTVSINTVPVVLVKYNKEQRYGSSQNSNTNPYNFNPGNSQQNTKLQRGKS 482

Human   552 GSLHISQTWSG-------------------DIGTYTCRVISAGGNDSRSAHLRVRQLPHAPEHPV 597
            .|....|:.||                   ...:.:....|.|.:..:..|.:.:|..|..:|..
  Fly   483 NSKGSDQSPSGLNNVFVGATSSLWNSQDHHSSSSSSSSASSRGRDHHQQQHHQQQQQNHGSDHGA 547

Human   598 ATLSTVERRAINLTWTKPFDGNSP--------LIRYILEMSENNAPWTVLLASVDP 645
            :..|               ||.||        .:...|:..::...|...|:.:.|
  Fly   548 SYRS---------------DGKSPHLTNHDAKSLTDDLDRMQDLKGWASRLSPISP 588

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
SDK2NP_001138424.1 Ig 27..109 CDD:299845
IG_like 40..109 CDD:214653
I-set 120..203 CDD:254352
Ig 132..210 CDD:299845
IG_like 222..304 CDD:214653 23/108 (21%)
IGc2 233..286 CDD:197706 16/70 (23%)
I-set 308..397 CDD:254352 18/90 (20%)
Ig 326..394 CDD:143165 16/68 (24%)
I-set 402..492 CDD:254352 26/99 (26%)
Ig 416..492 CDD:299845 24/85 (28%)
Ig 502..586 CDD:299845 16/115 (14%)
IG_like 502..586 CDD:214653 16/115 (14%)
FN3 590..681 CDD:238020 11/64 (17%)
FN3 693..786 CDD:238020
FN3 794..890 CDD:238020
FN3 895..983 CDD:238020
FN3 993..1087 CDD:238020
FN3 1099..1194 CDD:238020
FN3 1201..1290 CDD:238020
FN3 1301..1394 CDD:238020
FN3 1400..1484 CDD:238020
FN3 1503..1616 CDD:238020
FN3 1626..1719 CDD:238020
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1707..1729
FN3 1724..1805 CDD:238020
FN3 1837..1916 CDD:238020
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 2039..2067
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 2098..2172
PDZ-binding. /evidence=ECO:0000250|UniProtKB:Q6V4S5 2166..2172
DIP-thetaNP_723103.1 Ig 137..230 CDD:299845 23/100 (23%)
IG_like 137..230 CDD:214653 23/100 (23%)
IG_like 240..324 CDD:214653 16/83 (19%)
IGc2 247..310 CDD:197706 15/62 (24%)
Ig 327..419 CDD:299845 26/106 (25%)
IG_like 343..420 CDD:214653 24/88 (27%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG3510
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.810

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